Hyoscyamine is an anticholinergic medication used to treat gastrointestinal disorders which include irritable bowel syndrome (IBS), peptic ulcers, and spasms in the stomach, intestines or bladder. Since hyoscyamine is available in a sublingual dosage form, it works quickly to alleviate symptoms. This medication reduces stomach acid production, slows the natural movements of the digestive tract by relaxing the muscles.

Lubiprostone (Amitiza®) is a medication used to treat chronic idiopathic constipation, irritable bowel syndrome with constipation (IBS-C), and opioid-induced constipation. It works by increasing the secretion of fluid in the intestines, which softens stools and promotes regular bowel movements. Amitiza helps relieve symptoms such as abdominal discomfort, bloating, and straining, improving overall digestive function.

Dicyclomine is an antispasmodic medication used for the treatment of abdominal pain and spasms caused by irritable bowel syndrome (IBS).

Promethazine is an antiemetic used to prevent and treat motion sickness. Promethazine is also used to prevent and control nausea and/or vomiting.  Promethazine is also a first-generation antihistamine, indicated for various allergic conditions, including seasonal allergies, allergic conjunctivitis, and uncomplicated skin manifestations of hives.