Desvenlafaxine is a medication that is FDA approved to treat major depressive disorder (MDD). This medication is also used off-label to treat vasomotor symptoms (eg hot flashes) for postmenopausal patients. Desvenlafaxine is a serotonin-norepinephrine reuptake inhibitor (SNRI), which works by increasing the levels of serotonin and norepinephrine in the brain and are associated with mood regulation. Desvenlafaxine is a synthetic form of the active metabolite of venlafaxine, another antidepressant. Because desvenlafaxine is already in its active form, it doesn’t need to be metabolized by the liver. This means its effects are more consistent and less likely to vary from person to person when compared to venlafaxine.

Vilazodone is used to treat low mood and depression. Vilazodone is a unique antidepressant because of its dual mechanism of action, primarily working as a selective serotonin reuptake inhibitor (SSRI) in addition to acting as a partial agonist at serotonin 1A (5-HT1A) receptors. Treatment of depression can require trial of different antidepressants one at a time to find the best fit. Noticeable improvements in mood may appear after 1 to 2 weeks of daily use with a recommended trial period of 6 to 8 weeks for full therapeutic effects.

Duloxetine is a selective serotonin-norepinephrine reuptake inhibitor (SNRI) used to treat anxiety, low mood (depression), fibromyalgia, long term pain problems or neurological pain associated with diabetes. Initial effects may be observed within 2 weeks of treatment, with continued improvements through 4 to 6 weeks.

Citalopram is a selective serotonin reuptake inhibitor (SSRI) used to treat low mood and depression. Treatment of depression can require trial of different SSRIs one at a time to find the best fit for you. Noticeable improvements in mood usually appear after 4 weeks of daily use with a recommended trial period of 4 to 12 weeks.

Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) used to treat low mood and depression. Treatment of depression can require trial of different SSRIs one at a time to find the best fit for you. Noticeable improvements in mood usually appear after 4 weeks of daily use with a recommended trial period of 4 to 12 weeks.

Trazodone is a selective serotonin reuptake inhibitor (SSRI) used to treat low mood and depression. Treatment of depression can require trial of different SSRIs one at a time to find the best fit for you. Noticeable improvements in mood usually appear after 4 weeks of daily use with a recommended trial period of 4 to 12 weeks.

Sertraline is a selective serotonin reuptake inhibitor (SSRI) used to treat low mood and depression. Treatment of depression can require trial of different SSRIs one at a time to find the best fit for you. Noticeable improvements in mood usually appear after 4 weeks of daily use with a recommended trial period of 4 to 12 weeks.

Escitalopram is a selective serotonin reuptake inhibitor (SSRI) used to treat low mood and depression. Treatment of depression can require trial of different SSRIs one at a time to find the best fit for you. Noticeable improvements in mood usually appear after 4 weeks of daily use with a recommended trial period of 4 to 12 weeks.

Venlafaxine is a serotonin and norepinephrine reuptake inhibitor (SNRI) used to treat depression. Treatment of depression can require trial of different SNRIs or SSRIs one at a time to find the best fit for you. Noticeable improvements in mood usually appear after 4 weeks of daily use with a recommended trial period of 4 to 12 weeks.

Paroxetine is a selective serotonin reuptake inhibitor (SSRI) used to treat low mood and depression. Treatment of depression can require trial of different SSRIs one at a time to find the best fit for you. Noticeable improvements in mood usually appear after 4 weeks of daily use with a recommended trial period of 4 to 12 weeks.

Bupropion is a dopamine and norepinephrine reuptake inhibitor used to treat low mood, depression, and seasonal depression.