Trazodone is a seretonin receptor antagnosist and reuptake inhibitor (SARI) used to treat low mood and depression. Treatment of depression can require trial of different medications, one at a time, to find the best fit for you. Noticeable improvements in mood usually appear after 4 weeks of daily use with a recommended trial period of 4 to 12 weeks.
- Used for the treatment of depression by restoring balance of serotonin in the brain
- Initially dosed at 50 mg twice daily and may increase based on response and tolerability
- Recommended to take after a meal or snack
- Lower dosing of 50 mg once daily may be initiated for individuals 65 years and older
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Trazodone Medication Description
Trazodone is a prescription antidepressant used to treat low mood and depression. It works by increasing the activity of serotonin, a neurotransmitter in the brain that helps regulate mood, sleep, and emotional balance. Restoring serotonin levels can help improve symptoms such as sadness, low energy, difficulty concentrating, and disrupted sleep patterns.
Although classified as a serotonin modulator rather than a traditional SSRI, trazodone is often considered when other antidepressants are not suitable or tolerated. Noticeable improvement in mood may take up to 4 weeks of consistent daily use, with a recommended trial period of 4 to 12 weeks before evaluating full effectiveness.
Usage Instructions
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Take exactly as prescribed by your healthcare provider
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Typically started at 50 mg twice daily, with dose adjustments based on response and tolerability
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May be initiated at 50 mg once daily in individuals 65 years and older
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Take after a meal or snack to reduce stomach upset
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Take at the same times each day to maintain steady levels in the body
Warnings & Precautions
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May cause drowsiness. Use caution when driving or operating machinery until you know how it affects you
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Possible side effects include dizziness, headache, dry mouth, blurred vision, or constipation
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Can increase the risk of suicidal thoughts, especially in young adults—monitor mood and behavior closely
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Do not stop taking suddenly without medical guidance, as withdrawal symptoms may occur
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Use with caution if you have heart rhythm problems, liver or kidney disease, or a history of seizures
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Avoid alcohol, as it may increase drowsiness and other side effects
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May interact with other medications, including certain migraine treatments, sedatives, and blood thinners
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Trazodone Side Effects
Side effects may include nausea, drowsiness, dry mouth, constipation, and loss of energy.
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Consumer Information Use and Disclaimer
This information should not be used to decide whether or not to take this medicine or any other medicine. Only a healthcare provider has the knowledge and training to decide which medicines are right for you. TelyRx does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a limited summary of general information about the medicine’s uses from the patient education materials and is not intended to be comprehensive. This limited summary does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not intended to provide medical advice, diagnosis or treatment and does not replace information you may receive from your healthcare provider. For a more detailed summary of information about the risks and benefits of using this medicine, please review the entire patient education information you receive with the medication.
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