Women's Health

Sulfamethoxazole / Trimethoprim DS

Generic For Bactrim DS

starting at $19.99

Sulfamethoxazole and trimethoprim is a combination antibiotic used for the treatment of urinary tract infections (UTIs).

Used to treat urinary tract infections in females

Taken twice daily for 3 days

Recommended to take with 8 ounces of water with or without food

Not suitable with a known allergy to sulfur containing medications, or women pregnant or planning to become pregnant

Must be used with caution in patients 65 years and older or those taking certain blood pressure medications

HSA/FSA Eligible

Sulfamethoxazole / Trimethoprim DS

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Sulfamethoxazole / Trimethoprim DS

Sulfamethoxazole and trimethoprim is a combination antibiotic used for the treatment of urinary tract infections (UTIs).

By clicking the “I Agree” button below, you certify under penalty of perjury that the following statements are true and correct and understand that a medical provider will rely on the truthfulness of your statements when determining whether a prescription is warranted and appropriate.

I agree that I:

am 18 years or older
have not had a hypersensitivity reaction to sulfamethoxazole, trimethoprim, other sulfur containing drugs, or any component of the formulation
do not have a history of drug induced thrombocytopenia from sulfamethoxazole or trimethoprim
do not have a history of anemia due to folate deficiency
am not taking dofetilide
Will use this medication as indicated for treatment of urinary tract infection for the intended duration of 3 days and understand that prolonged use should be avoided as it may result in a fungal or bacterial superinfection
understand that older adults (65 years and older) may be at greater risk for severe adverse reactions such as C. difficile infections, electrolyte disturbances, life-threatening hyperkalemia and neurotoxic effects such as psychosis and hallucination
do not have a history of severe liver (hepatic) or severe kidney (renal) impairment (CrCl <30 mL/min), and am not on dialysis
have an increased risk of high potassium levels if taking this medication with blood pressure medications in drug classes ACE inhibitors or ARBs. These medications include, but are not limited to, ACE inhibitors lisinopril, enalapril, benazepril, ramipril, and ARBs losartan, olmesartan, and irbesartan.
will use this medication for the treatment of a urinary tract infection and the recommended duration
do not have porphyria
do not have a seasonal allergies, asthma, or thyroid dysfunction
am not pregnant or breastfeeding, or planning to become pregnant
understand this is not a comprehensive list of precautions, risks, side effects, or details about taking this medication
understand that only major drug interactions are listed and have not been reviewed against the other medications, supplements, or herbal products I may be taking unless also filled by TelyRx

understand that TelyRx LLC does not provide medical care and the providers who use TelyRx to provide telehealth services (“Telehealth Providers”) should not replace your primary provider.
understand that the Telehealth Providers are not able to: (1) monitor ongoing health or lab values for side effects or efficacy, (2) observe how you (or your pet) tolerate any prescribed treatment, or (3) determine if the prescribed treatment is working as intended and assume any risks associated with this modality of care and waive any claim I may have in the future against TelyRx and/or the Telehealth Providers.
understand that by using this site, I have created a patient-client-doctor relationship and I am being directed by the Telehealth Providers to consult my primary provider soon after beginning any treatment prescribed by the Telehealth Providers.
understand that this is a supplemental mode of care for your convenience and the Telehealth Providers are not to be used, or relied on, as a replacement for in-person follow-up visits or interactions with your primary provider.

I agree that all statements above are true and my physician visit is complete.

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Sulfamethoxazole / Trimethoprim DS Medication Description
Sulfamethoxazole and trimethoprim tablets (Bactrim®, Septra®) are a prescription antibiotic combination commonly prescribed to treat a wide range of bacterial infections. These include urinary tract infections (UTIs), middle ear infections (otitis media), certain types of bronchitis, traveler’s diarrhea, and some intestinal infections. They are also used in specific cases to prevent or treat Pneumocystis jirovecii pneumonia (PJP), an opportunistic infection that can occur in patients with weakened immune systems.

This antibiotic works by combining two agents with different mechanisms: sulfamethoxazole inhibits the formation of folic acid in bacteria, while trimethoprim blocks a later step in the same pathway. Together, they prevent bacterial growth more effectively than either drug alone.

How to Use
- Typically prescribed as one double-strength (DS) tablet (800 mg sulfamethoxazole / 160 mg trimethoprim) taken every 12 hours, though dosing varies by infection type and severity.
- Tablets should be swallowed whole with a full glass of water.
- It is important to drink plenty of fluids during treatment to help prevent kidney stones or crystalluria.
- Take exactly as prescribed and complete the full course, even if symptoms improve earlier, to ensure the infection is fully treated.
- Dosing may be adjusted in patients with kidney problems or those on long-term preventive therapy.
Important Notes and Warnings
- Common side effects include nausea, vomiting, loss of appetite, and mild skin rash.
- Serious but less common risks include severe allergic reactions (including Stevens-Johnson syndrome), blood disorders, liver or kidney injury, and electrolyte imbalances (such as high potassium levels).
- Patients allergic to sulfa medications should not use this drug.
- Inform your healthcare provider if you are taking blood thinners (such as warfarin), ACE inhibitors, ARBs, diuretics, or other medications that can affect kidney function or potassium levels, as interactions are possible.
- This medication should not be used during late pregnancy, in breastfeeding infants under 2 months, or in patients with severe liver or kidney disease.
- Sun sensitivity can occur; protective clothing and sunscreen are recommended.
Sulfamethoxazole / Trimethoprim DS Side Effects

Side effects may include diarrhea, upset stomach, vomiting, and loss of appetite. Serious side effects may include C. diff infection, anemia and other blood disorders, high potassium levels, and hypersensitivity reactions.
Consumer Information Use and Disclaimer

This information should not be used to decide whether or not to take this medicine or any other medicine. Only a healthcare provider has the knowledge and training to decide which medicines are right for you. TelyRx does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a limited summary of general information about the medicine’s uses from the patient education materials and is not intended to be comprehensive. This limited summary does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not intended to provide medical advice, diagnosis or treatment and does not replace information you may receive from your healthcare provider. For a more detailed summary of information about the risks and benefits of using this medicine, please review the entire patient education information you receive with the medication.