Calcipotriene cream is a topical medication used to treat plaque psoriasis, a chronic skin condition that causes thick, scaly patches. It is a synthetic form of vitamin D3 that works by slowing the excessive growth of skin cells, which helps reduce scaling, redness, and plaque thickness. Calcipotriene is typically applied to affected areas once or twice daily, and improvement is usually seen within a few weeks. It is not intended for use on the face, groin, or underarms, as these areas are more sensitive to irritation.