Polymyxin B and Trimethoprim

Flu & Infections

Generic For Polytrim

starting at $34.99

Polymyxin B and Trimethoprim is an antibiotic eye drop used to treat mild to moderate eye infections including acute bacterial conjunctivitis (i.e. pink eye) and blepharoconjunctivitis (involving both the eyelids and the eyes).

Used to treat bacterial eye infections including bacterial conjunctivitis (pink eye) and blepharoconjunctivitis

Dosed as 1 drop in the affected eye(s) every 3 hours up to 6 doses per day for 7 to 10 days

Do not use contact lenses during treatment

HSA/FSA Eligible

H&P Certification

Tell us about yourself.

“You need to carefully review and make sure you can agree to each statement. If there are questions, a doctor will be in touch after checkout.”

Polymyxin B and Trimethoprim

By clicking the “I Agree” button below, you certify under penalty of perjury that the following statements are true and correct and understand that a medical provider will rely on the truthfulness of your statements when determining whether a prescription is warranted and appropriate.

I agree that I:

Am 18 years or older
Have not had a hypersensitivity reaction to trimethoprim, polymyxin B, or any component of its formulation
Have been diagnosed with acute bacterial conjunctivitis or blepharoconjunctivitis
Am not pregnant or breastfeeding
Understand this is for topical ophthalmic use only (i.e. only for use in the eyes)
Will use this medication for the appropriate duration of therapy of 7 to 10 days.
understand prolonged use may lead to a bacterial or fungal superinfection.
Will not wear contact lenses during the 7-10 day course of treatment with this medication
understand this is not a comprehensive list of precautions, risks, side effects, or details about taking this medication
understand that only major drug interactions are listed and have not been reviewed against the other medications, supplements, or herbal products I may be taking unless also filled by TelyRx
Understand I can find more information regarding drug-drug interactions at https://www.drugs.com/drug_interactions.html

understand that TelyRx LLC does not provide medical care and the providers who use TelyRx to provide telehealth services (“Telehealth Providers”) should not replace your primary provider.
understand that the Telehealth Providers are not able to: (1) monitor ongoing health or lab values for side effects or efficacy, (2) observe how you (or your pet) tolerate any prescribed treatment, or (3) determine if the prescribed treatment is working as intended and assume any risks associated with this modality of care and waive any claim I may have in the future against TelyRx and/or the Telehealth Providers.
understand that by using this site, I have created a patient-client-doctor relationship and I am being directed by the Telehealth Providers to consult my primary provider soon after beginning any treatment prescribed by the Telehealth Providers.
understand that this is a supplemental mode of care for your convenience and the Telehealth Providers are not to be used, or relied on, as a replacement for in-person follow-up visits or interactions with your primary provider.

I agree that all statements above are true and my physician visit is complete.

Cancel

Web-form is not active.

Skip to the end of the images gallery

For illustration purposes only. Product appearance may vary based on manufacturer availability.

Skip to the beginning of the images gallery

Polymyxin B and Trimethoprim Medication Description

Polymyxin B and trimethoprim eye drops (Polytrim®) are a prescription antibiotic combination commonly prescribed to treat bacterial eye infections such as conjunctivitis (“pink eye”) and blepharoconjunctivitis. Polymyxin B works by disrupting the outer cell membrane of certain bacteria, while trimethoprim blocks bacterial folic acid synthesis, preventing growth. Together, this dual mechanism provides broad-spectrum antibacterial coverage to help clear infection and relieve associated symptoms such as redness, discharge, and irritation.

How to Use

Typically prescribed as 1 drop in the affected eye(s) every 3 hours while awake, up to 6 times daily, for 7 to 10 days.

Wash hands before use and avoid touching the dropper tip to the eye or any surface to prevent contamination.

Tilt the head back, pull down the lower eyelid, and instill a drop into the conjunctival sac. Close the eye gently for 1 to 2 minutes to improve absorption.

Continue using the drops for the full duration prescribed, even if symptoms improve earlier, to ensure the infection is fully treated.

If multiple eye medications are prescribed, wait at least 5 minutes between administering each one.

Important Notes and Warnings

For ophthalmic use only; do not ingest.

Common side effects may include mild eye burning, stinging, redness, or temporary blurred vision.

Serious allergic reactions are rare but possible; discontinue and seek medical care if swelling, rash, or worsening irritation occurs.

This medication is not effective for viral or fungal eye infections. Using it inappropriately may contribute to antibiotic resistance.

Contact lenses should not be worn during treatment of an active infection; resume use only after the infection has cleared and with provider approval.

Inform your healthcare provider if you have a history of eye surgery, chronic eye conditions, or medication allergies before starting treatment.
Polymyxin B and Trimethoprim Side Effects

Polymyxin B and Trimethoprim side effects may include ocular stinging, burning, and itching.
Consumer Information Use and Disclaimer

This information should not be used to decide whether or not to take this medicine or any other medicine. Only a healthcare provider has the knowledge and training to decide which medicines are right for you. TelyRx does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a limited summary of general information about the medicine’s uses from the patient education materials and is not intended to be comprehensive. This limited summary does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not intended to provide medical advice, diagnosis or treatment and does not replace information you may receive from your healthcare provider. For a more detailed summary of information about the risks and benefits of using this medicine, please review the entire patient education information you receive with the medication.