The Wellness Collective

What to Know About Telmisartan

Reviewed by Ashley Robinson, PharmD, Pharmacy Manager for TelyRx

Telmisartan tablets via TelyRx

Table of Contents

Telmisartan is a prescription medication used to treat high blood pressure (hypertension). It’s also used to reduce the risk of heart attack, stroke, or death in patients 55 years of age or older who have a history of heart problems and are unable to take ACE inhibitors.

Telmisartan belongs to a class of drugs known as angiotensin II receptor blockers (ARBs). It is taken by mouth once daily. Common side effects include back or leg pain, stuffy nose, diarrhea, and skin ulcers.

How Does Telmisartan Work?

Telmisartan is an angiotensin II receptor blocker (ARB). It works by blocking the receptors in the body that normally bind to a substance called angiotensin II.

Angiotensin II is a hormone that causes the blood vessels to narrow or constrict. When this hormone binds to its receptors, blood pressure rises, forcing the heart to work harder to pump blood throughout the body.

By blocking these receptors, telmisartan prevents angiotensin II from constricting the vessels. This allows the blood vessels to relax and widen, facilitating smoother blood flow, lowering blood pressure, and making it easier for the heart to pump.

Drug Facts

Common Brands Micardis
Drug Class Angiotensin II receptor blocker (ARB)
Generic Status Generic for Micardis
Availability Prescription only

Dosing

Note: Dosing information below is educational only. Your prescribing physician will determine your specific dose based on your individual health needs. 

Telmisartan is an oral tablet available in dosage strengths of 20 mg, 40 mg, and 80 mg. It is typically taken by mouth once daily. The recommended dose depends on what you’re taking telmisartan for.

  • High blood pressure: The recommended starting dose is 40 mg once daily. Depending on how your blood pressure responds, your healthcare provider may adjust the dosage up or down, within the range of 20 mg to 80 mg once daily.
  • Cardiovascular risk reduction: The recommended dose is 80 mg taken once daily, but is often titrated up to this dose for tolerability.

Always follow your healthcare provider’s instructions for exact dosing.

FDA-Approved Uses

Telmisartan is FDA-approved for:

  • High blood pressure (hypertension)
  • Cardiovascular risk reduction in adults 55 years of age and older who are unable to take ACE inhibitors and have a history of coronary artery disease, stroke, peripheral arterial disease, or high-risk diabetes

Common Off-Label Uses

You may see telmisartan prescribed for uses that are not “FDA-approved.” This is a very common and legal practice called “off-label” prescribing, where a doctor uses their clinical judgment to prescribe a drug for a different (but well-researched) purpose.

Telmisartan may be prescribed off-label to slow the worsening of kidney problems in people with type 2 diabetes and high blood pressure.

Side Effects

Like all medications, telmisartan can cause side effects. Some common side effects may improve over time as your body adjusts to the medication. Other side effects may be serious and require medical attention.

Common Side Effects

  • Back pain
  • Upper respiratory tract infections, including cough and sore throat
  • Nasal congestion or stuffy nose
  • Diarrhea
  • Headache
  • Skin ulcer
  • Pain in the legs
  • Dizziness
  • Fatigue

Serious Side Effects

Serious side effects are rare, but it’s important to know what to look for if they do occur. Stop using telmisartan and call your doctor immediately if you experience: 

  • Severe allergic reactions: Symptoms include swelling of the face, lips, tongue, or throat; difficulty breathing or swallowing; severe rash or itching; fever.
  • Low blood pressure (hypotension): Significant drops in blood pressure may cause dizziness, lightheadedness, fainting, or confusion, especially in people who are dehydrated or taking diuretics (water pills).
  • Kidney damage: Symptoms include a reduced need to urinate, weakness, confusion, nausea, seizures, and swelling in the feet, ankles, or legs.
  • High potassium levels (hyperkalemia): This condition can be life-threatening. Symptoms include muscle weakness, slow or irregular heartbeats, nausea, vomiting, and difficulty breathing.

Call your doctor immediately if you experience any concerning or prolonged symptoms.

Pharmacist Tips

  • Take it consistently. It’s recommended to take telmisartan at the same time each day. It can be taken with or without food.
  • Monitor blood pressure at home. To track the medication’s effectiveness, check your blood pressure regularly at home and bring these logs to your appointments.
  • Rise slowly. Telmisartan can cause dizziness, especially during the first few days of treatment or when changing positions. It is recommended to get up slowly from sitting or lying down to avoid fainting.
  • Stay hydrated. Dehydration can increase the risk of low blood pressure and kidney damage. Drink plenty of water, especially on hot days or after exercise.
  • Store at room temperature. Telmisartan should be stored at room temperature between 68°F to 77°C (20°C to 25°C) in a cool, dry place. Do not remove the tablets from their blister packs until you are ready to take your dose.
  • Know the missed dose protocol. If a dose is missed, take it as soon as you remember, unless it’s almost time for your next dose. In that case, skip the missed dose and take your next dose as usual. Do not double up on doses of telmisartan.
  • Pregnancy warning: Telmisartan can cause serious harm or death to an unborn baby. If you are pregnant or plan to become pregnant, stop taking telmisartan and contact your provider.

Drug Interactions

Telmisartan can interact with other medications, potentially altering their effectiveness or increasing the risk of side effects. For example:

  • Aliskiren: This high blood pressure medication can interact with telmisartan and should not be taken at the same time.
  • Other blood pressure medications: Combining telmisartan with ACE inhibitors (like lisinopril or ramipril) or other ARBs is generally not recommended due to increased risks of kidney problems and hypotension.
  • NSAIDs: Nonsteroidal anti-inflammatory drugs like aspirin, ibuprofen (Advil) and naproxen (Aleve) can interact with telmisartan and may affect kidney function.
  • Lithium: Telmisartan can affect how your body processes lithium, a medication used for depression.
  • Digoxin: This heart medication may require dose adjustments or monitoring when taken with telmisartan.
  • Potassium supplements: Because telmisartan can raise potassium levels, it’s recommended to avoid taking potassium supplements or salt substitutes containing potassium.
  • Diuretics: Taking “water pills” can increase the risk of low blood pressure and kidney issues when taken with telmisartan.

Always give your doctor and pharmacist a complete list of all your medications, vitamins, and supplements to check for potential interactions.

FAQs

Why is telmisartan considered better than losartan for 24-hour blood pressure control? 

Both losartan and telmisartan are ARBs, but telmisartan’s longer half-life can provide more consistent blood pressure management over a 24-hour period.

Is it better to take telmisartan in the morning or at night? 

You should take telmisartan as directed by your doctor. Some providers may suggest a specific time based on when your blood pressure is highest, while others may simply recommend taking it at the same time every day to establish a routine.

Does telmisartan cause erectile dysfunction? 

Reports of erectile dysfunction (ED) are very rare among people taking telmisartan. Talk to your healthcare provider if you experience ED while taking telmisartan. 

Can I drink alcohol while taking telmisartan? 

It is unknown if alcohol interacts with telmisartan itself, but drinking alcohol may increase the risk of dizziness and low blood pressure — both possible side effects of telmisartan.

Does telmisartan cause hair loss? 

Telmisartan is not known to cause hair loss. If you experience hair loss while taking telmisartan, it is recommended to consult your healthcare provider to investigate other potential causes.

Does telmisartan interact with ibuprofen or other NSAIDs? 

Yes. NSAIDs, such as ibuprofen, aspirin, and naproxen, can interact with telmisartan. Taking them together may reduce the blood pressure-lowering effect or increase the risk of kidney problems.

How long does it take for telmisartan to start working? 

The medication can begin to lower blood pressure approximately 3 hours after a dose. However, it often takes up to 2 weeks to see a noticeable drop, and up to 4 weeks (one month) to experience maximum benefits.

Why does telmisartan sometimes come in a blister pack instead of a bottle? 

Telmisartan tablets are sensitive to environmental factors. It’s recommended not to remove the tablets from the blister packs until you are ready to take them, which helps protect the medication from moisture.

What happens if I miss a dose of telmisartan? 

If you miss a dose of telmisartan, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and continue with your regular schedule. Do not double up or take extra doses to make up for the missed one.

Can telmisartan cause anxiety or insomnia? 

Anxiety and insomnia are not listed as common side effects of telmisartan. However, nervousness can be a less common side effect. If you experience mood changes, consult your provider.

Is telmisartan a beta-blocker or a diuretic? 

Telmisartan is neither a beta-blocker nor a diuretic. It is an angiotensin II receptor blocker (ARB). While beta-blockers slow the heart rate and diuretics help remove fluid, ARBs work by relaxing blood vessels.

What is the difference between Telmisartan and Losartan? 

Both telmisartan and losartan are ARBs used for high blood pressure. However, telmisartan is additionally approved for reducing cardiovascular risk in patients aged 55+ with heart problems, while losartan is also approved to lower stroke risk in patients with a thickened heart (left ventricular hypertrophy) and to protect kidneys in people with type 2 diabetes.

Compare Medications

Compared: Telmisartan, Losartan (Cozaar), Olmesartan (Benicar), Irbesartan (Avapro), Lisinopril (Zestril, Prinivil), or Telmisartan-Amlodipine (Twynsta)?

There are several medications that your doctor can prescribe in place of telmisartan. Here are a few possible alternatives below.

  • Losartan (Cozaar): Another angiotensin II receptor blocker (ARB) used to treat high blood pressure, as well as to reduce stroke risk in people with a thickened heart (left ventricular hypertrophy), and to slow the worsening of kidney problems specifically in people with type 2 diabetes.
  • Olmesartan (Benicar): Another angiotensin II receptor blocker (ARB) used to treat high blood pressure.
  • Irbesartan (Avapro): Another angiotensin II receptor blocker (ARB) used to treat high blood pressure, including high blood pressure associated with diabetes-related kidney problems (diabetic nephropathy).
  • Lisinopril (Zestril, Prinivil): An angiotensin-converting enzyme (ACE) inhibitor used to treat high blood pressure and heart failure.
  • Telmisartan-amlodipine (Twynsta): A combination medication for high blood pressure that includes both telmisartan (an ARB) and amlodipine (a calcium channel blocker) in one tablet.
Disclaimer

Important: Information on this page is for educational purposes only. Prescribing decisions are made by independent, licensed providers. TelyRx operates technology-enabled pharmacies and a telehealth platform that connects patients with board-certified licensed providers. Prescriptions, when provider-approved and issued, are filled and shipped by TelyRx-affiliated pharmacies. We do not employ physicians or make prescribing decisions.

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