The Wellness Collective

How Travel, Stress, and Holidays Wreck Your Gut (and What to Do About It)

Reviewed by Adam Gardner, Licensed Pharmacist & COO of TelyRx

Common Thanksgiving foods can be a source of flare ups for many stomach issues.

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Traveling should feel like a break. Holidays are supposed to be full of joy. But if you’re dealing with bloating, nausea, or a sudden Irritable Bowel Syndrome (IBS) flare up the minute your schedule changes, you’re not alone. Many people experience holiday stomach problems, especially when they’re on the road, navigating stress, or indulging in festive foods.

A 2025 survey shows that 42% of travelers have underlying gut health issues that can be exacerbated by travel, and 27% experience an upset digestive system when traveling.

Your digestive system is more sensitive than you may think. Between the changes in routine, unfamiliar foods, emotional pressure, and traveling itself, your gut ends up taking a beating, often without warning. And if you already live with conditions like IBS, acid reflux, or motion sickness, this time of year can feel like a minefield.

Here’s the truth: stress and digestion are deeply connected, and holiday gut issues are common. But they’re also preventable. Whether you’re managing nausea while traveling or looking to prevent stomach issues during the holidays, understanding what’s going on in your body is the first step.

why travel wreaks havoc on digestion

Travel puts your body under a very specific kind of stress—one that’s not always obvious until your gut starts reacting. Your brain, sleep cycles, nervous system, and even digestion are all part of a delicate internal rhythm. Travel breaks that rhythm in several critical ways.

Jet lag and circadian disruption impact your energy levels and throw off your internal digestive schedule. Your body is used to releasing digestive enzymes at certain times of day, linked to your local light-dark cycle. When you shift time zones or eat at odd hours, your body gets confused.

This leads to irregular bowel movements, constipation, or bloating. Travelers commonly experience “first day constipation” or morning nausea when they land in a new time zone because their digestive hormones are out of sync.

Unfamiliar foods, even in small quantities, can radically shift your gut behavior. Your microbiome adapts to your normal diet over time. When you suddenly introduce new ingredients, unfamiliar bacteria, or indulgent desserts your body isn’t used to ingesting, your microbiome can’t keep up. The result? Bloating, cramping, changes in stool consistency, and even temporary inflammation. For those with IBS, this can be a major trigger.

Dehydration is often associated with traveling. Planes, in particular, reduce hydration rapidly due to low humidity. But travel in general limits when and how often you drink water—either because you’re avoiding airplane bathrooms, too busy at airports, or consuming dehydrating beverages like coffee, soda, or alcohol. Dehydration thickens stool, slows digestion, and increases nausea and bloating, especially in those already prone to digestive issues like IBS or acid reflux.

Limited access to bathrooms creates anxiety, especially in those with digestive conditions. Whether you’re stuck in a car for hours or trying to navigate a foreign city, the fear of not finding a restroom when needed triggers a sympathetic nervous system response. This tension can shut down digestion, make it harder to have a bowel movement, or cause an urgency episode that worsens symptoms.

Sleep disruption from jet lag or unfamiliar sleeping environments also affects digestion. Sleep and digestion are linked by melatonin and cortisol rhythms. Poor or irregular sleep can increase inflammation and gut permeability, making your system more reactive.

In short, travel creates a perfect storm: dehydration, stress, unfamiliar foods, and disrupted rhythms. Together, they throw off your gut’s natural balance and can lead to persistent holiday stomach problems.

how stress impacts your gut

A man sits in an airport, stressed from his travels.

Stress affects digestion through multiple biological pathways. It’s not just related to the feeling of being tense, but how that tension reshapes the way your entire gastrointestinal system functions.

When you experience stress, your sympathetic nervous system kicks in. This is the “fight or flight” response, which prioritizes short-term survival over non-essential functions like digestion. Blood flow to your gut decreases. Enzymatic activity slows down. Peristalsis (the wave-like muscle contractions that move food) becomes irregular.

This leads to either sluggish digestion (constipation, bloating, fullness) or accelerated digestion (diarrhea, urgency, stomach cramps). The direction often depends on how your individual body responds, but both outcomes are rooted in the same nervous system mechanism.

Meanwhile, your brain is also communicating directly with your gut through the gut-brain axis, a bidirectional highway of nerves and hormones. When stress hormones like cortisol and adrenaline spike, they cause your gut to react more powerfully to the same stimuli. A minor twinge becomes pain. A little gas turns into uncomfortable bloating.

Long-term stress impacts your gut microbiome, too. Studies show that chronic anxiety or unresolved emotional stress reduces microbial diversity, lowers levels of beneficial bacteria, and increases leaky gut.

During the holidays, stress is rarely one-dimensional. You’re dealing with travel delays, family dynamics, social events, end-of-year deadlines, financial strain, and sleep disruption—all of which overload your system.

According to the NIH, 60% of people with IBS say stress is their top trigger. For those living with IBS, GERD, chronic nausea, or functional GI disorders, stress is a full-body experience, and your gut is often the first place to feel it.

holiday triggers that upset your stomach

Even if you’re staying home, holiday habits tend to invite digestive chaos. Meals become more indulgent, schedules fall apart, and people ignore their bodies in favor of celebration.

Let’s break down some of the most common digestive saboteurs:

  • Rich, fatty foods take longer to digest and increase the risk of acid reflux. Your stomach has to produce more acid to break them down, and the food stays in your system longer. This can leave you feeling heavy, nauseous, or uncomfortably full for hours.
  • Alcohol irritates the stomach lining and weakens the muscular valve between your stomach and esophagus, known as the lower esophageal sphincter (LES). This allows acid to rise up and trigger heartburn. It also speeds up digestion in some people, leading to diarrhea.
  • Caffeine, particularly from coffee, tea, or chocolate desserts, increases stomach acid and stimulates bowel contractions. This can cause jitteriness, cramps, and loose stools, especially when paired with sugar or dairy.
  • Irregular eating patterns mess with your gut’s rhythm. If you skip meals all day and then gorge at dinner, your digestive system is caught off guard. Your pancreas has to pump out insulin rapidly, and your intestines have to process a massive volume of food at once.
  • Late-night eating is especially problematic. Lying down shortly after a heavy meal increases the risk of reflux because gravity no longer keeps food down in the stomach.
  • Overeating, even when it’s “just one more cookie,” causes the stomach to stretch and release more acid, which increases bloating and discomfort.

These behaviors happen more frequently around the holidays. Most people combine several of these triggers across days or weeks, which creates the perfect setup for holiday IBS flare ups, reflux, or unpredictable digestion.

how to protect your gut during travel & the holidays

A woman takes medication for her gut on a flight.

Preventing holiday stomach problems is all about preparation.

  • Hydrate early and often. Keep a reusable bottle with electrolytes or minerals.
  • Assemble a gut kit. Include anti-nausea meds, fiber packets, probiotics, peppermint oil capsules, and antacids.
  • Move after meals. A 10-minute walk improves glucose regulation and speeds digestion.
  • Sleep strategically. Protect your circadian rhythm by going to bed and waking up at roughly the same time daily.
  • Practice nervous system regulation. Try guided meditations, deep breathing, or EFT tapping during moments of overwhelm.

For IBS

  • Anchor your meals: Even if you’re eating new foods, try to eat at the same times daily.
  • BYO Snacks: Bring IBS-safe snacks like oatmeal cups, bananas, white rice crackers, or roasted carrots.
  • Hydration is medicine: Start your morning with warm water, and sip throughout the day to keep bowels moving.

The key is consistency. The more signals of stability you give your gut, the less likely it is to spiral. If you’re experiencing chronic IBS, prescription medications like Lubiprostone, Mesalamine, Dicyclomine, and Hyoscyamine can help.

Nausea and Motion Sickness

Motion sickness is caused by sensory mismatch: your eyes perceive stillness (like reading a book), while your body senses motion. You can combat this by:

  • Avoiding heavy meals within 2 hours of travel. Stick to light foods.
  • Keeping ginger and peppermint handy. Both have been shown to provide anti-nausea effects.
  • Sitting over the wings of a plane or in the front seat of a car to minimize motion perception.
  • Applying pressure to the P6 point on your wrist for relief.

If you’re highly sensitive, prescription anti-nausea medications like promethazine, scopolamine patches, or ondansetron can be considered for an extra layer of protection.

Acid Reflux and Heartburn

If you struggle with acid reflux and heartburn, often referred to as GERD, holidays can feel like a nonstop game of acid roulette.

  • Eat smaller meals more often instead of large feasts.
  • Avoid reclining or sleeping within 2–3 hours of your last meal.
  • Limit acidic and spicy foods, especially when on the go.

If you’re planning ahead, consider prescription acid reflux medications like pantoprazole or famotidine when triggers are unavoidable.

when to see a doctor

A woman sits by the toilet feeling nauseated.

Even if you manage things well, some symptoms need a professional’s eye. It’s recommended to reach out to a provider if:

  • You have persistent diarrhea, vomiting, or heartburn lasting more than 7–10 days.
  • You experience sharp or severe abdominal pain.
  • You notice blood in your stool or vomit.
  • You have frequent digestive episodes that interfere with work, sleep, or quality of life.

It’s better to rule out serious issues than to guess, especially when gut health is linked with so many parts of our body.

don’t let gut issues ruin your holidays

Your gut shouldn’t be the reason you skip out on life.

The holidays will always be chaotic, but with a better understanding of how stress, travel, and seasonal habits affect digestion, you can avoid preventable stomach issues and enjoy your plans.

TelyRx offers fast, discreet access to prescription meds that can help manage IBS, acid reflux, and nausea, delivered almost anywhere you are. Whether you’re home or hopping airports, feeling good in your body should always be part of the itinerary.

Disclaimer

This blog post is for informational purposes only and does not constitute medical advice, diagnosis, or treatment. The content provided here is not a substitute for professional medical advice, consultation, or care from a qualified healthcare provider. Always seek the guidance of your physician or another licensed health professional with any questions you may have regarding a medical condition or treatment. Do not disregard or delay seeking professional medical advice based on information read on this site. Learn more about our editorial standards here.

Don’t let your gut stop your plans.