The Wellness Collective

Managing Anxiety Without SSRIs: What No One Tells You

Reviewed by Adam Gardner, Licensed Pharmacist & COO of TelyRx

Mariah Powers
September 9, 2025

If you’ve ever been prescribed medication for anxiety, chances are it was either an SSRI. And if it didn’t sit right with you—if it numbed you, made your heart race, killed your sex drive, or just didn’t help—you probably wondered why it felt like the only option. You’re not alone.

Anxiety is one of the most common mental health struggles in the world, yet the treatment conversation is strangely narrow. Despite over 40 million U.S. adults living with anxiety each year, most are offered the same script: take a daily SSRI, maybe add a stimulant if you’re also struggling to focus, and hope for the best. But what if that’s not what’s best?

This piece is for those who’ve been told medication was their only way out, only to find it wasn’t the right fit. It’s for those searching for relief without sedation, support without side effects, and care that respects your right to feel like yourself again. If you’ve ever asked yourself how you can manage anxiety without SSRIs or wondered whether alternative anxiety meds could work for you, this is what no one tells you but should.

how SSRIs and stimulants became the default

To understand how we got here, we must go back. In the 1980s, mental health care shifted dramatically with the rise of SSRIs. These medications promised something revolutionary: a way to treat depression and anxiety with fewer side effects than older drugs.

For many, they delivered. SSRIs quickly became first-line treatments, endorsed by national guidelines and covered by insurance, thanks to a surge in pharmaceutical marketing and provider training built around them.

Stimulants followed a similar trajectory. As ADHD diagnoses rose—particularly in women and adults—stimulants like Adderall and Vyvanse were increasingly prescribed off-label for people with anxiety, especially those reporting brain fog, restlessness, or trouble concentrating.

But here’s what got lost in the standardization: nuance. Medications that were meant to help started being handed out in five-minute appointments, with little conversation about root causes or long-term effects. SSRIs were assumed to be “gentle” and “non-habit forming.” Stimulants were framed as productivity tools. The complexity of anxiety, including its ties to trauma, environment, nervous system patterns, and even gut health, got flattened into a chemical imbalance theory that doesn’t hold up for everyone.

Today, SSRIs and SNRIs are among the top fifteen most prescribed medications in the U.S., yet over a quarter of people stop taking them within three months. Many cite emotional numbness, sexual side effects, or worsening anxiety. Stimulants, for their part, help some; but up to 50% of users experience increased anxiety, panic, or insomnia (NIH review).

We don’t question the dominance of these drugs because they’ve become routine. But routine isn’t the same as right. And for millions of people quietly struggling with side effects, dependency, or the sense that their treatment is working against them, routine feels like a trap.

That’s where the conversation needs to change. Because there are options. And for many people, those options have better outcomes.

why SSRIs and stimulants may not feel right

For many people, SSRIs or stimulants bring significant downsides. Up to 55% of SSRI users report sexual dysfunction. As many as 30% discontinue SSRIs within the first three months due to side effects (Harvard Health Publishing array). Common complaints include emotional numbness, insomnia, sedation, restlessness, or fear of dependency and withdrawal.

Stimulants often backfire in anxiety management. Instead of improving focus and brain fog, they can heighten physical symptoms like tightness in the chest, racing heart, and panic, making anxiety worse.

For many, the experience feels like trading one problem for another. This is especially true if your anxiety is rooted in being overwhelmed, PTSD, trauma, or life stress rather than a chemical imbalance. In response, people are increasingly searching for alternatives and natural remedies for anxiety.

ways to manage anxiety without SSRIs

1. Prescription Options That Don’t Create Dependency

Propranolol is a non-stimulant beta blocker used to calm physical symptoms like trembling hands, racing heart, or sweaty palms. It’s commonly used for performance-related anxiety but can be helpful in acute anxiety moments too. Because it doesn’t act on brain serotonin, it carries less risk for emotional side effects.

Hydroxyzine is an antihistamine with FDA-approved calming properties. Multiple studies show it is as effective as benzodiazepines for short-term anxiety without causing dependence. Its sedating effect can also help ease nighttime anxiety. TelyRx facilitates access to both options as needed, with no long-term commitment or video appointments required.

Starting at $19.99

Hydroxyzine

Due to its effects on certain receptors in the brain, Hydroxyzine can be used to treat anxiety and tension.

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Starting at $19.99

Propranolol

Propranolol is used for the treatment of performance anxiety, public speaking, or other situational events.

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2. Mind-Body Practices That Create Long-Term Change

When you’re managing anxiety without SSRIs, the goal is to retrain your nervous system. This means working with your body, not against it.

Your stress response is biological. It’s the result of a hyperactive nervous system stuck in fight-or-flight mode, sometimes from trauma, sometimes from chronic overstimulation. Medications can mute this response, but they rarely change how your body reacts to future stress. That’s where mind-body practices come in.

Breathwork is one of the most accessible and research-backed tools. Simple techniques like box breathing, alternate nostril breathing, or extended exhales (such as 4-7-8 breathing) have been shown to reduce anxiety symptoms by up to 30–40% with regular use. A 2023 randomized trial found that daily diaphragmatic breathing reduced cortisol levels and improved anxiety scores significantly after just four weeks.

Cognitive Behavioral Therapy (CBT) remains one of the most effective non-drug approaches to anxiety. It teaches you how to reframe thought patterns, challenge irrational beliefs, and develop healthier reactions to stress triggers. According to the APA, CBT performs as well as medication in treating many anxiety disorders (and has a lower relapse rate once discontinued).

Then there’s the vagus nerve—a key player in regulating your parasympathetic nervous system (the part that calms you down). You can activate this nerve naturally with cold exposure (like a cold shower or splash of water on the face), slow humming, and extended exhalations. These techniques literally signal to your body that you’re safe, helping it shift out of panic and back into equilibrium.

If your anxiety is rooted in trauma or stored physical tension, somatic practices may be even more impactful. Modalities like EMDR, somatic experiencing, and trauma-informed yoga therapy go beyond the mind and help your body discharge fear held at a cellular level. These practices may take longer to show results, but the effects can be more transformative than any pill.

Anxiety may start in your thoughts, but healing often begins in your body. The more consistently you train your nervous system to find calm, the more those moments of panic lose their grip.

3. Supplements, Foods, and OTC Tools That Can Support You

If you’re trying to manage anxiety without SSRIs, it’s easy to feel like there’s nothing in between “pharmaceutical” and “just breathe through it.” But the truth is, there’s a growing body of research supporting natural compounds and food-based strategies that, while not cures, can significantly reduce symptoms.

Let’s start with magnesium glycinate, one of the most promising supplements for anxiety support. A 2017 meta-analysis published in PLOS ONE found that magnesium supplementation led to mild but statistically significant improvements in anxiety symptoms across both general and clinical populations. Glycinate is a preferred form because it’s gentle on digestion and better absorbed.

L-theanine, an amino acid found naturally in green tea, promotes calm alertness. It’s known for smoothing over anxious thoughts without sedation, making it ideal for those who want relief without fog. Ashwagandha and rhodiola are also gaining popularity. Small clinical trials have shown reductions in perceived stress and cortisol levels, though larger studies are still needed.

Many are also turning to CBD and hemp-derived products. While evidence is mixed and quality varies greatly by brand, some studies suggest that CBD may reduce anxiety by influencing serotonin and GABA receptors. If you go this route, be cautious about dosage, legality in your state, and sourcing; look for third-party lab verification.

Then there’s food. What you eat directly influences your mood through the gut-brain axis. Foods rich in probiotics (like kefir, yogurt, or fermented vegetables) and prebiotics (like oats, garlic, or bananas) may support a calmer baseline over time. Herbal teas like chamomile, passionflower, and lemon balm have mild sedative properties and can be used situationally.

Even dark chocolate, when consumed in moderation, can boost serotonin and lower cortisol thanks to flavonoids and magnesium content.

It’s worth noting that some common over-the-counter choices, like Benadryl or sleep aids, are often misused for their calming effects. These may seem harmless, but over time they can lead to dependence, grogginess, and rebound anxiety. The same is true of alcohol—while it may numb anxiety in the moment, it can worsen symptoms long-term.

The goal here isn’t to replace one crutch with another. It’s to build a toolkit that works gently with your body, offers fewer side effects, and supports your long-term mental health. If SSRIs and stimulants have failed you, you’re not out of options. You’re just getting started.

what to know about transitioning off anxiety medication

If SSRIs or stimulants haven’t worked for you or have started to feel like more of a burden than a solution, it’s completely valid to consider stepping away from them. But like any big shift in mental health care, how you do it matters just as much as why.

Coming off anxiety medication, especially SSRIs, isn’t always straightforward. Many people experience physical and emotional withdrawal symptoms like nausea, sleep disruptions, mood swings, or a resurgence of anxiety that can feel overwhelming if you’re not prepared. That’s why the first and most important step is to talk to a licensed provider before making any changes. With the right tapering plan, this transition can be safe and manageable.

There are also tools that can help you bridge the gap. Non-stimulant anxiety medications don’t require long-term commitment and can support your nervous system as you step away from daily prescriptions. These aren’t replacements for a plan, but they can make the process more stable and less disruptive.

Mind-body practices, like breathwork and CBT, and natural supports like magnesium or L-theanine, are essential allies—but even these work best when added gradually, not in a panic. Mental health isn’t all-or-nothing. With the right support, that next chapter doesn’t have to feel uncertain. It can feel like relief.

medication isn’t one-size-fits-all—and you don’t have to settle

You are the expert on your mind and body. If you’ve experienced side effects, dependency concerns, or simply feel uneasy about long-term use, those concerns are valid reasons, and so are your options.

While SSRIs and stimulants help some people, they’re not the only path forward. Through evidence-based alternatives like non-stimulant anxiety medications, therapy, breathwork, supplements, or lifestyle adjustments, you can regain a sense of calm and control that feels sustainable.

If you’re seeking a path that respects your autonomy, TelyRx is here for you. We believe in accessible, empathetic care that honors your unique journey.

Disclaimer

This blog post is for informational purposes only and does not constitute medical advice, diagnosis, or treatment. The content provided here is not a substitute for professional medical advice, consultation, or care from a qualified healthcare provider. Always seek the guidance of your physician or another licensed health professional with any questions you may have regarding a medical condition or treatment. Do not disregard or delay seeking professional medical advice based on information read on this site. Learn more about our editorial standards here.

Explore your anxiety management options beyond SSRIs.