Sacubitril/valsartan, the generic form of Entresto, is a prescription medication commonly used to treat heart failure with reduced ejection fraction (HFrEF). It combines two active ingredients: sacubitril, a neprilysin inhibitor that helps increase levels of beneficial peptides to improve blood flow and reduce fluid buildup, and valsartan, an angiotensin II receptor blocker (ARB) that lowers blood pressure by relaxing blood vessels. Together, they help reduce strain on the heart, improve its efficiency, and lower the risk of hospitalization and cardiovascular death in heart failure patients. This medication is typically taken twice daily and is part of a long-term treatment plan under the supervision of a healthcare provider.
- Sacubitril/valsartan is the generic version of Entresto, used to treat heart failure with reduced ejection fraction (HFrEF).
- It is a combination medication containing sacubitril (a neprilysin inhibitor) and valsartan (an angiotensin II receptor blocker or ARB).
- Sacubitril increases natriuretic peptides, which promote blood vessel relaxation and sodium excretion.
- Valsartan blocks angiotensin II receptors, helping to reduce blood pressure and prevent fluid retention.
- Together, these actions help lower strain on the heart and improve cardiac function.
- Typically prescribed for patients with chronic heart failure with reduced ejection fraction (HFrEF).
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Sacubitril / Valsartan Tablets Side Effects
Sacubitril/valsartan (Generic Entresto®) tablets side effects may include dizziness, low blood pressure (hypotension), and fatigue, especially when starting the medication or increasing the dose. Some patients may experience elevated potassium levels (hyperkalemia), which can lead to muscle weakness or irregular heart rhythms, as well as decreased kidney function. Cough and gastrointestinal symptoms such as nausea or diarrhea may also occur. A serious but less common side effect is angioedema, a swelling of the face, lips, tongue, or throat that can impair breathing and requires immediate medical attention. This risk is higher in patients with a history of angioedema or in those switching from ACE inhibitors without the recommended 36-hour washout period.
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Consumer Information Use and Disclaimer
This information should not be used to decide whether or not to take this medicine or any other medicine. Only a healthcare provider has the knowledge and training to decide which medicines are right for you. TelyRx does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a limited summary of general information about the medicine’s uses from the patient education materials and is not intended to be comprehensive. This limited summary does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not intended to provide medical advice, diagnosis or treatment and does not replace information you may receive from your healthcare provider. For a more detailed summary of information about the risks and benefits of using this medicine, please review the entire patient education information you receive with the medication.
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