Enalapril is a medication used in the management of cardiovascular diseases, particularly hypertension and heart failure. As an ACE inhibitor, it targets the renin-angiotensin-aldosterone system (RAAS), a hormonal system that regulates blood pressure and fluid balance. By inhibiting the enzyme that converts angiotensin I to angiotensin II, enalapril reduces vasoconstriction and lowers aldosterone secretion, leading to decreased blood pressure and reduced workload on the heart
In clinical practice, enalapril is valued for its efficacy, tolerability, and long duration of action. It is often part of a comprehensive treatment plan that may include lifestyle changes and other medications. For heart failure patients, enalapril has demonstrated benefits in reducing symptoms, improving exercise tolerance, and lowering the risk of hospitalization and death. The use of enalapril requires careful monitoring, especially in patients with kidney disease or those taking other medications that affect potassium levels or blood pressure.