Uses, Side Effects, Dosage, and FAQs (2026 Guide)
Diclofenac sodium is a prescription non-steroidal anti-inflammatory drug (NSAID) used to manage pain and inflammation associated with osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis (a type of arthritis that affects the spine). Beyond chronic joint conditions, it is also used to treat acute pain from primary dysmenorrhea (painful menstrual periods) and migraines.
Diclofenac sodium comes in oral and topical formulations. Common side effects include constipation, diarrhea, stomach pain, headache, and nausea.
Diclofenac sodium works by inhibiting an enzyme called cyclooxygenase (COX), which plays a role in the body’s production of prostaglandins — chemical messengers that trigger pain and inflammation.
When you have a condition like arthritis, your body produces excess prostaglandins, leading to the pain, swelling, and stiffness you feel in your joints or muscles. By blocking the COX enzyme, diclofenac sodium helps reduce the levels of these prostaglandins and the related inflammation and discomfort.
| Quick Facts | |
|---|---|
| Common Brands | Voltaren XR, Cataflam, Zipsor, Zorvolex, Cambia |
| Drug Class | Non-steroidal anti-inflammatory drug (NSAID) |
| Generic Status | Generic for Voltaren XR, Cataflam, Zipsor, Zorvolex, Cambia |
| Availability | Prescription only |
The dosage of oral diclofenac sodium depends on what you’re taking it for. Delayed release tablets are typically taken twice a day.
The diclofenac sodium topical solution is applied directly to clean, dry skin on the affected area up to four times daily.
Note: Dosing information is educational only. Your prescribing physician will determine your specific dose based on your individual health needs. Always follow your healthcare provider’s instructions for exact dosing.
FDA-Approved Uses
Diclofenac sodium is FDA-approved to treat:
Off-Label Uses
You may see diclofenac sodium prescribed for uses that are not “FDA-approved.” This is a very common and legal practice called “off-label” prescribing, where a doctor uses their clinical judgment to prescribe a drug for a different (but well-researched) purpose.
Diclofenac sodium may be prescribed off-label for gout, acute pain, and other inflammatory conditions.
Join our mailing list for exclusive deals and more.
Like all medications, diclofenac sodium can cause side effects. Some common side effects may improve over time as your body adjusts to the medication. Other side effects may be serious and require medical attention.
Common Side Effects
Serious Side Effects
Serious side effects are rare, but it’s important to know what to look for if they do occur. Stop using diclofenac sodium and call your doctor immediately if you experience:
Call your doctor immediately if you experience any concerning or prolonged symptoms.
Always swallow tablets whole with a full glass of water. Taking diclofenac sodium with food or milk may help reduce stomach upset.
Drinking alcohol while taking diclofenac sodium may increase the risk of stomach bleeding.
This medication can make your skin more sensitive to sunlight (photosensitivity). You may burn more easily. Wear sunscreen and protective clothing if you need to be outdoors.
It is typically not recommended to use diclofenac when pregnant as it may cause harm to the unborn baby and complications during delivery.
If you miss a dose of diclofenac sodium, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed one and continue your regular schedule. Do not take double or extra doses to make up for a missed one.
Certain medications and substances can interact with diclofenac sodium, potentially altering how it works or increasing the risk of side effects. For example:
Always give your doctor and pharmacist a complete list of all your medications, vitamins, and supplements to check for potential interactions.
The main difference lies in how quickly the body absorbs them. Diclofenac potassium dissolves faster in the stomach. Diclofenac sodium comes in delayed-release tablets that dissolve in the intestine for longer lasting pain relief.
If using diclofenac gel, it is recommended to wait until the gel has completely dried before applying sunscreen, lotion, or insect repellant to the same area. Applying other products too soon can alter the absorption of the medication and cause skin irritation.
Generally, no. Ibuprofen, aspirin, and naproxen are all NSAIDs, just like diclofenac. Taking them together increases the risk of serious stomach bleeding and ulcers.
Yes, diclofenac can lead to new high blood pressure or worsening of existing high blood pressure. If you have hypertension, monitor your blood pressure closely while taking this medication.
If using the diclofenac sodium gel, it is recommended to wait at least an hour before showering or swimming to ensure the medication has been absorbed into the skin.
It is generally not recommended, especially in the later stages. You should specifically avoid taking diclofenac at 20 weeks or later in pregnancy, as it can cause harm to the fetus and complications during delivery. Always consult your doctor if you are pregnant or trying to conceive.
Yes, diclofenac gel is commonly prescribed for osteoarthritis pain in accessible joints like the knees, hands, wrists, feet, and elbows.
No, diclofenac is a non-steroidal anti-inflammatory drug (NSAID), not a muscle relaxer. It relieves pain by reducing inflammation, whereas muscle relaxers work by targeting the central nervous system to reduce muscle spasms.
It is recommended to avoid alcohol while taking diclofenac. Both alcohol and diclofenac can irritate the stomach lining. Combining them increases the risk of gastric bleeding and ulcers.
Diclofenac is extremely toxic to animals, particularly cats and dogs. Even small amounts ingested by licking a treated area can cause kidney failure and death in pets. If using gel, wash your hands thoroughly after application.
No. You should never apply diclofenac gel to open wounds, cuts, infections, or skin with a rash. It should only be applied to healthy, intact skin that is clean and dry.
Diclofenac is FDA-approved for inflammatory pain (like arthritis) and is not considered a first-line treatment for neuropathic (nerve) pain, which is typically treated with different classes of medications like anticonvulsants or antidepressants.
Voltaren is a brand name for plain diclofenac. Arthrotec is a combination drug that contains both diclofenac and misoprostol. The misoprostol component is added to help protect the stomach lining from ulcers.
It’s recommended to avoid applying bandages or wraps to the area treated with diclofenac gel, as this can increase absorption to dangerous levels or cause skin burns. Breathable, loose clothing is usually acceptable.
It is recommended to use the lowest effective dose of diclofenac for the shortest amount of time needed. For the gel, treatment may be limited to 21 days unless otherwise directed by a physician.
There are several medications that your doctor can prescribe in place of diclofenac sodium. Here are a few possible alternatives below.
A faster-acting form of diclofenac used for acute pain relief from arthritis, migraines, and menstrual cramps.
A prescription NSAID used for osteoarthritis and rheumatoid arthritis.
Another prescription NSAID used for osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
A prescription NSAID used for acute pain, gout, osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and bursitis.
A combination drug that contains diclofenac with misoprostol, a stomach-protecting agent, to reduce the risk of developing gastric ulcers or bleeding.
Important: Information on this page is for educational purposes only. Prescribing decisions are made by independent, licensed providers. TelyRx operates technology-enabled pharmacies and a telehealth platform that connects patients with board-certified licensed providers. Prescriptions, when provider-approved and issued, are filled and shipped by TelyRx-affiliated pharmacies. We do not employ physicians or make prescribing decisions. Learn more about our editorial standards here.
