How It Works
Qelbree works by:
- Blocking norepinephrine: It blocks the reuptake or reabsorption of norepinephrine in the brain.
- Increasing signaling: By keeping more norepinephrine available in the spaces between brain cells (the synapses), it strengthens the signals related to attention and self-regulation.
- Selective targeting: Unlike stimulants that often impact dopamine levels significantly, Qelbree focuses on the norepinephrine system.
This increased chemical activity helps the brain’s executive function centers work more efficiently. Over time, this can lead to better organization, better ability to stay on task, and reduced hyperactive behaviors.
| Quick Facts | |
|---|---|
| Common Brands | Qelbree |
| Drug Class | Selective norepinephrine reuptake inhibitor |
| Generic Status | No generic version is currently available |
| Availability | Prescription only |
Dosing
Qelbree dosing is tailored to the patient’s age and their specific response to the medication. It is usually taken once a day.
- Starting doses: Doses typically begin at 200 mg daily.
- Gradual adjustment: If symptoms require more control, a doctor may increase the daily dose by 100-200 mg per week.
- Maximum limits: The maximum recommended daily dose is 600 mg.
- Administration: It’s generally recommended that you swallow capsules whole with water. If swallowing pills is difficult, you can open the capsule and sprinkle the contents on a teaspoon of applesauce or pudding. Providers advise against chewing or crushing the granules. You can eat the mixture within 15 minutes with pudding or two hours with applesauce.
- Timing: Qelbree may be taken with or without food. Taking it at the same time each day helps maintain steady levels in your system.
Standard guidelines indicate that it may take a week or longer to notice symptom improvement, with the full effect taking several weeks to develop.
Note: Dosing information below is educational only. Your prescribing physician will determine your specific dose based on your individual health needs. Always follow your healthcare provider’s instructions for exact dosing.
Uses
FDA-Approved Uses
Qelbree is FDA-approved to improve focus and reduce impulsive behavior in people with ADHD.
Off-Label Uses
You may see Qelbree prescribed for uses that are not “FDA-approved.” This is a common and legal practice called “off-label” prescribing, where a doctor uses their clinical judgment to prescribe a drug for a different (but well-researched) purpose.
Qelbree may be prescribed for the following conditions:
- Depression symptoms: Because viloxazine was originally researched and used in other countries as an antidepressant, some doctors may prescribe it for patients dealing with both ADHD and mood disorders.
- Emotional dysregulation: Some providers use Qelbree to help stabilize the intense emotional outbursts that can sometimes accompany ADHD.
Get Savings Updates for Qelbree
Join our mailing list for exclusive deals and more.
Side Effects
Like any medication that affects brain chemistry, Qelbree can cause side effects. Many are mild and tend to improve as your body adjusts to the medication.
Common Side Effects
- Sleep changes: This includes both drowsiness (feeling tired) and insomnia (trouble falling asleep)
- Digestive issues: Nausea, vomiting, constipation, or an upset stomach
- Appetite changes: Decreased hunger, which could lead to weight changes over time
- General symptoms: Headache, fatigue, dry mouth, or irritability
Serious Side Effects
It’s generally advised that you stop taking the medication and immediately call the doctor if you experience any of the following:
- Suicidal thoughts: This medication can increase the risk of suicidal thoughts or actions, especially in the first few months of treatment or during dose changes. Providers suggest monitoring for any unusual changes in mood or behavior.
- Increased heart rate and blood pressure: Qelbree can cause your heart to beat faster or your blood pressure to rise.
- Mania: In people with a history of bipolar disorder, Qelbree may trigger a manic episode (excessive energy, racing thoughts, or reckless behavior).
- Severe allergic reaction: Standard guidelines recommend monitoring for hives, facial or throat swelling, or shortness of breath.
Call your doctor immediately if you experience any concerning or prolonged symptoms.
Pharmacist Tips
Be Patient With Results
Non-stimulants do not work as quickly as stimulants. It is common to wait one to two weeks for initial changes and several weeks for the full benefit.
Watch Your Caffeine Intake
Qelbree can significantly increase caffeine levels in your body. This could make you feel jittery and anxious, or cause your heart to race. It is generally recommended to limit or stop drinking caffeinated coffee, tea, and soda while taking this medication.
Check Your Vital Signs
Since Qelbree can raise your heart rate and blood pressure, providers typically suggest checking these at home and keeping a log for your follow-up visits.
Manage Drowsiness
If Qelbree makes you feel sleepy during the day, it’s generally accepted that you talk to your doctor. They may suggest taking it in the evening instead. Standard guidelines advise against driving or using machinery until you know how the drug affects your alertness.
The Applesauce Trick
If you sprinkle the capsule contents on food, providers generally don’t recommend that you chew the granules. Chewing them disrupts the extended-release system and may cause the medicine to enter your system all at once.
Stay Hydrated
Dry mouth is a common side effect. Drinking plenty of water or using sugar-free lozenges can help.
Drug Interactions
Qelbree can change how your body processes other medications, which can lead to higher levels of those drugs in your bloodstream.
Let your doctor know if you take any of the following:
- Caffeine: Qelbree is a strong inhibitor of the enzyme that metabolizes caffeine, which may increase caffeine toxicity.
- Duloxetine (Cymbalta): Taking these together can dangerously increase duloxetine levels.
- Monamine oxidase inhibitors (MAOIs): Standard guidelines advise against taking Qelbree within 14 days of taking a monoamine oxidase inhibitor (used for depression), as this can cause a life-threatening spike in blood pressure.
- Theophylline: This lung medication can reach toxic levels if taken with Qelbree.
- Tizanidine (Zanaflex): This muscle relaxant can cause severe sleepiness or low blood pressure when combined with Qelbree.
- Warfarin: Qelbree may interact with blood thinners, requiring more frequent testing of your clotting time.
Always give your doctor and pharmacist a complete list of all your medications, vitamins, and supplements to check for potential interactions.
FAQs
Is Qelbree a stimulant like Adderall or Ritalin?
No. Stimulants increase the activity of dopamine and norepinephrine quickly. Qelbree is a non-stimulant that works more slowly and specifically on norepinephrine.
Why is it recommended to stop drinking coffee or caffeine while taking Qelbree?
Qelbree prevents your body from breaking down caffeine efficiently. This can make a single cup of coffee feel like several, leading to jitters, a racing heart, or trouble sleeping.
Does Qelbree work immediately, or does it take time to build up?
It takes time. People usually notice a difference after two weeks. Optimal effects often take several weeks of consistent dosing.
Is Qelbree a controlled substance (narcotic)?
No. It is not a narcotic and is not regulated like stimulants.
Does this medication cause insomnia or drowsiness?
It can cause both. Your doctor may adjust the timing of your dose to help manage this.
Can I take Qelbree if I have a history of bipolar disorder?
Standard guidelines suggest caution. Qelbree can trigger manic episodes in people with bipolar disorder. It’s generally advised that you discuss your full psychiatric history with your doctor.
Does Qelbree suppress appetite?
Yes, decreased appetite is a common side effect. It is a good idea to monitor your weight and ensure you are eating nutritious meals throughout the day.
What happens if I miss a dose?
Providers recommend taking it as soon as you remember. However, if it is almost time for your next dose, skip the missed one. Standard guidelines advise against taking two doses at the same time.
Is Qelbree safer for my heart than stimulant medications?
While it is a non-stimulant, it can still increase heart rate and blood pressure. Providers typically recommend the same level of heart monitoring as they do for stimulant treatments.
Can I take Qelbree with other ADHD medications like Intuniv?
Some providers may prescribe Qelbree alongside other non-stimulants or stimulants. This must be managed carefully by your doctor to monitor for interactions.
Is it safe to take this medication during pregnancy?
It is generally accepted that Qelbree should only be used during pregnancy if the potential benefit outweighs the potential risk to the mother and unborn baby. If you become pregnant while taking this medication, your doctor may suggest joining a pregnancy registry to help monitor the health of you and your baby.
Does Qelbree show up on a drug test?
Qelbree is not an amphetamine or a stimulant, so it typically does not trigger a positive result on standard workplace drug screens for controlled substances.
How is Qelbree different from Strattera (atomoxetine)?
Both are non-stimulants that target norepinephrine. However, they are processed by different enzymes in the liver and have different chemical structures. Some patients who do not respond to Strattera find relief with Qelbree.
Can I stop taking Qelbree suddenly, or do I need to taper off?
Standard guidelines suggest that you should not stop taking any psychiatric medication suddenly without talking to your doctor. They will help you taper off safely to avoid potential withdrawal symptoms like headache or irritability.
Does Qelbree help with anxiety as well as ADHD?
There is currently no evidence that Qelbree treats anxiety, as it has not been studied for that purpose.
Can I drink alcohol while taking this medication?
Alcohol can worsen the drowsiness and dizziness caused by Qelbree. It is usually recommended to avoid alcohol while taking this medication.
Comparable Medications
Strattera, Intuniv, Kapvay, Adderall XR, Concerta, or Wellbutrin?
Below are some potential alternatives to Qelbree:
Strattera
A non-stimulant that also targets norepinephrine. It is taken once or twice daily and has a different metabolic pathway than Qelbree.
Intuniv
A non-stimulant that works on different brain receptors to lower blood pressure and reduce impulsivity. It is commonly used as an add-on therapy.
Kapvay
A non-stimulant commonly used to help with hyperactivity and sleep, but it typically causes more sedation than Qelbree.
Adderall XR
A stimulant and controlled substance that works quickly on both dopamine and norepinephrine.
Concerta
A long-acting stimulant that primarily increases dopamine levels. It is used for immediate focus but may cause more anxiety in some patients.
Wellbutrin
An antidepressant sometimes used off-label for ADHD. It is not FDA-approved for ADHD and may be less effective than Qelbree for specific symptoms.
We Have Qelbree in Stock. Get Yours Today!
Important: Information on this page is for educational purposes only. Prescribing decisions are made by independent, licensed providers. TelyRx operates technology-enabled pharmacies and a telehealth platform that connects patients with board-certified licensed providers. Prescriptions, when provider-approved and issued, are filled and shipped by TelyRx-affiliated pharmacies. We do not employ physicians or make prescribing decisions. Learn more about our editorial standards here.