Key Takeaways
- Some telehealth platforms offer virtual visits for a diagnosis, while others let you request a medication you already know you need.
- Insurance-based platforms cost less if your plan covers them, while cash-pay platforms often suit uninsured patients.
- Membership fees can add to your visit and medication costs on certain platforms, so it’s important to compare total prices.
Getting a prescription used to mean taking time off work and sitting in a waiting room. Telehealth has changed that, letting you manage an ongoing condition or find an affordable mail-order prescription service from home.
Provider access is still a hurdle for many people. A recent TelyRx survey of adults who manage an ongoing prescription found that 10% consider it their biggest barrier to getting their medication consistently.
Telehealth providers vary widely in how they deliver care and what they charge. We compared nine of them by cost and the type of care they offer to help you find the right fit for your needs.
The Best Telehealth Platforms at a Glance
| Platform | Best For | Care Focus | Pricing Model |
| TelyRx | Direct on-demand care | Acute and chronic care prescriptions | Clear per-item cash pay |
| Ro | Weight loss and general wellness | GLP-1s, ED, STIs, skincare | Recurring product subscription |
| Hims | Men’s health and hair loss | Hair, ED, mental health, GLP-1s | Recurring product subscription |
| Amazon One Medical | Prime member primary care | Comprehensive primary care | Annual membership plus visit fees |
| Sesame | Uninsured marketplace care | Primary and urgent care | Pay-per-visit, optional membership |
| PlushCare | Insured primary care | Chronic and daily wellness | Monthly membership plus copay |
| Nurx | Specialized reproductive health | Birth control, STIs, acne | Flat review fee plus order costs |
| GoodRx Care | Discounted quick consultations | Common refills and acute needs | Flat consultation fee |
| Amwell | Insurance-backed urgent care | Urgent care, mental health, and chronic illness | Insurance billing or flat cash fee |
1. TelyRx

- Best for: Affordable access to a wide range of everyday medications
- Medicines offered: 500+ FDA-approved, non-controlled medications for chronic and acute conditions (including blood pressure, cholesterol, and everyday illness medications)
- Pricing: $22 provider review fee + transparent, cash-pay pricing
TelyRx is a digital pharmacy platform that connects provider review, pharmacy fulfillment, and discreet delivery. Our straightforward pricing means you can get treatment privately without dealing with deductibles or unexpected copay changes.
You can order medications as needed for everyday conditions like asthma and high blood pressure, with no mandatory subscription. If you already know what you need, submit a health and physical attestation, and an independent, state-licensed provider will review your request. Once approved, your medication ships directly to your door.
Pros:
- No insurance required, so you avoid deductibles and coverage denials
- Transparent, upfront cash pricing with no hidden fees
- Fast shipping directly to your door in plain, unmarked packaging
- Wide range of medications on one platform, without a mandatory monthly membership
Cons:
- No live appointments or diagnoses, so you need to know which medication you need
- No controlled substances
The medications you need, exactly when you need them.
Skip the mandatory memberships and order your everyday health treatments on demand.
2. Ro

- Best for: Weight management and adult health programs
- Medicines offered: A wide range of treatments, including sexual health prescriptions for ED and STIs, hair loss solutions, customized skincare, and GLP-1 weight loss medications
- Pricing: Subscription-based (varies by medication, includes medical evaluation)
Ro, which originally launched as the men’s health platform Roman, now offers telehealth services for both men and women, covering areas such as weight management, sexual health, and skincare.
The service operates on a subscription model: After a licensed provider reviews your online health profile and approves treatment, your medication ships in unmarked boxes on a recurring schedule.
If you’re managing a few of Ro’s specialized conditions at once, Ro makes it easy to keep them in one place.
Because the platform requires an ongoing subscription, though, it’s not the best match if you just want a single prescription fill without committing to a recurring plan.
Pros:
- Consolidates multiple specialized health goals like weight management, hair care, and sexual wellness into a single platform
- Predictable auto-ship schedule ensures you never run out of treatment
- Sleek digital health tracking interface to monitor long-term progress
Cons:
- Requires an ongoing subscription commitment for ongoing care
- Does not cover general primary care needs or everyday medications
3. Hims

- Best for: Men’s wellness, hair loss, and sexual health treatments
- Medicines offered: Prescriptions for erectile dysfunction, hair regrowth, and GLP-1 weight management, along with medications for anxiety, depression, and skincare
- Pricing: Subscription-based (billed monthly or quarterly, depending on the plan)
Hims is a telehealth brand focused on men’s health, including sexual wellness, hair regrowth, mental health support, and skincare. They also offer options such as chewable mint formulations of certain medicines to help combat pill fatigue.
If you know which ongoing treatment you want and prefer automatic deliveries, Hims offers a predictable shipping schedule. However, the focus on men’s health means it isn’t built for broader primary care needs, so if you need a wider range of everyday medications, these Hims alternatives may be a better fit.
Pros:
- Unique, alternative compounded medication formats like chewables
- Convenient autopilot refills for long-term lifestyle treatments
- Curated selection of men’s health-focused medicine like ED and hair loss
Cons:
- Recurring billing and subscription commitments
- Not ideal for treating general illnesses and conditions
- Compounded medications are not FDA-approved
4. Amazon One Medical

- Best for: Prime members seeking 24/7 primary care access
- Medicines offered: Full spectrum of chronic and acute primary care prescriptions (including blood pressure, cholesterol, and everyday illness medications)
- Pricing: Annual membership fee + per-visit or insurance copay fees, or standalone pay-per-visit fees
Amazon One Medical offers two ways to get care. A membership gives you 24/7 on-demand virtual care at no extra cost, plus the option to book in-person visits at One Medical offices in select cities.
In case you don’t want a membership, On-Demand Care lets you request one-time virtual care for 30+ common conditions, like pink eye or a sinus infection, via direct messaging or video. A provider determines what’s medically appropriate and sends any prescriptions to the pharmacy of your choice.
Pros:
- 24/7 virtual on-demand care included with membership
- Option to book in-person appointments at physical clinic locations
- Seamless integration into the existing Amazon app ecosystem, complete with discounted rates for Prime members
Cons:
- Mandatory annual membership fee to access the portal and book care
- Additional out-of-pocket costs for doctor visits and medications, which are not included in the membership
5. Sesame

- Best for: Cash-pay, no-insurance virtual appointments
- Medicines offered: Primary care, urgent care, mental health, and specialist prescriptions (written by the doctor to be filled at your pharmacy of choice)
- Pricing: Pay-per-visit marketplace pricing
Sesame functions as a direct medical marketplace that pairs patients with local and national healthcare providers for flat-fee, cash-pay appointments. You can browse providers, compare pricing, and book a visit, often on the same day.
However, because Sesame requires live video visits, you have to schedule and attend a live call to get your prescription. When you already know your diagnosis and feel confident in your treatment, booking and waiting for a live appointment adds an extra layer of planning.
Pros:
- Clear, upfront cash pricing with no hidden facility or surprise insurance fees
- Hand-pick your own independent doctor based on reviews and pricing
- No mandatory platform memberships or ongoing monthly subscriptions required
Cons:
- Requires booking and attending a live video appointment to get care
- Medication costs are handled separately and are not bundled into the visit fee
- Sesame does not offer prescription shipping. Instead, you must pick up the medication at a local pharmacy.
6. PlushCare

- Best for: Primary care visits with insurance coverage
- Medicines offered: Full range of standard primary care, chronic condition, and daily wellness medications (including antibiotics, blood pressure meds, and antidepressants)
- Pricing: Monthly subscription fee + insurance copay or cash visit fees
PlushCare works like a traditional doctor’s office, using scheduled video calls with licensed doctors. They accept most major health insurance plans, which helps keep your out-of-pocket visit costs as low as possible if you have compatible coverage.
If you want an ongoing relationship with a dedicated primary care doctor, you can choose a physician and keep seeing them over time. The tradeoff here is cost.
PlushCare requires a monthly membership fee on top of the per-visit fee, though one membership covers you and up to five family members.
Pros:
- Accepts most major commercial health insurance plans to help offset appointment costs
- Live video appointments with licensed primary care physicians
- Ideal for tracking complex, long-term chronic conditions that need laboratory orders
Cons:
- Charges a mandatory monthly membership fee just to use the platform
- Prescriptions must be picked up in person at a local retail pharmacy rather than being shipped home
7. Nurx

- Best for: Women’s health, including birth control and reproductive care
- Medicines offered: Birth control, emergency contraception, HIV PrEP, STI testing kits, acne treatments, and anti-aging topicals
- Pricing: Physician review fee + medication costs (accepts cash or insurance)
Nurx offers specialty care for women, covering birth control, menopause, mental health, weight management, and skincare. This platform does not offer live consultations. Instead, you complete an online consultation, and a provider licensed in your state reviews it and prescribes treatment if appropriate.
If you want a specialized space to manage your reproductive wellness or regular acne care with automated, routine shipping, Nurx simplifies the entire process.
Though, its focus on women’s health means it isn’t built for broader primary care needs.
Pros:
- Clinical specialization and privacy for sensitive reproductive health needs
- Asynchronous medical reviews let you submit health details entirely on your own time
- Automated home delivery of recurring medications to avoid coverage gaps
Cons:
- Not ideal for treating general illnesses and conditions
8. GoodRx

- Best for: Prescription discounts paired with affordable virtual visits
- Medicines offered: Short-term acute care medications (such as antibiotics, antivirals), and routine refills for conditions like asthma, cholesterol, and hypertension
- Pricing: Flat-fee consultation per visit
GoodRx Care provides access to online doctor visits alongside discounts on medications. Your consultation can take place via text, phone, or video, depending on your location and specific health needs.
This is a great option if you prefer picking up your medicine at a local pharmacy, since prescriptions are sent there for same-day pickup.
GoodRx Care doesn’t offer online prescription delivery, though, so it may not be the right fit if you want treatment delivered to your door.
Pros:
- Affordable, flat-rate consultation fees for sudden minor health issues
- Direct integration with GoodRx retail discount coupons to potentially lower pharmacy prices
- Prescriptions can be sent to any local pharmacy of your choice for same-day pickup
Cons:
- Does not offer direct-to-door home shipping
- Requires traveling to a local retail pharmacy for pickup
9. Amwell

- Best for: Insurance-covered urgent care and specialty consultations
- Medicines offered: Prescriptions for immediate urgent care needs, behavioral health conditions, and basic chronic diseases
- Pricing: Insurance billing or flat cash-visit fees
Amwell handles sudden illnesses, online therapy, and visits with medical specialists. They offer 24/7 video calls to connect you with doctors, with services widely covered by health insurance plans. If you don’t have eligible health insurance or have high copays or deductibles, paying out of pocket may cost more than with platforms built for self-pay patients.
But if your health plan covers Amwell’s services as a benefit, it may help you access virtual care.
Pros:
- 24/7 on-demand urgent care video visits with certified emergency clinicians
- Seamless integration with major corporate employer benefits and commercial health plans
- Access to an expansive network of digital specialists, including pediatricians and licensed therapists
Cons:
- Cannot prescribe erectile dysfunction medications, muscle relaxants, or insomnia medications
- Less practical and more expensive if you are making a quick, standalone cash purchase out of pocket
- Does not offer direct-to-door home shipping for prescriptions
- Requires traveling to a local retail pharmacy for prescription pickup
How to Choose the Right Telehealth Platform for Your Needs
Choosing a virtual care solution shouldn’t mean trading physical waiting rooms for insurance headaches and mandatory monthly subscriptions. If you want a straightforward, friction-free way to get your prescriptions, here is what to look for before making a final choice:
- Look for transparent, upfront pricing with no hidden fees: Broad telehealth platforms often provide wide medication access, but some include hidden booking costs or lock you into mandatory recurring subscription plans. Look for services that show you the exact total cost before you enter your payment details.
- Match the platform’s specialties to your specific care needs: Some spaces are optimized for chronic primary care, while others focus strictly on specialized areas like men’s health or dermatology. If you have broader needs, look for a platform that offers broader condition coverage.
- Verify credentials and state availability: Telehealth regulations and prescription shipping laws vary by state. Always make sure your digital healthcare platform is legit and works with licensed doctors who meet your state’s requirements to practice in your area.
- Check for prescription fulfillment and discreet home delivery: Consider how you actually want to receive your treatment. If privacy is a high priority, seek out services that mail prescriptions in discreet packaging.
- Consider whether a cash-pay model fits better than insurance: Insurance-based platforms can keep visit costs low if your plan covers them. If you’re uninsured or have a high deductible, a cash-pay platform can be a faster, more affordable option.
- Evaluate the ease of online consultations and ordering: Think about how much time you want to spend securing your refill, or whether you want to schedule a virtual doctor’s appointment.
Affordable, Discreet Care Is a Click Away With TelyRx
Taking care of your health shouldn’t require tracking confusing insurance rules or getting stuck in mandatory monthly subscription plans you never wanted in the first place. At TelyRx, we’re dedicated to keeping the process simple, affordable, and private.
Our focus is entirely on giving you clear-cut pricing for your daily prescriptions — which means no middlemen, no insurance hurdles, and absolutely no mandatory memberships.
Take control of your healthcare routine today.
Frequently Asked Questions
How do telehealth platforms work?
Some telehealth platforms offer virtual visits, where you speak with a provider by video, phone, or message to get a diagnosis and treatment. Others focus on medication requests, where you complete a health questionnaire or attestation, and a provider reviews it.
Visit-based platforms suit people who need a new diagnosis, while request-based platforms like TelyRx suit those who already know which medication they need.
Is it safe to get prescriptions through a telehealth platform?
Yes, as long as you choose a reputable platform. Legitimate services follow HIPAA privacy rules, require a licensed provider to review your health information before prescribing, and fill prescriptions through licensed U.S. pharmacies.
Who are telehealth platforms best for?
Telehealth works well for adults with busy schedules, people managing ongoing conditions, and anyone who wants more privacy for sensitive health concerns. It can also help if you’re uninsured or want predictable out-of-pocket costs.
What is the best telemedicine service without insurance?
If you’re uninsured, look for platforms with upfront cash pricing and no mandatory membership. Pay-per-visit services like Sesame and GoodRx Care work well for one-time diagnoses, while TelyRx offers cash pricing on a wide range of generic medications if you already know what you need.






