Generic for Vagifem®

Estradiol Vaginal Inserts
No prior prescription needed
  • One-time provider review fee per order for new prescriptions
  • No hidden costs, ever
  • Ships same day in plain, discreet packaging
  • If not approved, cost of medication automatically refunded
  • HSA/FSA Eligible
starting at $69.99
In stock

Starting at:

I already have a prescription From $0.00 no provider fee

Transfer a valid Rx and pay the medication price only.
Pharmacy name and phone number required.
Ships within 2-4 days.

I need a new prescription From $0.00 includes $22 provider fee
Recommended, Fastest

A licensed provider reviews immediately and prescribes your Rx online.
Ships same day if ordered by 2PM ET.

I need a prescription I have a prescription
Prescription
No, we handle it
You provide it
Doctor's appointment
Not needed
Arrange on your own
Ready to order
In minutes
When your Rx is received
Licensed provider review
Included
Not included
Medication price $0.00 $0.00
Provider's fee (one-time per order) $22.00 $0.00
Total today $0.00 $0.00
No prescription? No problem. An independent licensed U.S. provider reviews your prescription request, no matter how many medications in an order. Refills that qualify skip the review and the fee entirely.

Subtotal
One-time provider fee $22.00
Shipping Determined by zip code
Total
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Healthcare,
made simple.

No insurance. No doctor's visit.
Just the medicine you need: no waiting, no worries.

Estradiol vaginal tablets provide localized estrogen therapy for people experiencing vulvovaginal symptoms related to menopause or other conditions associated with estrogen deficiency. As estrogen levels decline, vaginal tissues can become thin, dry, and less elastic, leading to symptoms such as irritation, itching, pain with intercourse, and urinary discomfort. When placed in the vagina, estradiol acts directly on estrogen receptors in the local tissue, promoting cell renewal, increasing blood flow, and improving natural lubrication. Because the medication is administered vaginally, systemic absorption is generally low compared to oral or transdermal estrogen therapy. This medication is commonly used as part of a targeted treatment plan for genitourinary syndrome of menopause and is often preferred when symptoms are limited to the vaginal area. It is typically started with a more frequent dosing schedule followed by maintenance dosing as symptoms improve. Patients should be counseled on proper tablet insertion, consistent use, and the expectation that symptom relief may take several weeks. Although systemic exposure is low, patients with a history of estrogen-sensitive cancers, unexplained vaginal bleeding, or blood clots should discuss risks and benefits with their healthcare provider. Regular follow-up is recommended to ensure ongoing need and symptom control.

Testimonials

What patients are saying

4.8 out of 5

3,902 verified reviews on Trustpilot

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TelyRx FAQs

Answers to common questions about treatment, pricing, and how this all works.
Why should I trust TelyRx?

Absolutely. Every order is reviewed by a board-certified provider licensed in all 50 states. We dispense only FDA-approved medications and are fully HIPAA compliant. Real healthcare, real oversight.

Is insurance required?

You don't need it. TelyRx works outside of insurance entirely, so the price you see upfront is the price you pay. No prior authorizations, no claim denials, no waiting on approvals.

What will my medication cost?

Search any medication on our site and see your price instantly—no account required. Provider review is included. Most people pay a fraction of typical pharmacy prices.

Do I need to have a prescription?

Not to get started. Complete a short health questionnaire and a licensed provider will review your request. Already have one? 
You can transfer it to TelyRx directly.

How do I transfer my existing prescription to the TelyRx platform?

Make sure you have created an account with TelyRx if you haven't already done so. Select the “I have a prescription” option when adding your request to your cart. If we don’t have the exact medication (dosage, quantity, formulation) matching your prescription, we recommend that you request a prescription through our platform to reduce any potential delay or denial. Provide your current pharmacy’s name and phone number, as well as your prescription number. Our customer service team will reach out for more information as needed.

If your prescription details differ from the order you submitted, such as if the dosage differs, your order will be cancelled and you will not be charged.

If we do not have your exact match in dosage, quantity, or formulation, we recommend selecting the “I need a prescription” option to avoid potential fulfillment delays. Your request will be reviewed by an independent, licensed provider.

More Information
Sex Female
Pick and Pack Yes
Order Flagging System No
Set Cart Qty Limit 4
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