Generic for Estrace

Estradiol Vaginal Cream
No prior prescription needed
  • One-time provider review fee per order for new prescriptions
  • No hidden costs, ever
  • Ships same day in plain, discreet packaging
  • If not approved, cost of medication automatically refunded
  • HSA/FSA Eligible
starting at $46.99
In stock

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I already have a prescription From $0.00 no provider fee

Transfer a valid Rx and pay the medication price only.
Pharmacy name and phone number required.
Ships within 2-4 days.

I need a new prescription From $0.00 includes $22 provider fee
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A licensed provider reviews immediately and prescribes your Rx online.
Ships same day if ordered by 2PM ET.

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One-time provider fee $22.00
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Medication price $0.00 $0.00
Provider's fee (one-time per order) $22.00 $0.00
Total today $0.00 $0.00
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Estradiol vaginal cream is a low-dose estrogen therapy used to treat moderate to severe vaginal symptoms associated with menopause, such as dryness, burning, and painful intercourse. This formulation is preferred when symptoms are localized to the vaginal area, as it has been shown in studies to provide effective relief with lower systemic absorption and reduced risk of widespread estrogen-related side effects.

The cream is inserted directly into the vagina using a pre-measured applicator and is FDA-approved to treat vulvovaginal atrophy due to menopause. Patients typically use it once daily for the first two weeks of therapy, then reduce to a maintenance dose of one to three applications per week.

 

How To Use:

Use only as directed by a healthcare provider

Insert cream using the included applicator, ideally at bedtime

Recommended for women 60 years or younger or within 10 years of menopause

Each tube contains 42.5 grams of estradiol cream

 

Warnings:

Not recommended for individuals with a history of estrogen-sensitive cancers or undiagnosed vaginal bleeding

Routine check-ins may be necessary to reassess treatment appropriateness

Patients should review personal and family risk factors with their provider before starting therapy

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TelyRx FAQs

Answers to common questions about treatment, pricing, and how this all works.
Why should I trust TelyRx?

Absolutely. Every order is reviewed by a board-certified provider licensed in all 50 states. We dispense only FDA-approved medications and are fully HIPAA compliant. Real healthcare, real oversight.

Is insurance required?

You don't need it. TelyRx works outside of insurance entirely, so the price you see upfront is the price you pay. No prior authorizations, no claim denials, no waiting on approvals.

What will my medication cost?

Search any medication on our site and see your price instantly—no account required. Provider review is included. Most people pay a fraction of typical pharmacy prices.

Do I need to have a prescription?

Not to get started. Complete a short health questionnaire and a licensed provider will review your request. Already have one? 
You can transfer it to TelyRx directly.

How do I transfer my existing prescription to the TelyRx platform?

Make sure you have created an account with TelyRx if you haven't already done so. Select the “I have a prescription” option when adding your request to your cart. If we don’t have the exact medication (dosage, quantity, formulation) matching your prescription, we recommend that you request a prescription through our platform to reduce any potential delay or denial. Provide your current pharmacy’s name and phone number, as well as your prescription number. Our customer service team will reach out for more information as needed.

If your prescription details differ from the order you submitted, such as if the dosage differs, your order will be cancelled and you will not be charged.

If we do not have your exact match in dosage, quantity, or formulation, we recommend selecting the “I need a prescription” option to avoid potential fulfillment delays. Your request will be reviewed by an independent, licensed provider.

More Information
Sex Female
Pick and Pack Yes
Order Flagging System No
Set Cart Qty Limit 4
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