How It Works
Anucort-HC works by calming the immune response in the rectal area. As a corticosteroid, it targets the biological triggers that cause painful swelling and redness. The medication helps lower the production of chemicals that cause blood vessels to enlarge, which provides relief from itching and calms the sensitive nerve endings responsible for pain. This treatment also helps shrink inflamed tissue by narrowing small blood vessels in the area.
Once inserted, the suppository melts so the medicine can be absorbed into the tissue lining where the irritation is located.
| Quick Facts | |
|---|---|
| Common Brands | Anucort-HC, Anusol-HC, Hemmorex-HC |
| Drug Class | Corticosteroid |
| Generic Status | Generic version available (hydrocortisone acetate) |
| Availability | Prescription only |
Dosing
Anucort-HC is a suppository, so it is for rectal use only and should never be taken by mouth. For the best results, it is often recommended to use the medication after a bowel movement.
The immediate-release rectal suppositories are available in the following doses:
- 25 mg
- 30 mg
The frequency and timing of your dose will depend on the specific condition being managed.
- Standard adult dosage: The typical starting dose is one 25 mg suppository inserted twice daily, once in the morning and once at night.
- Maximum dosage: In some cases, a provider may increase the frequency to one suppository three times a day or two suppositories twice daily.
- Missed doses: If you miss a dose, use it as soon as you remember, unless it is almost time for the next one. Do not double the dose.
Note: Dosing information below is educational only. Your prescribing physician will determine your specific dose based on your individual health needs. Always follow your healthcare provider’s instructions for exact dosing.
Uses
FDA-Approved Uses
Anucort-HC is FDA-approved for treating inflamed hemorrhoids and post-irradiation (factitial) proctitis.
Off-Label Uses
You may see Anucort-HC prescribed for uses that are not “FDA-approved.” This is a very common and legal practice called “off-label” prescribing, where a doctor uses their clinical judgment to prescribe a drug for a different (but well-researched) purpose.
Providers may prescribe Anucort-HC off-label as an adjunct therapy for chronic ulcerative colitis, cryptitis, and other inflammatory conditions of the anorectum. Additionally, it is sometimes used to manage symptoms of anal fissures or persistent anal itching that has not responded to other treatments.
Side Effects
It is common for the body to go through a bit of an adjustment period when you first start using Anucort-HC. You might notice some mild side effects as your system gets used to the medication, though many of these typically fade on their own over time.
Though less common, serious side effects are also possible and require medical attention.
Common Side Effects
- Rectal burning or stinging
- Itching or irritation at the application site
- Dryness of the rectal tissues
- Small, red, or pus-filled bumps around hair follicles
- Lightening of skin color in the treated area
Serious Side Effects
Serious side effects are rare, but it’s important to know what to look for if they do occur. Call your doctor immediately if you experience:
- Severe allergic reactions: Symptoms such as hives, swelling of the face or throat, or difficulty breathing.
- Adrenal suppression: This can occur with long-term use and may cause extreme fatigue, weight loss, or muscle weakness.
- Increased blood pressure: Steroids can sometimes cause a noticeable rise in blood pressure.
- Rectal infection: Signs include increased pain, swelling, warmth, or pus discharge from the area.
- Thinning skin: Prolonged use may lead to fragile skin that bruises or tears easily.
- Vision changes: Rarely, systemic absorption can contribute to increased eye pressure or cataracts.
Call your doctor immediately if you experience any concerning or prolonged symptoms.
Pharmacist Tips
Wash Your Hands
Ensure hands are clean before and after insertion to prevent the medication from accidentally touching your eyes.
Avoid Staining
These suppositories can leak slightly as they melt; consider using a panty liner or disposable underwear to protect your clothing.
Stay Recumbent
Try to stay lying down for at least 15 minutes after insertion so the medication stays in contact with the inflamed area.
Check Consistency
If the suppository feels too soft to insert, keep it in the foil and run it under cold tap water until it firms up.
Bowel Movements
Try to use the restroom before inserting the medication, as having a bowel movement shortly after insertion can wash the medicine away.
Do Not Stop Abruptly
If you have used this medication for a long period, talk to your doctor before stopping to avoid potential withdrawal symptoms.
Drug Interactions
While Anucort-HC is designed for localized relief with minimal absorption into the bloodstream, it can still interact with other rectal treatments or medications that affect your body’s steroid levels. For example:
- Other rectal products: Avoid using other creams, ointments, or enemas at the same time unless directed by your doctor.
- Oral steroids: Using Anucort-HC alongside oral corticosteroids can increase the risk of systemic side effects.
- NSAIDS or blood thinners: If you have active rectal bleeding, using aspirin or warfarin may complicate your condition.
- Diabetes medications: In rare cases of high absorption, steroids can slightly influence blood sugar levels.
Always give your doctor and pharmacist a complete list of all your medications, vitamins, and supplements to check for potential interactions.
FAQs
How long does it usually take for Anucort-HC to start relieving symptoms?
Most patients notice a reduction in itching and swelling within a few days, though it may take a full week for significant improvement.
Do I need to keep these suppositories in the refrigerator?
Standard guidelines suggest room temperature storage. However, if your home is warm and they soften, you may briefly refrigerate them to make insertion easier.
What is the main difference between prescription Anucort-HC and over-the-counter options like Preparation H?
OTC Preparation H usually contains protectants. Anucort-HC is a much stronger corticosteroid designed to treat more severe inflammation.
Is it safe to use this suppository if there is active bleeding?
While hydrocortisone can help shrink bleeding hemorrhoids, you should consult your provider if you notice new or heavy rectal bleeding.
How many consecutive days can I safely use Anucort-HC?
Providers typically recommend short-term use, often 7 to 14 days. Prolonged use should only be done under medical supervision.
Is a mild burning or stinging sensation normal after insertion?
Yes, a brief sensation of stinging or warmth is a common side effect as the suppository begins to melt.
What should I do if the suppository softens inside the wrapper before I can use it?
Keep it in the foil and hold it under cold running water or place it in the freezer for a few minutes until it becomes firm.
How long should I wait to use the restroom after inserting Anucort-HC?
Standard guidelines suggest trying to avoid a bowel movement for at least one to three hours after insertion.
Can I use Anucort-HC along with an over-the-counter lidocaine numbing cream?
Ask your provider first. If approved, it is generally recommended to apply cream externally and use the suppository for internal relief.
Does the steroid in this medication absorb into the rest of my body?
Only a very small amount is typically absorbed. However, with long-term use or high doses, systemic absorption can increase.
Can this be used for an anal fissure, or is it strictly for internal hemorrhoids?
While FDA-approved for hemorrhoids, doctors sometimes prescribe it off-label for fissures to reduce inflammation that prevents healing.
Is it better to use Anucort-HC in the morning or right before bed?
If prescribed twice daily, it is best used once in the morning and once at bedtime to allow the medicine to remain in place.
Should I avoid fiber supplements while using this treatment?
Generally, no. Providers often recommend fiber supplements and increased water intake to soften stools and prevent further irritation. Talk to your provider to identify what is best in your situation.
Is Anucort-HC safe to use during pregnancy or postpartum?
Consult your OB-GYN before use. Anucort-HC is only recommended during pregnancy if clearly needed to avoid effects on the fetus.
Does Anucort-HC shrink the tissue permanently or manage a current flare-up?
It manages active flare-ups by reducing inflammation. It does not cure the underlying tendency for hemorrhoids.
Comparable Medications
Phenylephrine, Lidocaine-Hydrocortisone, or Hydrocortisone Acetate Foam?
Phenylephrine
Found in many OTC products, this is a vasoconstrictor that temporarily shrinks swollen tissue but does not have powerful anti-inflammatory properties.
Lidocaine-Hydrocortisone Cream
From $59.99
This combination provides the anti-inflammatory benefits of hydrocortisone along with lidocaine, a local anesthetic for numbing pain.
Hydrocortisone acetate foam
While containing the same active ingredient, the foam is often used for conditions slightly higher up in the rectum, as it can be easier to distribute.
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Important: Information on this page is for educational purposes only. Prescribing decisions are made by independent, licensed providers. TelyRx operates technology-enabled pharmacies and a telehealth platform that connects patients with licensed providers. Prescriptions, when provider-approved and issued, are filled and shipped by TelyRx-affiliated pharmacies. We do not employ physicians or make prescribing decisions. Learn more about our editorial standards here.