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Neffy is a nasal spray used for emergency treatment of allergic reactions including anaphylaxis. Anaphylaxis can be life-threatening, can happen in minutes, and can be caused by stinging and biting insects, allergy injections, foods, medicines, exercise, or other unknown causes. As the first FDA-approved needle-free option for this indication, Neffy uses Intravail technology, which temporarily loosens the spaces between the nasal cells to help epinephrine be absorbed into the body, allowing the medication to be rapidly absorbed into the nasal passage to reverse the reaction. Pharmacologically, it functions as a non-selective adrenergic receptor agonist, meaning it acts on the same receptors targeted by injectable epinephrine, producing comparable effects on blood pressure and heart rate.
In practice, Neffy fits into an anaphylaxis action plan the same way an auto-injector would: patients are instructed to use neffy right away, as soon as they notice symptoms of an allergic reaction, and to always carry two nasal sprays because they may not know when anaphylaxis may happen and may need a second dose if symptoms continue or come back. Each dose should be given as one spray into one nostril, and if symptoms get worse or come back, a second dose is given in the same nostril starting five minutes after the first. Important counseling points include telling the prescriber about any nasal structural issues, since these could affect drug absorption, and disclosing use of other nasal sprays, water pills, or medications for depression, irregular heartbeat, Parkinson's disease, heart disease, thyroid disease, or labor, as these may interact with Neffy. Patients should also understand that Neffy is not a substitute for follow-up emergency care; after use, they still need medical evaluation, since anaphylaxis symptoms can recur.
Common side effects of Neffy include nasal discomfort, congestion, runny nose, sneezing, nosebleeds, nose pain, throat irritation, a tingling or numb sensation in the nose, dry nose or throat, headache, dizziness, fatigue, nausea, vomiting, tremor, and feelings of jitteriness, nervousness, or anxiety, most of which are mild and related either to the nasal delivery method or to epinephrine's stimulant effects on the body. Because Neffy contains the same active ingredient as injectable epinephrine, it carries similar safety warnings, including the potential to raise blood pressure and heart rate, which may be a particular concern for people with heart disease, high blood pressure, thyroid disorders, Parkinson's disease, diabetes, kidney problems, or low blood potassium; however, patients with these conditions should still use Neffy to treat anaphylaxis if prescribed, since untreated anaphylaxis is more dangerous than the medication's risks. Patients should seek follow-up medical care immediately after using Neffy, watch for symptoms that persist or return, and report any side effect that is bothersome or does not go away to their healthcare provider.
This information should not be used to decide whether or not to take this medicine or any other medicine. Only a healthcare provider has the knowledge and training to decide which medicines are right for you. TelyRx does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a limited summary of general information about the medicine’s uses from the patient education materials and is not intended to be comprehensive. This limited summary does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not intended to provide medical advice, diagnosis or treatment and does not replace information you may receive from your healthcare provider. For a more detailed summary of information about the risks and benefits of using this medicine, please review the entire patient education information you receive with the medication.
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