Hydrocortisone cream used for hemorrhoids may cause side effects such as mild skin irritation, burning, or itching at the application site. With prolonged use or overuse, it can lead to thinning of the skin, changes in skin color, or stretch marks. Rarely, systemic absorption may occur, potentially leading to hormonal effects such as increased blood sugar, suppression of adrenal gland function, or delayed wound healing. In some cases, allergic reactions like rash, swelling, or severe irritation may develop. To minimize side effects, it should be used only as directed and not applied to broken skin or used for extended periods without medical supervision.