Halobetasol cream may cause side effects, including burning, stinging, or itching at the application site. Some users experience dryness, redness, or peeling of the skin, especially with prolonged use. Skin thinning and stretch marks can occur if the cream is used over large areas or for extended periods. There is an increased risk of skin infections since halobetasol suppresses the immune response. Discoloration of the treated skin and small red or purple spots (petechiae) may also develop. Acne-like breakouts or worsening of existing acne are possible side effects. Some users notice unwanted hair growth in the treated area. Rash, irritation, or allergic reactions may occur, leading to discomfort. Folliculitis, or inflammation of hair follicles, can develop due to prolonged use. Halobetasol may also slow wound healing, making cuts and scrapes take longer to recover. Increased sensitivity to sunlight is another potential issue, making sun protection important. In rare cases, the medication can be absorbed into the bloodstream, leading to systemic effects like weight gain, fatigue, or hormonal imbalances. Prolonged use over large areas may cause adrenal suppression, which affects hormone production. Misusing halobetasol or using it on the wrong skin conditions can worsen symptoms. To minimize risks, patients should follow their healthcare provider’s instructions carefully and report any severe or persistent side effects.