Contrave is a non-stimulant prescription medication used for weight management in adults who are obese or overweight and have at least one weight-related condition, such as high blood pressure, type 2 diabetes, or high cholesterol. It combines two active ingredients, naltrexone and bupropion, which work together to regulate appetite and reduce cravings. Naltrexone is an opioid antagonist, while bupropion is an antidepressant that affects the brain's reward system. By influencing these pathways, Contrave helps support long-term weight loss when combined with a healthy diet and exercise. It is important to avoid using opiates for a specified period before starting naltrexone, depending on the type of opioid used. While naltrexone and bupropion are used separately for other conditions, this combination product is only FDA approved for weight management.
- Contrave is a combination product that contains bupropion (an antidepressant) and naltrexone (an opioid antagonist) to support weight loss with exercise and a healthy diet
- Contrave was first approved by the FDA in 2014 for weight loss
- Contrave works by two mechanisms: naltrexone helps to curb cravings while bupropion boosts metabolism and suppresses appetite
- Contrave is typically taken as two pills twice a day, gradually increasing to this dosage over time to minimize side effects
- By aiding in weight loss, Contrave can indirectly reduce the risks associated with obesity, including heart disease, stroke, and type 2 diabetes
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Contrave® Side Effects
Contrave side effects may include: nausea, vomiting, constipation, headache, dizziness, dry mouth, insomnia, diarrhea, anxiety, increased blood pressure, or an elevated heart rate.
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