{"id":8972,"date":"2026-06-02T14:37:23","date_gmt":"2026-06-02T14:37:23","guid":{"rendered":"https:\/\/telyrx.com\/blog\/?p=8972"},"modified":"2026-06-02T14:37:36","modified_gmt":"2026-06-02T14:37:36","slug":"what-is-nexgard","status":"publish","type":"post","link":"https:\/\/telyrx.com\/blog\/medications\/what-is-nexgard\/","title":{"rendered":"What Is NexGard?"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\" id=\"h-how-it-works\">How It Works<\/h2>\n\n\n\n<p>The active ingredient in NexGard is afoxolaner, which belongs to a class of drugs called isoxazoline ectoparasiticides. After a dog eats the chewable NexGard tablet, the medication is absorbed into their bloodstream. When fleas and ticks bite the dog and ingest the treated blood, afoxolaner kills the parasites by disrupting their central nervous system.<\/p>\n\n\n\n<div class=\"quick-facts-card\">\n  <table class=\"quick-facts-table\">\n    <colgroup>\n      <col\/>\n      <col\/>\n    <\/colgroup>\n\n    <thead>\n      <tr>\n        <th colspan=\"2\">Quick Facts<\/th>\n      <\/tr>\n    <\/thead>\n\n    <tbody>\n      <tr>\n        <td><strong>Common Brands<\/strong><\/td>\n        <td>NexGard, NexGard Plus<\/td>\n      <\/tr>\n\n      <tr>\n         <td><strong>Drug Class<\/strong><\/td>\n        <td>Isoxazoline ectoparasiticide<\/td>\n      <\/tr>\n\n      <tr>\n        <td><strong>Generic Status<\/strong><\/td>\n        <td>Not available as a generic<\/td>\n      <\/tr>\n\n      <tr>\n         <td><strong>Availability<\/strong><\/td>\n        <td>Prescription only<\/td>\n    <\/tbody>\n  <\/table>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-dosing\">Dosing<\/h2>\n\n\n\n<p>NexGard is administered orally once a month. The standard recommended minimum dosage is 1.14 mg per pound (2.5 mg\/kg). The chewables are available in different sizes depending on a dog\u2019s weight.&nbsp;<\/p>\n\n\n\n<p>NexGard can be given to dogs with or without food. It is generally accepted that treatment can begin at any time of the year and should continue monthly without interruption, especially in areas where fleas are common year-round.<\/p>\n\n\n\n<p><em><strong>Note:<\/strong> Dosing information below is educational only. The prescribing veterinarian can suggest a specific dose for your dog.\u00a0Always follow your veterinarian\u2019s instructions for exact dosing.<\/em><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-uses\">Uses<\/h2>\n\n\n\n<p><strong>FDA-Approved Uses<\/strong><\/p>\n\n\n\n<p>NexGard is approved by the FDA for dogs for the treatment and prevention of fleas. It is also approved for dogs for the treatment and control of various species of ticks, including black-legged ticks that are associated with Lyme disease.<\/p>\n\n\n\n<p><strong>Off-Label Uses<\/strong><\/p>\n\n\n\n<p>You may see NexGard prescribed for uses that are not &#8220;FDA-approved.&#8221; This is a common and legal practice called &#8220;off-label&#8221; prescribing, where a veterinarian uses their clinical judgment to prescribe a drug for a different (but well-researched) purpose.<\/p>\n\n\n\n<p>Some examples of common off-label uses of NexGard in dogs include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Treatment of certain types of mange<\/li>\n\n\n\n<li>Treatment of ear mite infestations<\/li>\n\n\n\n<li>Control of bedbugs and sand flies<\/li>\n<\/ul>\n\n\n<div class=\"telyrx-email-cta telyrx-email-cta--banner alignfull wp-block-telyrx-email-signup\">\n\t\t<h2 class=\"telyrx-email-cta__heading\" data-toc-hidden=\"true\">Get Savings Updates<\/h2>\n\t<p class=\"telyrx-email-cta__description\">Join our mailing list for exclusive deals and more.<\/p>\n\t\t\t<form\n\t\t\tid=\"telyrx-email-form-1\"\n\t\t\tclass=\"telyrx-email-cta__form\"\n\t\t\tdata-portal-id=\"46401311\"\n\t\t\tdata-form-id=\"14e1d7d5-6b17-4228-b42e-c06d1a6c240b\"\n\t\t\tdata-i18n=\"{&quot;subscribe&quot;:&quot;Subscribe&quot;,&quot;success&quot;:&quot;Thanks! You&#039;re subscribed.&quot;,&quot;error&quot;:&quot;Something went wrong. Please try again.&quot;}\"\n\t\t>\n\t\t\t<div class=\"telyrx-email-cta__pill\">\n\t\t\t\t<input\n\t\t\t\t\ttype=\"email\"\n\t\t\t\t\tname=\"email\"\n\t\t\t\t\tclass=\"telyrx-email-cta__input\"\n\t\t\t\t\tplaceholder=\"Enter your email\"\n\t\t\t\t\trequired\n\t\t\t\t\tautocomplete=\"email\"\n\t\t\t\t\/>\n\t\t\t\t<button type=\"submit\" class=\"telyrx-email-cta__button\">\n\t\t\t\t\tSubscribe\t\t\t\t<\/button>\n\t\t\t<\/div>\n\t\t\t<p class=\"telyrx-email-cta__status\" aria-live=\"polite\"><\/p>\n\t\t<\/form>\n\t\t<noscript>\n\t\t\t<p class=\"telyrx-email-cta__noscript\">Please enable JavaScript to use the signup form.<\/p>\n\t\t<\/noscript>\n\t<\/div>\n\n\n\n<section class=\"telyrx-side-effects\" data-toc-title=\"Side Effects\">\n\t<h2 class=\"telyrx-side-effects__heading\">Side Effects<\/h2>\n\t<hr class=\"telyrx-side-effects__separator\">\n\t<div class=\"telyrx-side-effects__content\">\n\t\t\n\n<p>Like all medications, NexGard can cause side effects. Some side effects may be serious and require veterinary attention.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-common-side-effects\">Common Side Effects<\/h3>\n\n\n\n<div class=\"telyrx-side-effects-chip telyrx-side-effects-chip--common\">\n\t\n\n<ul class=\"wp-block-list\">\n<li>Vomiting<\/li>\n\n\n\n<li>Diarrhea<\/li>\n\n\n\n<li>Lethargy<\/li>\n\n\n\n<li>Decreased appetite<\/li>\n\n\n\n<li>Itching<\/li>\n<\/ul>\n\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-serious-side-effects\">Serious Side Effects<\/h3>\n\n\n\n<div class=\"telyrx-side-effects-chip telyrx-side-effects-chip--serious\">\n\t\n\n<p>Serious side effects are rare, but it&#8217;s important to know what to look for if they do occur.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Muscle tremors:<\/strong> Neurologic issues such as involuntary muscle shaking have been associated with medications like NexGard.<\/li>\n\n\n\n<li><strong>Ataxia:<\/strong> Some dogs may experience difficulty walking or a loss of coordination after taking NexGard.<\/li>\n\n\n\n<li><strong>Seizures:<\/strong> Seizures have been reported in some dogs receiving drugs like NexGard, including some dogs with no prior history of seizures.<\/li>\n\n\n\n<li><strong>Excessive vomiting:<\/strong> While mild vomiting is considered a common side effect of NexGard, continuous or severe vomiting is a serious reaction that requires veterinary attention.<\/li>\n<\/ul>\n\n<\/div>\n\n\n\n<p class=\"has-muted-color has-text-color\" style=\"font-size:0.875rem\"><em>Call your dog\u2019s veterinarian immediately if your dog experiences any concerning or prolonged symptoms after taking NexGard.<\/em><\/p>\n\n\t<\/div>\n<\/section>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-pharmacist-tips\">Pharmacist Tips<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-monitor-consumption\">Monitor Consumption<\/h3>\n\n\n\n<p>Care should be taken to ensure your dog consumes the entire chewable tablet. Veterinarians advise observing your dog for a few minutes afterward to make sure no part of the tablet is refused or leaves their mouth.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-administer-with-food-if-needed\">Administer With Food If Needed<\/h3>\n\n\n\n<p>If your dog tends to throw up or appear sick after taking NexGard on an empty stomach, standard guidelines suggest giving the next dose with food or a small treat.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-redose-after-vomiting\">Redose After Vomiting<\/h3>\n\n\n\n<p>If your dog vomits within two hours of taking NexGard, it is generally recommended to redose with another full chewable.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-maintain-year-round-protection\">Maintain Year-Round Protection<\/h3>\n\n\n\n<p>Fleas can survive indoors after coming inside on people, so continuing NexGard treatment throughout the year is commonly suggested, even for indoor dogs.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-store-properly\">Store Properly<\/h3>\n\n\n\n<p>Keep the medication in its original packaging at room temperature, ideally at or below 86\u00b0F (30\u00b0C), and protect the chews from light.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-wash-your-hands\">Wash Your Hands<\/h3>\n\n\n\n<p>It is good practice to wash your hands with soap and water after handling the chewable tablets.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-drug-interactions\">Drug Interactions<\/h2>\n\n\n\n<p>No major drug interactions are well documented with NexGard. In clinical studies, NexGard was used safely with many common veterinary medications, including vaccines, antibiotics, corticosteroids, NSAIDs, anesthetics, and antihistamines. Dogs with a history of seizures or neurologic disorders may have a higher risk of neurologic side effects with NexGard and should be monitored closely.&nbsp;<\/p>\n\n\n\n<p>Always give your dog\u2019s veterinarian a complete list of their medications, vitamins, and supplements to check for potential interactions.<\/p>\n\n\n\n<section class=\"telyrx-faq-section\" data-toc-title=\"FAQs\">\n\t<h2 class=\"telyrx-faq-heading\">FAQs<\/h2>\n\t\t<div class=\"telyrx-faq-items\">\n\t\t\n\n<details class=\"telyrx-faq-item\">\n\t<summary class=\"telyrx-faq-question\">\n\t\t<span class=\"telyrx-faq-question-text\">How long does it actually take for NexGard to start killing fleas after my dog eats the chew?<\/span>\n\t\t<svg class=\"telyrx-faq-chevron\" width=\"20\" height=\"20\" viewBox=\"0 0 20 20\" fill=\"none\" aria-hidden=\"true\">\n\t\t\t<path d=\"M5 7.5L10 12.5L15 7.5\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n\t\t<\/svg>\n\t<\/summary>\n\t<div class=\"telyrx-faq-answer\">\n\t\t\n\n<p>NexGard begins to kill fleas within 4 hours of administration. It is demonstrated to be over 99% effective at killing fleas within 8 hours.<\/p>\n\n\t<\/div>\n<\/details>\n\n\n\n<details class=\"telyrx-faq-item\">\n\t<summary class=\"telyrx-faq-question\">\n\t\t<span class=\"telyrx-faq-question-text\">Does this medication repel fleas and ticks, or do they have to bite my dog first?<\/span>\n\t\t<svg class=\"telyrx-faq-chevron\" width=\"20\" height=\"20\" viewBox=\"0 0 20 20\" fill=\"none\" aria-hidden=\"true\">\n\t\t\t<path d=\"M5 7.5L10 12.5L15 7.5\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n\t\t<\/svg>\n\t<\/summary>\n\t<div class=\"telyrx-faq-answer\">\n\t\t\n\n<p>Parasites must bite your dog to be exposed to the medication in NexGard. The active ingredient is absorbed into your dog&#8217;s bloodstream, so the fleas and ticks have to ingest blood from your dog in order for NexGard to kill them.<\/p>\n\n\t<\/div>\n<\/details>\n\n\n\n<details class=\"telyrx-faq-item\">\n\t<summary class=\"telyrx-faq-question\">\n\t\t<span class=\"telyrx-faq-question-text\">What is the difference between standard NexGard and the newer NexGard PLUS?<\/span>\n\t\t<svg class=\"telyrx-faq-chevron\" width=\"20\" height=\"20\" viewBox=\"0 0 20 20\" fill=\"none\" aria-hidden=\"true\">\n\t\t\t<path d=\"M5 7.5L10 12.5L15 7.5\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n\t\t<\/svg>\n\t<\/summary>\n\t<div class=\"telyrx-faq-answer\">\n\t\t\n\n<p>Standard NexGard contains only afoxolaner and is intended to control fleas and ticks. NexGard PLUS contains afoxolaner alongside moxidectin and pyrantel. The addition of these other medications is designed to also prevent heartworm disease and treat intestinal roundworms and hookworms.<\/p>\n\n\t<\/div>\n<\/details>\n\n\n\n<details class=\"telyrx-faq-item\">\n\t<summary class=\"telyrx-faq-question\">\n\t\t<span class=\"telyrx-faq-question-text\">What should I do if my dog throws up the chew within an hour of eating it?<\/span>\n\t\t<svg class=\"telyrx-faq-chevron\" width=\"20\" height=\"20\" viewBox=\"0 0 20 20\" fill=\"none\" aria-hidden=\"true\">\n\t\t\t<path d=\"M5 7.5L10 12.5L15 7.5\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n\t\t<\/svg>\n\t<\/summary>\n\t<div class=\"telyrx-faq-answer\">\n\t\t\n\n<p>Standard guidelines indicate that if your dog vomits any portion of the chewable tablet within two hours of receiving it, you should report the event to your veterinarian and administer a new, full dose.<\/p>\n\n\t<\/div>\n<\/details>\n\n\n\n<details class=\"telyrx-faq-item\">\n\t<summary class=\"telyrx-faq-question\">\n\t\t<span class=\"telyrx-faq-question-text\">Can I safely divide the chewable tablet if I have two smaller dogs?<\/span>\n\t\t<svg class=\"telyrx-faq-chevron\" width=\"20\" height=\"20\" viewBox=\"0 0 20 20\" fill=\"none\" aria-hidden=\"true\">\n\t\t\t<path d=\"M5 7.5L10 12.5L15 7.5\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n\t\t<\/svg>\n\t<\/summary>\n\t<div class=\"telyrx-faq-answer\">\n\t\t\n\n<p>Instructions indicate that you should not divide NexGard tablets. For effective treatment, care must be taken to ensure the dog consumes the complete, accurately dosed tablet for their specific weight range.<\/p>\n\n\t<\/div>\n<\/details>\n\n\n\n<details class=\"telyrx-faq-item\">\n\t<summary class=\"telyrx-faq-question\">\n\t\t<span class=\"telyrx-faq-question-text\">Does standard NexGard protect my dog against heartworms or intestinal tapeworms?<\/span>\n\t\t<svg class=\"telyrx-faq-chevron\" width=\"20\" height=\"20\" viewBox=\"0 0 20 20\" fill=\"none\" aria-hidden=\"true\">\n\t\t\t<path d=\"M5 7.5L10 12.5L15 7.5\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n\t\t<\/svg>\n\t<\/summary>\n\t<div class=\"telyrx-faq-answer\">\n\t\t\n\n<p>No, the standard version of NexGard only targets fleas and ticks. To protect against heartworms or other intestinal parasites, a different product like NexGard PLUS or a separate medication would be required. Consult your veterinarian about the most appropriate medication for your dog.<\/p>\n\n\t<\/div>\n<\/details>\n\n\n\n<details class=\"telyrx-faq-item\">\n\t<summary class=\"telyrx-faq-question\">\n\t\t<span class=\"telyrx-faq-question-text\">Is it safe to give my dog their monthly heartworm pill on the same day?<\/span>\n\t\t<svg class=\"telyrx-faq-chevron\" width=\"20\" height=\"20\" viewBox=\"0 0 20 20\" fill=\"none\" aria-hidden=\"true\">\n\t\t\t<path d=\"M5 7.5L10 12.5L15 7.5\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n\t\t<\/svg>\n\t<\/summary>\n\t<div class=\"telyrx-faq-answer\">\n\t\t\n\n<p>Research studies have shown that NexGard can be safely used with many other medications, including anthelmintics (dewormers) and vaccines. However, safety depends on the specific drugs and dosages being given. As a result, you should always check with your veterinarian before giving more than one medication to your dog.<\/p>\n\n\t<\/div>\n<\/details>\n\n\n\n<details class=\"telyrx-faq-item\">\n\t<summary class=\"telyrx-faq-question\">\n\t\t<span class=\"telyrx-faq-question-text\">Can I safely give this dog medication to my cat if I adjust the dosage for their weight?<\/span>\n\t\t<svg class=\"telyrx-faq-chevron\" width=\"20\" height=\"20\" viewBox=\"0 0 20 20\" fill=\"none\" aria-hidden=\"true\">\n\t\t\t<path d=\"M5 7.5L10 12.5L15 7.5\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n\t\t<\/svg>\n\t<\/summary>\n\t<div class=\"telyrx-faq-answer\">\n\t\t\n\n<p>No, NexGard is for use in dogs only and should never be given to cats. There is a separate topical product designed for cats called NexGard Combo.<\/p>\n\n\t<\/div>\n<\/details>\n\n\n\n<details class=\"telyrx-faq-item\">\n\t<summary class=\"telyrx-faq-question\">\n\t\t<span class=\"telyrx-faq-question-text\">Can this chew be used off-label by my vet to clear up a mange infection?<\/span>\n\t\t<svg class=\"telyrx-faq-chevron\" width=\"20\" height=\"20\" viewBox=\"0 0 20 20\" fill=\"none\" aria-hidden=\"true\">\n\t\t\t<path d=\"M5 7.5L10 12.5L15 7.5\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n\t\t<\/svg>\n\t<\/summary>\n\t<div class=\"telyrx-faq-answer\">\n\t\t\n\n<p>NexGard may be prescribed off-label to treat certain types of mange and skin mites in dogs. However, using NexGard in this way requires careful monitoring by your veterinarian.<\/p>\n\n\t<\/div>\n<\/details>\n\n\n\n<details class=\"telyrx-faq-item\">\n\t<summary class=\"telyrx-faq-question\">\n\t\t<span class=\"telyrx-faq-question-text\">Why do I need a prescription from a vet to buy this?<\/span>\n\t\t<svg class=\"telyrx-faq-chevron\" width=\"20\" height=\"20\" viewBox=\"0 0 20 20\" fill=\"none\" aria-hidden=\"true\">\n\t\t\t<path d=\"M5 7.5L10 12.5L15 7.5\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n\t\t<\/svg>\n\t<\/summary>\n\t<div class=\"telyrx-faq-answer\">\n\t\t\n\n<p>Because NexGard contains active pharmaceutical ingredients that can cause side effects, the FDA requires it to be dispensed under the supervision and prescription of a licensed veterinarian.<\/p>\n\n\t<\/div>\n<\/details>\n\n\n\n<details class=\"telyrx-faq-item\">\n\t<summary class=\"telyrx-faq-question\">\n\t\t<span class=\"telyrx-faq-question-text\">How should I store a 6-month supply to keep the chews fresh?<\/span>\n\t\t<svg class=\"telyrx-faq-chevron\" width=\"20\" height=\"20\" viewBox=\"0 0 20 20\" fill=\"none\" aria-hidden=\"true\">\n\t\t\t<path d=\"M5 7.5L10 12.5L15 7.5\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n\t\t<\/svg>\n\t<\/summary>\n\t<div class=\"telyrx-faq-answer\">\n\t\t\n\n<p>You should store NexGard chews in their original packaging at room temperature (at or below 86\u00b0F or 30\u00b0C) and protect them from direct light.<\/p>\n\n\t<\/div>\n<\/details>\n\n\t<\/div>\n<\/section>\n<script type=\"application\/ld+json\">{\"@context\":\"https:\/\/schema.org\",\"@type\":\"FAQPage\",\"mainEntity\":[{\"@type\":\"Question\",\"name\":\"How long does it actually take for NexGard to start killing fleas after my dog eats the chew?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"NexGard begins to kill fleas within 4 hours of administration. It is demonstrated to be over 99% effective at killing fleas within 8 hours.\"}},{\"@type\":\"Question\",\"name\":\"Does this medication repel fleas and ticks, or do they have to bite my dog first?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Parasites must bite your dog to be exposed to the medication in NexGard. The active ingredient is absorbed into your dog's bloodstream, so the fleas and ticks have to ingest blood from your dog in order for NexGard to kill them.\"}},{\"@type\":\"Question\",\"name\":\"What is the difference between standard NexGard and the newer NexGard PLUS?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Standard NexGard contains only afoxolaner and is intended to control fleas and ticks. NexGard PLUS contains afoxolaner alongside moxidectin and pyrantel. 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For effective treatment, care must be taken to ensure the dog consumes the complete, accurately dosed tablet for their specific weight range.\"}},{\"@type\":\"Question\",\"name\":\"Does standard NexGard protect my dog against heartworms or intestinal tapeworms?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"No, the standard version of NexGard only targets fleas and ticks. To protect against heartworms or other intestinal parasites, a different product like NexGard PLUS or a separate medication would be required. Consult your veterinarian about the most appropriate medication for your dog.\"}},{\"@type\":\"Question\",\"name\":\"Is it safe to give my dog their monthly heartworm pill on the same day?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Research studies have shown that NexGard can be safely used with many other medications, including anthelmintics (dewormers) and vaccines. However, safety depends on the specific drugs and dosages being given. As a result, you should always check with your veterinarian before giving more than one medication to your dog.\"}},{\"@type\":\"Question\",\"name\":\"Can I safely give this dog medication to my cat if I adjust the dosage for their weight?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"No, NexGard is for use in dogs only and should never be given to cats. There is a separate topical product designed for cats called NexGard Combo.\"}},{\"@type\":\"Question\",\"name\":\"Can this chew be used off-label by my vet to clear up a mange infection?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"NexGard may be prescribed off-label to treat certain types of mange and skin mites in dogs. However, using NexGard in this way requires careful monitoring by your veterinarian.\"}},{\"@type\":\"Question\",\"name\":\"Why do I need a prescription from a vet to buy this?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Because NexGard contains active pharmaceutical ingredients that can cause side effects, the FDA requires it to be dispensed under the supervision and prescription of a licensed veterinarian.\"}},{\"@type\":\"Question\",\"name\":\"How should I store a 6-month supply to keep the chews fresh?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"You should store NexGard chews in their original packaging at room temperature (at or below 86\u00b0F or 30\u00b0C) and protect them from direct light.\"}}]}<\/script>\n\n<div class=\"telyrx-comparable-medications wp-block-telyrx-comparable-medications\">\n\t<h2 class=\"telyrx-comparable-medications__title\">Comparable Medications<\/h2>\n\t\t\t<div class=\"telyrx-comparable-medications__intro\">\n\n<p><strong>NexGard, NexGard PLUS (Afoxolaner\/Moxidectin\/Pyrantel), Simparica (Sarolaner), Heartgard Plus (Ivermectin\/Pyrantel), Frontline Plus (Fipronil)?<\/strong><\/p>\n\n<\/div>\n\t\t\t\t<div class=\"telyrx-comparable-medications__item\">\n\t\t\t<div class=\"telyrx-comparable-medications__item-top\">\n\t\t\t\t<div class=\"telyrx-comparable-medications__item-info\">\n\t\t\t\t\t<h3 class=\"telyrx-comparable-medications__name\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"telyrx-comparable-medications__name-link\" href=\"https:\/\/telyrx.com\/pet-medications\/nexgard-plus\">\n\t\t\t\t\t\t\t\tNexGard Plus Chewable Tablets\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/h3>\n\n\t\t\t\t\t\t\t\t\t\t\t<p class=\"telyrx-comparable-medications__price\">\n\t\t\t\t\t\t\tFrom $45.99\t\t\t\t\t\t<\/p>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<a class=\"telyrx-comparable-medications__cta\" href=\"https:\/\/telyrx.com\/pet-medications\/nexgard-plus\">\n\t\t\t\t\t\tView Product\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<p class=\"telyrx-comparable-medications__description\">\n\t\t\t\t\tNexGard PLUS expands upon the standard NexGard chew by adding ingredients to prevent heartworm disease and treat intestinal hookworms and roundworms.\t\t\t\t<\/p>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<hr class=\"telyrx-comparable-medications__divider\">\n\t\t\t\t\t<div class=\"telyrx-comparable-medications__item\">\n\t\t\t<div class=\"telyrx-comparable-medications__item-top\">\n\t\t\t\t<div class=\"telyrx-comparable-medications__item-info\">\n\t\t\t\t\t<h3 class=\"telyrx-comparable-medications__name\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"telyrx-comparable-medications__name-link\" href=\"https:\/\/telyrx.com\/pet-medications\/simparica\">\n\t\t\t\t\t\t\t\tSimparica Chewable Tablets\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/h3>\n\n\t\t\t\t\t\t\t\t\t\t\t<p class=\"telyrx-comparable-medications__price\">\n\t\t\t\t\t\t\tFrom $32.99\t\t\t\t\t\t<\/p>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<a class=\"telyrx-comparable-medications__cta\" href=\"https:\/\/telyrx.com\/pet-medications\/simparica\">\n\t\t\t\t\t\tView Product\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<p class=\"telyrx-comparable-medications__description\">\n\t\t\t\t\tSarolaner (Simparica) is a similar oral chewable medication belonging to the same drug class as NexGard that is used for flea and tick control in dogs.\t\t\t\t<\/p>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<hr class=\"telyrx-comparable-medications__divider\">\n\t\t\t\t\t<div class=\"telyrx-comparable-medications__item\">\n\t\t\t<div class=\"telyrx-comparable-medications__item-top\">\n\t\t\t\t<div class=\"telyrx-comparable-medications__item-info\">\n\t\t\t\t\t<h3 class=\"telyrx-comparable-medications__name\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"telyrx-comparable-medications__name-link\" href=\"https:\/\/telyrx.com\/pet-medications\/heartgard-plus\">\n\t\t\t\t\t\t\t\tHeartgard Plus Chewables\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/h3>\n\n\t\t\t\t\t\t\t\t\t\t\t<p class=\"telyrx-comparable-medications__price\">\n\t\t\t\t\t\t\tFrom $17.99\t\t\t\t\t\t<\/p>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<a class=\"telyrx-comparable-medications__cta\" href=\"https:\/\/telyrx.com\/pet-medications\/heartgard-plus\">\n\t\t\t\t\t\tView Product\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<p class=\"telyrx-comparable-medications__description\">\n\t\t\t\t\tHeartgard Plus is a monthly chewable designed for heartworm prevention and the treatment of intestinal parasites in dogs. It is not intended for flea or tick protection.\t\t\t\t<\/p>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<hr class=\"telyrx-comparable-medications__divider\">\n\t\t\t\t\t<div class=\"telyrx-comparable-medications__item\">\n\t\t\t<div class=\"telyrx-comparable-medications__item-top\">\n\t\t\t\t<div class=\"telyrx-comparable-medications__item-info\">\n\t\t\t\t\t<h3 class=\"telyrx-comparable-medications__name\">\n\t\t\t\t\t\t\t\t\t\t\t\t\tFipronil (Frontline Plus)\t\t\t\t\t\t\t\t\t\t\t<\/h3>\n\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<p class=\"telyrx-comparable-medications__description\">\n\t\t\t\t\tThis is a topical liquid medication applied to a dog\u2019s skin to kill fleas and ticks. It works externally rather than affecting parasites with medication in the dog\u2019s bloodstream.\t\t\t\t<\/p>\n\t\t\t\t\t<\/div>\n\n\t\t\t<\/div>\n\n\n<div class=\"telyrx-product-list telyrx-product-list--single wp-block-telyrx-product-list\">\n\t\t\t\t\t<a class=\"telyrx-product-list__card telyrx-product-list__card--single\" href=\"https:\/\/telyrx.com\/pet-medications\/nexgard\">\n\t\t\t\t\t\t\t<img\n\t\t\t\t\tclass=\"telyrx-product-list__image\"\n\t\t\t\t\tsrc=\"https:\/\/telyrx.com\/media\/catalog\/product\/n\/e\/nexgard_4.0_10_lb_tablets_2436_001_sq-bg_ai_gen_2_ai_gen_2.png\"\n\t\t\t\t\talt=\"NexGard\"\n\t\t\t\t\twidth=\"213\"\n\t\t\t\t\theight=\"213\"\n\t\t\t\t\tloading=\"lazy\"\n\t\t\t\t>\n\t\t\t\t\t\t<div class=\"telyrx-product-list__content\">\n\t\t\t\t<p class=\"telyrx-product-list__name\">NexGard<\/p>\n\t\t\t\t<span class=\"telyrx-product-list__cta telyrx-product-list__cta--yellow\">\n\t\t\t\t\tView Product\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t<\/a>\n\t<\/div>\n\n\n<div class=\"telyrx-product-list-section alignfull wp-block-telyrx-product-list\">\n\t<h2 class=\"telyrx-product-list-section__heading\" data-toc-hidden=\"true\">We Have NexGard in Stock. Get Yours Today!<\/h2>\n\t<div class=\"telyrx-product-list telyrx-product-list--footer-multi\">\n\t\t<div class=\"telyrx-product-list__grid\">\n\t\t\t\t\t\t\t<a class=\"telyrx-product-list__card\" href=\"https:\/\/telyrx.com\/pet-medications\/nexgard\">\n\t\t\t\t\t\t\t\t\t\t\t<img\n\t\t\t\t\t\t\tclass=\"telyrx-product-list__image\"\n\t\t\t\t\t\t\tsrc=\"https:\/\/telyrx.com\/media\/catalog\/product\/n\/e\/nexgard_4.0_10_lb_tablets_2436_001_sq-bg_ai_gen_2_ai_gen_2.png\"\n\t\t\t\t\t\t\talt=\"NexGard\"\n\t\t\t\t\t\t\twidth=\"213\"\n\t\t\t\t\t\t\theight=\"213\"\n\t\t\t\t\t\t\tloading=\"lazy\"\n\t\t\t\t\t\t>\n\t\t\t\t\t\t\t\t\t\t<div class=\"telyrx-product-list__content\">\n\t\t\t\t\t\t<p class=\"telyrx-product-list__name\">NexGard<\/p>\n\t\t\t\t\t\t<span class=\"telyrx-product-list__cta telyrx-product-list__cta--yellow\">\n\t\t\t\t\t\t\tOrder Now\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/a>\n\t\t\t\t\t<\/div>\n\t<\/div>\n\t\t\t<div class=\"telyrx-product-list-section__extra\">\n\t\t\t<p class=\"has-muted-color has-text-color has-urbanist-font-family\" style=\"font-size:0.875rem;font-style:italic;font-weight:400;line-height:1.571\"><strong>Important:<\/strong> Information on this page is for educational purposes only. Prescribing decisions are made by independent, licensed providers. TelyRx operates technology-enabled pharmacies and a telehealth platform that connects patients with licensed providers. Prescriptions, when provider-approved and issued, are filled and shipped by TelyRx-affiliated pharmacies. We do not employ physicians or make prescribing decisions. Learn more about our editorial standards <a href=\"\/blog\/editorial-standards\/\">here<\/a>.<\/p>\t\t<\/div>\n\t<\/div>\n","protected":false},"excerpt":{"rendered":"<p>NexGard is a monthly chewable tablet for dogs used to provide protection against fleas and ticks. <\/p>\n<p>This medication is formulated as a beef-flavored tablet and is commonly recommended by veterinarians as a component of a parasite control program for dogs. <\/p>\n<p>Providers typically recommend NexGard for healthy dogs and puppies that are at least 8 weeks old and weigh at least 4 pounds.<\/p>\n","protected":false},"author":2,"featured_media":8973,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"single-medication","format":"standard","meta":{"content-type":"","telyrx_subtitle":"Uses, Side Effects, Dosage & FAQs (2026 Guide)","telyrx_last_updated":"2026-06-02T14:37","telyrx_reviewer_name":"Andy Acevedo","telyrx_reviewer_credentials":"PharmD","telyrx_reviewer_job_title":"Pharmacist","telyrx_reviewer_affiliation":"TelyRx","telyrx_reviewer_url":"","telyrx_show_reviewer_job_title":"0","telyrx_show_reviewer_affiliation":"0","telyrx_show_toc":"1","telyrx_reviewer_bio":"","telyrx_reviewer_avatar":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","_telyrx_clean_url":"\/pet-medications\/nexgard\/what-is\/"},"categories":[86],"tags":[],"class_list":["post-8972","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medications"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.6 (Yoast SEO v27.6) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>What Is NexGard? Uses, Side Effects, Dosage, and FAQs<\/title>\n<meta name=\"description\" content=\"Learn what NexGard is, how it works, common side effects, and how to get it prescribed online through TelyRx.com\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/telyrx.com\/blog\/medications\/what-is-nexgard\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"What Is NexGard?\" \/>\n<meta property=\"og:description\" content=\"Learn what NexGard is, how it works, common side effects, and how to get it prescribed online through TelyRx.com\" \/>\n<meta property=\"og:url\" content=\"https:\/\/telyrx.com\/blog\/medications\/what-is-nexgard\/\" \/>\n<meta property=\"og:site_name\" content=\"TelyRx Blog\" \/>\n<meta property=\"article:published_time\" content=\"2026-06-02T14:37:23+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-06-02T14:37:36+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/telyrx.com\/blog\/wp-content\/uploads\/2026\/06\/nexgard_4.0_10_lb_tablets_2436_001_sq-bg_ai_gen_2_ai_gen_2.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"900\" \/>\n\t<meta property=\"og:image:height\" content=\"900\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Mariah Powers\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Mariah Powers\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/telyrx.com\\\/blog\\\/medications\\\/what-is-nexgard\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/telyrx.com\\\/blog\\\/medications\\\/what-is-nexgard\\\/\"},\"author\":{\"name\":\"Mariah Powers\",\"@id\":\"https:\\\/\\\/telyrx.com\\\/blog\\\/#\\\/schema\\\/person\\\/f1042a29c24ab7dd3c5f0fff9a06746b\"},\"headline\":\"What Is NexGard?\",\"datePublished\":\"2026-06-02T14:37:23+00:00\",\"dateModified\":\"2026-06-02T14:37:23+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/telyrx.com\\\/blog\\\/medications\\\/what-is-nexgard\\\/\"},\"wordCount\":1121,\"publisher\":{\"@id\":\"https:\\\/\\\/telyrx.com\\\/blog\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/telyrx.com\\\/blog\\\/medications\\\/what-is-nexgard\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/telyrx.com\\\/blog\\\/wp-content\\\/uploads\\\/2026\\\/06\\\/nexgard_4.0_10_lb_tablets_2436_001_sq-bg_ai_gen_2_ai_gen_2.jpg\",\"articleSection\":[\"Medications\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/telyrx.com\\\/blog\\\/medications\\\/what-is-nexgard\\\/\",\"url\":\"https:\\\/\\\/telyrx.com\\\/blog\\\/medications\\\/what-is-nexgard\\\/\",\"name\":\"What Is NexGard? 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