{"id":7588,"date":"2026-04-03T17:36:49","date_gmt":"2026-04-03T17:36:49","guid":{"rendered":"https:\/\/telyrx.com\/blog\/?p=7588"},"modified":"2026-04-07T20:46:50","modified_gmt":"2026-04-07T20:46:50","slug":"what-is-adapalene-and-benzoyl-peroxide","status":"publish","type":"post","link":"https:\/\/telyrx.com\/blog\/medications\/what-is-adapalene-and-benzoyl-peroxide\/","title":{"rendered":"What Is Adapalene and Benzoyl Peroxide?"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\" id=\"h-how-it-works\">How It Works<\/h2>\n\n\n\n<p>Adapalene and benzoyl peroxide works by clearing the pores and reducing inflammation. Adapalene binds to retinoic acid nuclear receptors in the skin and helps the skin shed dead skin cells. This prevents &#8220;plugs&#8221; in the pores common with people who are prone to acne. Adapalene also has anti-inflammatory properties to reduce redness and irritation during acne breakouts.<\/p>\n\n\n\n<p>Benzoyl peroxide introduces oxygen to kill the acne-causing bacteria living inside the pores. Benzoyl peroxide also acts as a keratolytic agent by peeling away the outer layer of skin and further clearing the pore.<\/p>\n\n\n\n<div class=\"quick-facts-card\">\n  <table class=\"quick-facts-table\">\n    <colgroup>\n      <col\/>\n      <col\/>\n    <\/colgroup>\n\n    <thead>\n      <tr>\n        <th colspan=\"2\">Quick Facts<\/th>\n      <\/tr>\n    <\/thead>\n\n    <tbody>\n      <tr>\n        <td><strong>Common Brands<\/strong><\/td>\n        <td>Epiduo, Epiduo Forte<\/td>\n      <\/tr>\n\n      <tr>\n         <td><strong>Drug Class<\/strong><\/td>\n        <td>Acne agent (retinoid and antiseptic combination)<\/td>\n      <\/tr>\n\n      <tr>\n        <td><strong>Generic Status<\/strong><\/td>\n        <td>Generic version available<\/td>\n      <\/tr>\n\n      <tr>\n         <td><strong>Availability<\/strong><\/td>\n        <td>Prescription only<\/td>\n    <\/tbody>\n  <\/table>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-dosing\">Dosing<\/h2>\n\n\n\n<p>Per standard guidelines, adapalene and benzoyl peroxide topical medication is most effective when applied consistently as part of a nighttime skincare routine. Since the gel is highly concentrated, using more than recommended will not make the drug work faster but can increase the risk of side effects like peeling.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Administration: <\/strong>Doctors typically recommend using a small, &#8220;pea-sized&#8221; amount of gel for the entire face. Standard guidelines recommend dotting the gel on the chin, forehead, and both cheeks, then spreading it in a thin, even layer across the entire face.<\/li>\n\n\n\n<li><strong>Frequency: <\/strong>Dermatologists usually advise patients to begin using the topical with applications every other night. This helps the skin acclimate to the high-potency gel. Once the patient has properly adjusted, their dermatologist may recommend nightly applications.<\/li>\n\n\n\n<li><strong>Preparation: <\/strong>It is advised to completely dry the skin prior to applying the gel. Damp skin can absorb retinoids too quickly, leading to symptoms like stinging and redness.<\/li>\n\n\n\n<li><strong>Areas to avoid: <\/strong>The skin around the eyes, corners of the nose, and lips are all sensitive and prone to dryness and cracking. Per standard guidelines, patients should avoid applying adapalene and benzoyl peroxide gel to these areas.<\/li>\n<\/ul>\n\n\n\n<p><em><strong>Note:<\/strong> Dosing information below is educational only. Your prescribing physician will determine your specific dose based on your individual health needs.\u00a0Always follow your healthcare provider\u2019s instructions for exact dosing.<\/em><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-uses\">Uses<\/h2>\n\n\n\n<p><strong>FDA-Approved Uses<\/strong><\/p>\n\n\n\n<p>Adapalene and benzoyl peroxide is FDA-approved to treat the blackheads, whiteheads, and inflammatory acne lesions that can occur in people with acne vulgaris.<\/p>\n\n\n\n<p><strong>Off-Label Uses<\/strong><\/p>\n\n\n\n<p>You may see adapalene and benzoyl peroxide prescribed for uses that are not &#8220;FDA-approved.&#8221; This is a common and legal practice called &#8220;off-label&#8221; prescribing, where a doctor uses their clinical judgment to prescribe a drug for a different (but well-researched) purpose.<\/p>\n\n\n\n<p>Common off-label uses for adapalene and benzoyl peroxide currently found in clinical research and practice include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Anti-aging and wrinkle treatment: <\/strong>The adapalene retinoid component in this topical gel can help improve skin texture and reduce fine lines.\u00a0<\/li>\n\n\n\n<li><strong>Keratosis pilaris: <\/strong>Providers may recommend adapalene and benzoyl peroxide for people with keratosis pilaris, a condition that creates a &#8220;chicken skin\u201d-like texture on the arms and legs.<\/li>\n\n\n\n<li><strong>Body acne: <\/strong>Doctors may prescribe adapalene and benzoyl peroxide off-label to treat acne on the chest or back.<\/li>\n<\/ul>\n\n\n<div class=\"telyrx-email-cta alignfull wp-block-telyrx-email-signup\">\n\t<h2 class=\"telyrx-email-cta__heading\" data-toc-hidden=\"true\">Get Savings Updates<\/h2>\n\t<p class=\"telyrx-email-cta__description\">Join our mailing list for exclusive deals and more.<\/p>\n\t\t\t<form\n\t\t\tid=\"telyrx-email-form-1\"\n\t\t\tclass=\"telyrx-email-cta__form\"\n\t\t\tdata-portal-id=\"46401311\"\n\t\t\tdata-form-id=\"14e1d7d5-6b17-4228-b42e-c06d1a6c240b\"\n\t\t\tdata-i18n=\"{&quot;subscribe&quot;:&quot;Subscribe&quot;,&quot;success&quot;:&quot;Thanks! You&#039;re subscribed.&quot;,&quot;error&quot;:&quot;Something went wrong. Please try again.&quot;}\"\n\t\t>\n\t\t\t<div class=\"telyrx-email-cta__pill\">\n\t\t\t\t<input\n\t\t\t\t\ttype=\"email\"\n\t\t\t\t\tname=\"email\"\n\t\t\t\t\tclass=\"telyrx-email-cta__input\"\n\t\t\t\t\tplaceholder=\"Enter your email\"\n\t\t\t\t\trequired\n\t\t\t\t\tautocomplete=\"email\"\n\t\t\t\t\/>\n\t\t\t\t<button type=\"submit\" class=\"telyrx-email-cta__button\">\n\t\t\t\t\tSubscribe\t\t\t\t<\/button>\n\t\t\t<\/div>\n\t\t\t<p class=\"telyrx-email-cta__status\" aria-live=\"polite\"><\/p>\n\t\t<\/form>\n\t\t<noscript>\n\t\t\t<p class=\"telyrx-email-cta__noscript\">Please enable JavaScript to use the signup form.<\/p>\n\t\t<\/noscript>\n\t<\/div>\n\n\n\n<section class=\"telyrx-side-effects\" data-toc-title=\"Side Effects\">\n\t<h2 class=\"telyrx-side-effects__heading\">Side Effects<\/h2>\n\t<hr class=\"telyrx-side-effects__separator\">\n\t<div class=\"telyrx-side-effects__content\">\n\t\t\n\n<p>Most people who use adapalene and benzoyl peroxide experience side effects during the initial stages of their treatment. Gradual introduction to the drug can reduce the severity of these side effects, which typically taper off as the patient acclimates to the medication.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-common-side-effects\">Common Side Effects<\/h3>\n\n\n\n<div class=\"telyrx-side-effects-chip telyrx-side-effects-chip--common\">\n\t\n\n<p>Common side effects from using adapalene and benzoyl peroxide include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Dry or flaky skin<\/li>\n\n\n\n<li>Skin that appears pink or lightly sunburnt<\/li>\n\n\n\n<li>Burning or stinging immediately after application<\/li>\n\n\n\n<li>Photosensitivity<\/li>\n<\/ul>\n\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-serious-side-effects\">Serious Side Effects<\/h3>\n\n\n\n<div class=\"telyrx-side-effects-chip telyrx-side-effects-chip--serious\">\n\t\n\n<p>Serious side effects are rare, but it&#8217;s important to know what to look for if they do occur.<\/p>\n\n\n\n<p>Serious side effects from using adapalene and benzoyl peroxide can include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Contact dermatitis: <\/strong>Adapalene and benzoyl peroxide can lead to contact dermatitis, a condition that produces severe, painful peeling, blistering, and oozing skin.<\/li>\n\n\n\n<li><strong>Hypersensitivity: <\/strong>This medication can cause hypersensitivity, or intense itching and irritation that spread beyond the application site.<\/li>\n\n\n\n<li><strong>Severe allergic reaction: <\/strong>Adapalene and benzoyl peroxide can cause anaphylaxis in people who are allergic to one or more of the gel&#8217;s ingredients.<\/li>\n<\/ul>\n\n<\/div>\n\n\n\n<p class=\"has-muted-color has-text-color\" style=\"font-size:0.875rem\"><em>Call your doctor immediately if you experience any concerning or prolonged symptoms.<\/em><\/p>\n\n\t<\/div>\n<\/section>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-pharmacist-tips\">Pharmacist Tips<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-protect-your-linens\">Protect Your Linens<\/h3>\n\n\n\n<p>Benzoyl peroxide has bleaching properties and can leave permanent discolorations on sheets, pillowcases, towels, and other linens. It is recommended to use white linens, or to ensure the gel is completely dry before lying down in bed.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-try-the-skincare-sandwich\">Try the Skincare Sandwich<\/h3>\n\n\n\n<p>If you have sensitive skin, it is advised to apply a base layer of moisturizer on the face, followed by the adapalene and benzoyl peroxide gel, and another moisturizer layer on top to act as a buffer. This can help prevent redness and irritation without compromising the medication&#8217;s healing abilities.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-take-caution-in-the-sun\">Take Caution in the Sun<\/h3>\n\n\n\n<p>Increased photosensitivity is one of adapalene and benzoyl peroxide&#8217;s common side effects. Patients are advised to use broad-spectrum SPF 30+ sunscreen every morning and wear protective clothing outdoors, even on cloudy days.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-streamline-your-skincare-regimen\">Streamline Your Skincare Regimen<\/h3>\n\n\n\n<p>Patients who use adapalene and benzoyl peroxide gel are generally advised to stop using other topicals with active ingredients. These include physical scrubs and toners with high alcohol content.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-more-is-not-better\">More is Not Better<\/h3>\n\n\n\n<p>According to the drug&#8217;s standard guidelines, applying the gel consistently every night is most effective for acne treatment. People who use the topical multiple times per day often need to take a break due to the increased irritation.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-drug-interactions\">Drug Interactions<\/h2>\n\n\n\n<p>Adapalene and benzoyl peroxide is a topical medication so systemic changes are not likely. However, the drug can still interact with other substances at the skin surface. Known interactions with adapalene and benzoyl peroxide include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Other acne medications: <\/strong>Using adapalene and benzoyl peroxide simultaneously with salicylic acid, glycolic acid, or sulfur-based skin products can produce cumulative irritation and cause burns on the skin barrier.<\/li>\n\n\n\n<li><strong>Topical antibiotics: <\/strong>Applying certain topical antibiotics at the same time as adapalene and benzoyl peroxide can cause discolored skin and reduce the efficacy of both drugs.<\/li>\n\n\n\n<li><strong>Astringents and spices: <\/strong>Skincare products containing high concentrations of alcohol, lime, or menthol can cause extreme stinging on skin being treated with adapalene and benzoyl peroxide.<\/li>\n\n\n\n<li><strong>Waxing: <\/strong>It is recommended to avoid facial waxing while using the adapalene and benzoyl peroxide topical gel. The retinoid component makes the skin more fragile and susceptible to lifting or tearing when wax is applied.<\/li>\n<\/ul>\n\n\n\n<p>Always give your doctor and pharmacist a complete list of all your medications, vitamins, and supplements to check for potential interactions.<\/p>\n\n\n\n<section class=\"telyrx-faq-section\" data-toc-title=\"FAQs\">\n\t<h2 class=\"telyrx-faq-heading\">FAQs<\/h2>\n\t\t<div class=\"telyrx-faq-items\">\n\t\t\n\n<details class=\"telyrx-faq-item\">\n\t<summary class=\"telyrx-faq-question\">\n\t\t<span class=\"telyrx-faq-question-text\">Why does this gel bleach my towels and pillowcases?<\/span>\n\t\t<svg class=\"telyrx-faq-chevron\" width=\"20\" height=\"20\" viewBox=\"0 0 20 20\" fill=\"none\" aria-hidden=\"true\">\n\t\t\t<path d=\"M5 7.5L10 12.5L15 7.5\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n\t\t<\/svg>\n\t<\/summary>\n\t<div class=\"telyrx-faq-answer\">\n\t\t\n\n<p>This gel bleaches towels and pillowcases due to its benzoyl peroxide component. Benzoyl peroxide kills bacteria through oxidization, a process that also breaks down pigments and dyes in fabric and creates a bleaching effect.<\/p>\n\n\t<\/div>\n<\/details>\n\n\n\n<details class=\"telyrx-faq-item\">\n\t<summary class=\"telyrx-faq-question\">\n\t\t<span class=\"telyrx-faq-question-text\">Does adapalene\/benzoyl peroxide cause a &#8220;purge&#8221; phase where acne gets worse?<\/span>\n\t\t<svg class=\"telyrx-faq-chevron\" width=\"20\" height=\"20\" viewBox=\"0 0 20 20\" fill=\"none\" aria-hidden=\"true\">\n\t\t\t<path d=\"M5 7.5L10 12.5L15 7.5\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n\t\t<\/svg>\n\t<\/summary>\n\t<div class=\"telyrx-faq-answer\">\n\t\t\n\n<p>Generally yes, patients who use adapalene and benzoyl peroxide gel may experience a purge phase where acne gets worse. As the retinoid speeds up skin cell turnover, it pushes existing clogs to the surface. Many people notice initial breakouts for the first 2 to 4 weeks, then clearer skin after that.<\/p>\n\n\t<\/div>\n<\/details>\n\n\n\n<details class=\"telyrx-faq-item\">\n\t<summary class=\"telyrx-faq-question\">\n\t\t<span class=\"telyrx-faq-question-text\">Can I use moisturizer before applying the gel to reduce irritation?<\/span>\n\t\t<svg class=\"telyrx-faq-chevron\" width=\"20\" height=\"20\" viewBox=\"0 0 20 20\" fill=\"none\" aria-hidden=\"true\">\n\t\t\t<path d=\"M5 7.5L10 12.5L15 7.5\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n\t\t<\/svg>\n\t<\/summary>\n\t<div class=\"telyrx-faq-answer\">\n\t\t\n\n<p>Yes, you can use moisturizer before applying the gel to reduce irritation. The sandwich method uses top and bottom layers of moisturizer to buffer the topical gel. Moisturizer that is non-comedogenic, or formulated to not clog pores, is recommended.<\/p>\n\n\t<\/div>\n<\/details>\n\n\n\n<details class=\"telyrx-faq-item\">\n\t<summary class=\"telyrx-faq-question\">\n\t\t<span class=\"telyrx-faq-question-text\">Why does my face burn or sting when I apply it?<\/span>\n\t\t<svg class=\"telyrx-faq-chevron\" width=\"20\" height=\"20\" viewBox=\"0 0 20 20\" fill=\"none\" aria-hidden=\"true\">\n\t\t\t<path d=\"M5 7.5L10 12.5L15 7.5\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n\t\t<\/svg>\n\t<\/summary>\n\t<div class=\"telyrx-faq-answer\">\n\t\t\n\n<p>If your face burns or stings when you apply adapalene and benzoyl peroxide gel medication, this may be due to a compromised skin barrier. Reducing frequency of use for the topical gel or applying a moisturizer before using the medication can help reduce this issue.<\/p>\n\n\t<\/div>\n<\/details>\n\n\n\n<details class=\"telyrx-faq-item\">\n\t<summary class=\"telyrx-faq-question\">\n\t\t<span class=\"telyrx-faq-question-text\">What is the difference between Epiduo and Epiduo Forte?<\/span>\n\t\t<svg class=\"telyrx-faq-chevron\" width=\"20\" height=\"20\" viewBox=\"0 0 20 20\" fill=\"none\" aria-hidden=\"true\">\n\t\t\t<path d=\"M5 7.5L10 12.5L15 7.5\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n\t\t<\/svg>\n\t<\/summary>\n\t<div class=\"telyrx-faq-answer\">\n\t\t\n\n<p>The difference between Epiduo and Epiduo Forte is the concentration of adapalene retinoid. Epiduo (0.1%) is typically recommended for mild or more sensitive acne, while Epiduo Forte (0.3%) is a stronger and more potent option for severe or resistant inflammatory acne.<\/p>\n\n\t<\/div>\n<\/details>\n\n\n\n<details class=\"telyrx-faq-item\">\n\t<summary class=\"telyrx-faq-question\">\n\t\t<span class=\"telyrx-faq-question-text\">Can I use salicylic acid or vitamin C while using this medication?<\/span>\n\t\t<svg class=\"telyrx-faq-chevron\" width=\"20\" height=\"20\" viewBox=\"0 0 20 20\" fill=\"none\" aria-hidden=\"true\">\n\t\t\t<path d=\"M5 7.5L10 12.5L15 7.5\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n\t\t<\/svg>\n\t<\/summary>\n\t<div class=\"telyrx-faq-answer\">\n\t\t\n\n<p>It is not recommended to use salicylic acid or vitamin C while first using adapalene and benzoyl peroxide because this can irritate the skin. Your provider may allow vitamin C once the skin is stable, but most doctors advise patients to avoid salicylic acid completely while using the topical gel.<\/p>\n\n\t<\/div>\n<\/details>\n\n\n\n<details class=\"telyrx-faq-item\">\n\t<summary class=\"telyrx-faq-question\">\n\t\t<span class=\"telyrx-faq-question-text\">How long does it take to see results for acne?<\/span>\n\t\t<svg class=\"telyrx-faq-chevron\" width=\"20\" height=\"20\" viewBox=\"0 0 20 20\" fill=\"none\" aria-hidden=\"true\">\n\t\t\t<path d=\"M5 7.5L10 12.5L15 7.5\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n\t\t<\/svg>\n\t<\/summary>\n\t<div class=\"telyrx-faq-answer\">\n\t\t\n\n<p>Patients may see their acne begin to clear up within 4 weeks of first using adapalene and benzoyl peroxide gel, but for many people, the most significant results begin to appear within 12 weeks.<\/p>\n\n\t<\/div>\n<\/details>\n\n\n\n<details class=\"telyrx-faq-item\">\n\t<summary class=\"telyrx-faq-question\">\n\t\t<span class=\"telyrx-faq-question-text\">Is it safe to use this medication during pregnancy?<\/span>\n\t\t<svg class=\"telyrx-faq-chevron\" width=\"20\" height=\"20\" viewBox=\"0 0 20 20\" fill=\"none\" aria-hidden=\"true\">\n\t\t\t<path d=\"M5 7.5L10 12.5L15 7.5\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n\t\t<\/svg>\n\t<\/summary>\n\t<div class=\"telyrx-faq-answer\">\n\t\t\n\n<p>As a precaution, most providers will not prescribe adapalene and benzoyl peroxide and other retinoid medications during pregnancy. Talk to your doctor or OB\/GYN about pregnancy-safe acne alternatives.<\/p>\n\n\t<\/div>\n<\/details>\n\n\n\n<details class=\"telyrx-faq-item\">\n\t<summary class=\"telyrx-faq-question\">\n\t\t<span class=\"telyrx-faq-question-text\">Why should I apply it at night instead of the morning?<\/span>\n\t\t<svg class=\"telyrx-faq-chevron\" width=\"20\" height=\"20\" viewBox=\"0 0 20 20\" fill=\"none\" aria-hidden=\"true\">\n\t\t\t<path d=\"M5 7.5L10 12.5L15 7.5\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n\t\t<\/svg>\n\t<\/summary>\n\t<div class=\"telyrx-faq-answer\">\n\t\t\n\n<p>It is recommended to apply the topical gel at night instead of the morning because sunlight can degrade adapalene and make the retinoid less effective. Since the medication also increases sun sensitivity, it is considered safer and more protective for your skin to apply the gel at night.<\/p>\n\n\t<\/div>\n<\/details>\n\n\n\n<details class=\"telyrx-faq-item\">\n\t<summary class=\"telyrx-faq-question\">\n\t\t<span class=\"telyrx-faq-question-text\">Can I wax my eyebrows or lip while using this gel?<\/span>\n\t\t<svg class=\"telyrx-faq-chevron\" width=\"20\" height=\"20\" viewBox=\"0 0 20 20\" fill=\"none\" aria-hidden=\"true\">\n\t\t\t<path d=\"M5 7.5L10 12.5L15 7.5\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n\t\t<\/svg>\n\t<\/summary>\n\t<div class=\"telyrx-faq-answer\">\n\t\t\n\n<p>Generally, patients are strongly advised not to wax their eyebrows or lips while using this gel. While using the topical gel, skin may be more fragile and prone to damage from waxing. Threading or plucking may be considered gentler alternatives.<\/p>\n\n\t<\/div>\n<\/details>\n\n\n\n<details class=\"telyrx-faq-item\">\n\t<summary class=\"telyrx-faq-question\">\n\t\t<span class=\"telyrx-faq-question-text\">Does this medication help with acne scars?<\/span>\n\t\t<svg class=\"telyrx-faq-chevron\" width=\"20\" height=\"20\" viewBox=\"0 0 20 20\" fill=\"none\" aria-hidden=\"true\">\n\t\t\t<path d=\"M5 7.5L10 12.5L15 7.5\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n\t\t<\/svg>\n\t<\/summary>\n\t<div class=\"telyrx-faq-answer\">\n\t\t\n\n<p>Adapalene and benzoyl peroxide helps with post-inflammatory hyperpigmentation, or red or dark marks left behind by acne breakouts. However, the gel is less effective for healing pitted or atrophic acne scarring, which often requires professional procedures.<\/p>\n\n\t<\/div>\n<\/details>\n\n\n\n<details class=\"telyrx-faq-item\">\n\t<summary class=\"telyrx-faq-question\">\n\t\t<span class=\"telyrx-faq-question-text\">How much gel should I actually use for my whole face?<\/span>\n\t\t<svg class=\"telyrx-faq-chevron\" width=\"20\" height=\"20\" viewBox=\"0 0 20 20\" fill=\"none\" aria-hidden=\"true\">\n\t\t\t<path d=\"M5 7.5L10 12.5L15 7.5\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n\t\t<\/svg>\n\t<\/summary>\n\t<div class=\"telyrx-faq-answer\">\n\t\t\n\n<p>The &#8220;pea-sized rule&#8221; is recommended for adapalene and benzoyl peroxide. Per standard instructions, patients are advised to dispense a pea-sized amount of the gel, then dotting it on their forehead, cheeks, and chin before spreading in a thin layer across the entire face.<\/p>\n\n\t<\/div>\n<\/details>\n\n\n\n<details class=\"telyrx-faq-item\">\n\t<summary class=\"telyrx-faq-question\">\n\t\t<span class=\"telyrx-faq-question-text\">Can I use this as a spot treatment for single pimples?<\/span>\n\t\t<svg class=\"telyrx-faq-chevron\" width=\"20\" height=\"20\" viewBox=\"0 0 20 20\" fill=\"none\" aria-hidden=\"true\">\n\t\t\t<path d=\"M5 7.5L10 12.5L15 7.5\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n\t\t<\/svg>\n\t<\/summary>\n\t<div class=\"telyrx-faq-answer\">\n\t\t\n\n<p>No, it is not advised to use adapalene and benzoyl peroxide gel as a spot treatment for single pimples. This medication is considered a field treatment, meaning it is applied to an entire area to prevent acne from forming.<\/p>\n\n\t<\/div>\n<\/details>\n\n\n\n<details class=\"telyrx-faq-item\">\n\t<summary class=\"telyrx-faq-question\">\n\t\t<span class=\"telyrx-faq-question-text\">Can I wear makeup over this medication?<\/span>\n\t\t<svg class=\"telyrx-faq-chevron\" width=\"20\" height=\"20\" viewBox=\"0 0 20 20\" fill=\"none\" aria-hidden=\"true\">\n\t\t\t<path d=\"M5 7.5L10 12.5L15 7.5\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n\t\t<\/svg>\n\t<\/summary>\n\t<div class=\"telyrx-faq-answer\">\n\t\t\n\n<p>Yes, patients can wear makeup over adapalene and benzoyl peroxide gel, but they are advised to wait until the medication has completely dried. For best results, non-comedogenic and oil-free makeup is recommended.<\/p>\n\n\t<\/div>\n<\/details>\n\n\n\n<details class=\"telyrx-faq-item\">\n\t<summary class=\"telyrx-faq-question\">\n\t\t<span class=\"telyrx-faq-question-text\">Can I use this on my back or chest acne?<\/span>\n\t\t<svg class=\"telyrx-faq-chevron\" width=\"20\" height=\"20\" viewBox=\"0 0 20 20\" fill=\"none\" aria-hidden=\"true\">\n\t\t\t<path d=\"M5 7.5L10 12.5L15 7.5\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n\t\t<\/svg>\n\t<\/summary>\n\t<div class=\"telyrx-faq-answer\">\n\t\t\n\n<p>Yes, you can apply adapalene and benzoyl peroxide gel to your chest or back acne as long as your provider approves of this off-label use.<\/p>\n\n\t<\/div>\n<\/details>\n\n\n\n<details class=\"telyrx-faq-item\">\n\t<summary class=\"telyrx-faq-question\">\n\t\t<span class=\"telyrx-faq-question-text\">Does this medication work for blackheads and whiteheads?<\/span>\n\t\t<svg class=\"telyrx-faq-chevron\" width=\"20\" height=\"20\" viewBox=\"0 0 20 20\" fill=\"none\" aria-hidden=\"true\">\n\t\t\t<path d=\"M5 7.5L10 12.5L15 7.5\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n\t\t<\/svg>\n\t<\/summary>\n\t<div class=\"telyrx-faq-answer\">\n\t\t\n\n<p>Yes, adapalene and benzoyl peroxide works for treating blackheads and whiteheads. The gel is formulated to prevent pore clogging and prevent all comedones, a collective term for blackheads and whiteheads.<\/p>\n\n\t<\/div>\n<\/details>\n\n\n\n<details class=\"telyrx-faq-item\">\n\t<summary class=\"telyrx-faq-question\">\n\t\t<span class=\"telyrx-faq-question-text\">Why do I need to avoid harsh cleansers or scrubs while using this?<\/span>\n\t\t<svg class=\"telyrx-faq-chevron\" width=\"20\" height=\"20\" viewBox=\"0 0 20 20\" fill=\"none\" aria-hidden=\"true\">\n\t\t\t<path d=\"M5 7.5L10 12.5L15 7.5\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n\t\t<\/svg>\n\t<\/summary>\n\t<div class=\"telyrx-faq-answer\">\n\t\t\n\n<p>Adapalene and benzoyl peroxide chemically exfoliates your skin, so using facial scrubs and other harsh cleaners at the same time can lead to raw, damaged skin and intense inflammation.<\/p>\n\n\t<\/div>\n<\/details>\n\n\t<\/div>\n<\/section>\n<script type=\"application\/ld+json\">{\"@context\":\"https:\/\/schema.org\",\"@type\":\"FAQPage\",\"mainEntity\":[{\"@type\":\"Question\",\"name\":\"Why does this gel bleach my towels and pillowcases?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"This gel bleaches towels and pillowcases due to its benzoyl peroxide component. Benzoyl peroxide kills bacteria through oxidization, a process that also breaks down pigments and dyes in fabric and creates a bleaching effect.\"}},{\"@type\":\"Question\",\"name\":\"Does adapalene\/benzoyl peroxide cause a \\\"purge\\\" phase where acne gets worse?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Generally yes, patients who use adapalene and benzoyl peroxide gel may experience a purge phase where acne gets worse. As the retinoid speeds up skin cell turnover, it pushes existing clogs to the surface. Many people notice initial breakouts for the first 2 to 4 weeks, then clearer skin after that.\"}},{\"@type\":\"Question\",\"name\":\"Can I use moisturizer before applying the gel to reduce irritation?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Yes, you can use moisturizer before applying the gel to reduce irritation. The sandwich method uses top and bottom layers of moisturizer to buffer the topical gel. Moisturizer that is non-comedogenic, or formulated to not clog pores, is recommended.\"}},{\"@type\":\"Question\",\"name\":\"Why does my face burn or sting when I apply it?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"If your face burns or stings when you apply adapalene and benzoyl peroxide gel medication, this may be due to a compromised skin barrier. Reducing frequency of use for the topical gel or applying a moisturizer before using the medication can help reduce this issue.\"}},{\"@type\":\"Question\",\"name\":\"What is the difference between Epiduo and Epiduo Forte?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"The difference between Epiduo and Epiduo Forte is the concentration of adapalene retinoid. Epiduo (0.1%) is typically recommended for mild or more sensitive acne, while Epiduo Forte (0.3%) is a stronger and more potent option for severe or resistant inflammatory acne.\"}},{\"@type\":\"Question\",\"name\":\"Can I use salicylic acid or vitamin C while using this medication?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"It is not recommended to use salicylic acid or vitamin C while first using adapalene and benzoyl peroxide because this can irritate the skin. Your provider may allow vitamin C once the skin is stable, but most doctors advise patients to avoid salicylic acid completely while using the topical gel.\"}},{\"@type\":\"Question\",\"name\":\"How long does it take to see results for acne?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Patients may see their acne begin to clear up within 4 weeks of first using adapalene and benzoyl peroxide gel, but for many people, the most significant results begin to appear within 12 weeks.\"}},{\"@type\":\"Question\",\"name\":\"Is it safe to use this medication during pregnancy?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"As a precaution, most providers will not prescribe adapalene and benzoyl peroxide and other retinoid medications during pregnancy. Talk to your doctor or OB\/GYN about pregnancy-safe acne alternatives.\"}},{\"@type\":\"Question\",\"name\":\"Why should I apply it at night instead of the morning?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"It is recommended to apply the topical gel at night instead of the morning because sunlight can degrade adapalene and make the retinoid less effective. Since the medication also increases sun sensitivity, it is considered safer and more protective for your skin to apply the gel at night.\"}},{\"@type\":\"Question\",\"name\":\"Can I wax my eyebrows or lip while using this gel?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Generally, patients are strongly advised not to wax their eyebrows or lips while using this gel. While using the topical gel, skin may be more fragile and prone to damage from waxing. Threading or plucking may be considered gentler alternatives.\"}},{\"@type\":\"Question\",\"name\":\"Does this medication help with acne scars?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Adapalene and benzoyl peroxide helps with post-inflammatory hyperpigmentation, or red or dark marks left behind by acne breakouts. However, the gel is less effective for healing pitted or atrophic acne scarring, which often requires professional procedures.\"}},{\"@type\":\"Question\",\"name\":\"How much gel should I actually use for my whole face?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"The \\\"pea-sized rule\\\" is recommended for adapalene and benzoyl peroxide. Per standard instructions, patients are advised to dispense a pea-sized amount of the gel, then dotting it on their forehead, cheeks, and chin before spreading in a thin layer across the entire face.\"}},{\"@type\":\"Question\",\"name\":\"Can I use this as a spot treatment for single pimples?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"No, it is not advised to use adapalene and benzoyl peroxide gel as a spot treatment for single pimples. This medication is considered a field treatment, meaning it is applied to an entire area to prevent acne from forming.\"}},{\"@type\":\"Question\",\"name\":\"Can I wear makeup over this medication?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Yes, patients can wear makeup over adapalene and benzoyl peroxide gel, but they are advised to wait until the medication has completely dried. For best results, non-comedogenic and oil-free makeup is recommended.\"}},{\"@type\":\"Question\",\"name\":\"Can I use this on my back or chest acne?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Yes, you can apply adapalene and benzoyl peroxide gel to your chest or back acne as long as your provider approves of this off-label use.\"}},{\"@type\":\"Question\",\"name\":\"Does this medication work for blackheads and whiteheads?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Yes, adapalene and benzoyl peroxide works for treating blackheads and whiteheads. The gel is formulated to prevent pore clogging and prevent all comedones, a collective term for blackheads and whiteheads.\"}},{\"@type\":\"Question\",\"name\":\"Why do I need to avoid harsh cleansers or scrubs while using this?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Adapalene and benzoyl peroxide chemically exfoliates your skin, so using facial scrubs and other harsh cleaners at the same time can lead to raw, damaged skin and intense inflammation.\"}}]}<\/script>\n\n<div class=\"telyrx-comparable-medications wp-block-telyrx-comparable-medications\">\n\t<h2 class=\"telyrx-comparable-medications__title\">Comparable Medications<\/h2>\n\t\t\t<div class=\"telyrx-comparable-medications__intro\">\n\n<p><strong><strong><strong>Adapalene and Benzoyl Peroxide, Epiduo, Epiduo Forte, Adapalene, Benzoyl Peroxide, or Clindamycin and Benzoyl Peroxide?<\/strong><\/strong><\/strong><\/p>\n\n\n\n<p>Adapalene and benzoyl peroxide is a potent topical gel that attacks acne using multiple pathways and helps restore the skin. Your doctor may recommend this medication or an alternative to adapalene and benzoyl peroxide, depending on factors like your age, medical history, and severity of symptoms.<\/p>\n\n<\/div>\n\t\t\t\t<div class=\"telyrx-comparable-medications__item\">\n\t\t\t<div class=\"telyrx-comparable-medications__item-top\">\n\t\t\t\t<div class=\"telyrx-comparable-medications__item-info\">\n\t\t\t\t\t<h3 class=\"telyrx-comparable-medications__name\">\n\t\t\t\t\t\t\t\t\t\t\t\t\tEpiduo and Epiduo Forte\t\t\t\t\t\t\t\t\t\t\t<\/h3>\n\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<p class=\"telyrx-comparable-medications__description\">\n\t\t\t\t\tThese brand-name versions of generic adapalene and benzoyl peroxide both contain the same active ingredients in different concentrations. Epiduo (0.1%) is less potent and typically used to treat mild or sensitive acne, while Epiduo Forte (0.3%) is used to treat resistant or inflammatory acne.\t\t\t\t<\/p>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<hr class=\"telyrx-comparable-medications__divider\">\n\t\t\t\t\t<div class=\"telyrx-comparable-medications__item\">\n\t\t\t<div class=\"telyrx-comparable-medications__item-top\">\n\t\t\t\t<div class=\"telyrx-comparable-medications__item-info\">\n\t\t\t\t\t<h3 class=\"telyrx-comparable-medications__name\">\n\t\t\t\t\t\t\t\t\t\t\t\t\tAdapalene\t\t\t\t\t\t\t\t\t\t\t<\/h3>\n\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<p class=\"telyrx-comparable-medications__description\">\n\t\t\t\t\tSold under the brand name Differin, adapalene contains a retinoid component without an antiseptic agent like benzoyl peroxide. This medication is effective for clearing pores, but does not provide an antibacterial treatment.\t\t\t\t<\/p>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<hr class=\"telyrx-comparable-medications__divider\">\n\t\t\t\t\t<div class=\"telyrx-comparable-medications__item\">\n\t\t\t<div class=\"telyrx-comparable-medications__item-top\">\n\t\t\t\t<div class=\"telyrx-comparable-medications__item-info\">\n\t\t\t\t\t<h3 class=\"telyrx-comparable-medications__name\">\n\t\t\t\t\t\t\t\t\t\t\t\t\tBenzoyl peroxide\t\t\t\t\t\t\t\t\t\t\t<\/h3>\n\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<p class=\"telyrx-comparable-medications__description\">\n\t\t\t\t\tBrand-name medications like PanOxyl and Zapzyt contain benzoyl peroxide as the active ingredient. These products kill bacteria, but lack a retinoid component to regulate skin cell turnover and clear pores.\t\t\t\t<\/p>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<hr class=\"telyrx-comparable-medications__divider\">\n\t\t\t\t\t<div class=\"telyrx-comparable-medications__item\">\n\t\t\t<div class=\"telyrx-comparable-medications__item-top\">\n\t\t\t\t<div class=\"telyrx-comparable-medications__item-info\">\n\t\t\t\t\t<h3 class=\"telyrx-comparable-medications__name\">\n\t\t\t\t\t\t\t\t\t\t\t\t\tClindamycin\/benzoyl peroxide\t\t\t\t\t\t\t\t\t\t\t<\/h3>\n\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<p class=\"telyrx-comparable-medications__description\">\n\t\t\t\t\tThis medication is sold under brand names like Duac and BenzaClin, and combines the antiseptic properties of benzoyl peroxide with the antibiotic properties of clindamycin. This drug is used for inflammatory acne.\t\t\t\t<\/p>\n\t\t\t\t\t<\/div>\n\n\t\t\t<\/div>\n\n\n<div class=\"telyrx-product-list telyrx-product-list--single wp-block-telyrx-product-list\">\n\t\t\t\t\t<a class=\"telyrx-product-list__card telyrx-product-list__card--single\" href=\"https:\/\/telyrx.com\/medications\/adapalene-and-benzoyl-peroxide\">\n\t\t\t\t\t\t\t<img\n\t\t\t\t\tclass=\"telyrx-product-list__image\"\n\t\t\t\t\tsrc=\"https:\/\/telyrx.com\/media\/catalog\/product\/a\/d\/adapaleneandbenzoylperoxidegel-1019.jpg\"\n\t\t\t\t\talt=\"Adapalene and Benzoyl Peroxide\"\n\t\t\t\t\twidth=\"213\"\n\t\t\t\t\theight=\"213\"\n\t\t\t\t\tloading=\"lazy\"\n\t\t\t\t>\n\t\t\t\t\t\t<div class=\"telyrx-product-list__content\">\n\t\t\t\t<p class=\"telyrx-product-list__name\">Adapalene and Benzoyl Peroxide<\/p>\n\t\t\t\t<span class=\"telyrx-product-list__cta telyrx-product-list__cta--yellow\">\n\t\t\t\t\tView Product\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t<\/a>\n\t<\/div>\n\n\n<div class=\"telyrx-product-list-section alignfull wp-block-telyrx-product-list\">\n\t<h2 class=\"telyrx-product-list-section__heading\" data-toc-hidden=\"true\">We Have Adapalene and Benzoyl Peroxide in Stock. Get Yours Today!<\/h2>\n\t<div class=\"telyrx-product-list telyrx-product-list--footer-multi\">\n\t\t<div class=\"telyrx-product-list__grid\">\n\t\t\t\t\t\t\t<a class=\"telyrx-product-list__card\" href=\"https:\/\/telyrx.com\/medications\/adapalene-and-benzoyl-peroxide\">\n\t\t\t\t\t\t\t\t\t\t\t<img\n\t\t\t\t\t\t\tclass=\"telyrx-product-list__image\"\n\t\t\t\t\t\t\tsrc=\"https:\/\/telyrx.com\/media\/catalog\/product\/a\/d\/adapaleneandbenzoylperoxidegel-1019.jpg\"\n\t\t\t\t\t\t\talt=\"Adapalene and Benzoyl Peroxide\"\n\t\t\t\t\t\t\twidth=\"213\"\n\t\t\t\t\t\t\theight=\"213\"\n\t\t\t\t\t\t\tloading=\"lazy\"\n\t\t\t\t\t\t>\n\t\t\t\t\t\t\t\t\t\t<div class=\"telyrx-product-list__content\">\n\t\t\t\t\t\t<p class=\"telyrx-product-list__name\">Adapalene and Benzoyl Peroxide<\/p>\n\t\t\t\t\t\t<span class=\"telyrx-product-list__cta telyrx-product-list__cta--yellow\">\n\t\t\t\t\t\t\tOrder Now\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/a>\n\t\t\t\t\t<\/div>\n\t<\/div>\n\t\t\t<div class=\"telyrx-product-list-section__extra\">\n\t\t\t<p class=\"has-muted-color has-text-color has-urbanist-font-family\" style=\"font-size:0.875rem;font-style:italic;font-weight:400;line-height:1.571\"><strong>Important:<\/strong> Information on this page is for educational purposes only. Prescribing decisions are made by independent, licensed providers. TelyRx operates technology-enabled pharmacies and a telehealth platform that connects patients with board-certified licensed providers. Prescriptions, when provider-approved and issued, are filled and shipped by TelyRx-affiliated pharmacies. We do not employ physicians or make prescribing decisions. Learn more about our editorial standards <a href=\"\/blog\/editorial-standards\/\">here<\/a>.<\/p>\t\t<\/div>\n\t<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Adapalene and benzoyl peroxide is a prescription-strength topical gel medication primarily used to treat acne vulgaris. A multi-modal drug, it combines a retinoid (adapalene) and antiseptic agent (benzoyl peroxide) to target acne using different pathways. <\/p>\n<p>Adapalene and benzoyl peroxide is a highly potent topical that is gradually introduced to patients to minimize initial irritation. Side effects are common but typically mild, localized to the application site and resolving on its own as the skin acclimates to the new medication.<\/p>\n","protected":false},"author":2,"featured_media":7589,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"single-medication","format":"standard","meta":{"content-type":"","telyrx_subtitle":"Uses, Side Effects, Dosage & FAQs (2026 Guide)","telyrx_last_updated":"2026-04-03T17:36","telyrx_reviewer_name":"Nicholas Sesto","telyrx_reviewer_credentials":"PharmD","telyrx_reviewer_job_title":"Pharmacist","telyrx_reviewer_affiliation":"TelyRx","telyrx_reviewer_url":"","telyrx_show_reviewer_job_title":"0","telyrx_show_reviewer_affiliation":"0","telyrx_show_toc":"1","footnotes":"","_telyrx_clean_url":"\/medications\/adapalene-and-benzoyl-peroxide\/what-is\/"},"categories":[86],"tags":[],"class_list":["post-7588","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medications"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.2 (Yoast SEO v27.2) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>What Is Adapalene and Benzoyl Peroxide? 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