{"id":6390,"date":"2026-03-04T21:54:35","date_gmt":"2026-03-04T21:54:35","guid":{"rendered":"https:\/\/telyrx.com\/blog\/?p=6390"},"modified":"2026-03-25T21:48:04","modified_gmt":"2026-03-25T21:48:04","slug":"what-is-colchicine","status":"publish","type":"post","link":"https:\/\/telyrx.com\/blog\/medications\/what-is-colchicine\/","title":{"rendered":"What Is Colchicine?"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\" id=\"how-it-works\">How It Works<\/h2>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p>Colchicine works by reducing the body\u2019s inflammatory response to the uric acid crystals that cause gout. More specifically, it disrupts white blood cells (called neutrophils) that cause the joint inflammation and pain associated with gout and Familial Mediterranean fever.<\/p>\n\n\n\n<div class=\"quick-facts-card\">\n  <table class=\"quick-facts-table\">\n    <colgroup>\n      <col\/>\n      <col\/>\n    <\/colgroup>\n\n    <thead>\n      <tr>\n        <th colspan=\"2\">Quick Facts<\/th>\n      <\/tr>\n    <\/thead>\n\n    <tbody>\n      <tr>\n        <th>Common Brands<\/th>\n        <td>Colcrys, Gloperba, Lodoco, Mitigare<\/td>\n      <\/tr>\n\n      <tr>\n        <th>Drug Class<\/th>\n        <td>Alkaloid, Antigout agent<\/td>\n      <\/tr>\n\n      <tr>\n        <th>Generic Status<\/th>\n        <td>Generic for Colcrys<\/td>\n      <\/tr>\n\n      <tr>\n        <th>Availability<\/th>\n        <td>Prescription only<\/td>\n    <\/tbody>\n  <\/table>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"dosing\">Dosing<\/h2>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p>Colchicine is taken by mouth, with or without food. The dosage depends on what you\u2019re taking colchicine to treat.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Gout treatment:<\/strong> The recommended dose is 1.2 mg by mouth at the first sign of a flare, and 0.6 mg one hour later. It is often recommended to wait 3 days before repeating the dose regimen, even if you have another attack.<\/li>\n\n\n\n<li><strong>Gout prevention:<\/strong> The recommended dose is 0.6 mg taken by mouth once or twice daily.<\/li>\n\n\n\n<li><strong>Familial Mediterranean fever (FMF):<\/strong> The recommended dose for adults is between 1.2 mg to 2.4 mg by mouth once daily.<\/li>\n<\/ul>\n\n\n\n<div style=\"height:28px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><em><strong>Note:<\/strong>&nbsp;Dosing information is educational only. Your prescribing physician will&nbsp;determine&nbsp;your specific dose based on your individual health needs. Always follow your healthcare provider\u2019s instructions for exact dosing.<\/em><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"uses\">Uses<\/h2>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p><strong>FDA-Approved Uses<\/strong><\/p>\n\n\n\n<p>Colchicine is FDA-approved for:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Treating acute gout flares<\/li>\n\n\n\n<li>Preventing future gout attacks<\/li>\n\n\n\n<li>Treating familial Mediterranean fever (FMF)<\/li>\n<\/ul>\n\n\n\n<div style=\"height:28px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><strong>Off-Label Uses<\/strong><\/p>\n\n\n\n<p>You may see colchicine prescribed for uses that are not &#8220;FDA-approved.&#8221; This is a very common and legal practice called &#8220;off-label&#8221; prescribing, where a doctor uses their clinical judgment to prescribe a drug for a different (but well-researched) purpose.<\/p>\n\n\n\n<p>Colchicine may be prescribed off-label for coronary artery disease and recurrent pericarditis, an inflammation of the sac surrounding the heart.<\/p>\n\n\n<div class=\"telyrx-email-cta alignfull wp-block-telyrx-email-signup\">\n\t<h2 class=\"telyrx-email-cta__heading\" data-toc-hidden=\"true\">Get Savings Updates<\/h2>\n\t<p class=\"telyrx-email-cta__description\">Join our mailing list for exclusive deals and more.<\/p>\n\t\t\t<form\n\t\t\tid=\"telyrx-email-form-1\"\n\t\t\tclass=\"telyrx-email-cta__form\"\n\t\t\tdata-portal-id=\"46401311\"\n\t\t\tdata-form-id=\"14e1d7d5-6b17-4228-b42e-c06d1a6c240b\"\n\t\t\tdata-i18n=\"{&quot;subscribe&quot;:&quot;Subscribe&quot;,&quot;success&quot;:&quot;Thanks! You&#039;re subscribed.&quot;,&quot;error&quot;:&quot;Something went wrong. Please try again.&quot;}\"\n\t\t>\n\t\t\t<div class=\"telyrx-email-cta__pill\">\n\t\t\t\t<input\n\t\t\t\t\ttype=\"email\"\n\t\t\t\t\tname=\"email\"\n\t\t\t\t\tclass=\"telyrx-email-cta__input\"\n\t\t\t\t\tplaceholder=\"Enter your email\"\n\t\t\t\t\trequired\n\t\t\t\t\tautocomplete=\"email\"\n\t\t\t\t\/>\n\t\t\t\t<button type=\"submit\" class=\"telyrx-email-cta__button\">\n\t\t\t\t\tSubscribe\t\t\t\t<\/button>\n\t\t\t<\/div>\n\t\t\t<p class=\"telyrx-email-cta__status\" aria-live=\"polite\"><\/p>\n\t\t<\/form>\n\t\t<noscript>\n\t\t\t<p class=\"telyrx-email-cta__noscript\">Please enable JavaScript to use the signup form.<\/p>\n\t\t<\/noscript>\n\t<\/div>\n\n\n\n<section class=\"telyrx-side-effects\" data-toc-title=\"Side Effects\">\n\t<h2 class=\"telyrx-side-effects__heading\">Side Effects<\/h2>\n\t<hr class=\"telyrx-side-effects__separator\">\n\t<div class=\"telyrx-side-effects__content\">\n\t\t\n\n<p>Like all medications, colchicine can cause side effects. Some common side effects may improve over time as your body adjusts to the medication. Other side effects may be serious and require medical attention.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Common Side Effects<\/h3>\n\n\n\n<div class=\"telyrx-side-effects-chip telyrx-side-effects-chip--common\">\n\t\n\n<ul class=\"wp-block-list\">\n<li>Diarrhea<\/li>\n\n\n\n<li>Nausea<\/li>\n\n\n\n<li>Vomiting&nbsp;<\/li>\n\n\n\n<li>Stomach pain or cramping<\/li>\n\n\n\n<li>Sore throat<\/li>\n\n\n\n<li>Muscle problems<\/li>\n\n\n\n<li>Tiredness<\/li>\n\n\n\n<li>Headache<\/li>\n<\/ul>\n\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\">Serious Side Effects<\/h3>\n\n\n\n<div class=\"telyrx-side-effects-chip telyrx-side-effects-chip--serious\">\n\t\n\n<p>Serious side effects are rare, but it&#8217;s important to know what to look for if they do occur. Stop using colchicine and call your doctor immediately if you experience:&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Severe allergic reactions<\/strong>: Symptoms include swelling of the face, lips, tongue, or throat; difficulty breathing or swallowing; severe rash or itching; fever.&nbsp;<\/li>\n\n\n\n<li><strong>Muscle problems<\/strong>: Colchicine can cause muscle pain, weakness, or tenderness. In rare cases, this can lead to muscle breakdown (rhabdomyolysis), which can cause kidney damage. Symptoms include unexplained muscle weakness or cramps, low energy levels, dark-colored urine, and fever.<\/li>\n\n\n\n<li><strong>Blood disorders<\/strong>: Colchicine can affect the body&#8217;s ability to produce blood cells, leading to conditions like leukopenia (low white blood cells), pancytopenia (low blood cells) or thrombocytopenia (low platelets). Symptoms may include easy bruising or bleeding, frequent infection, unusual tiredness, headache, fever, abnormal or fast heartbeat, and pale skin or lips.<\/li>\n\n\n\n<li><strong>Nerve problems<\/strong>: Colchicine may cause nerve damage. Symptoms include pain, tingling, numbness, or burning sensations in the hands, arms, legs, or feet.<\/li>\n\n\n\n<li><strong>Fatal overdose: <\/strong>Taking too much colchicine has led to death. Seek emergency medical attention if you accidentally take more than your prescribed dose.<\/li>\n<\/ul>\n\n<\/div>\n\n\n\n<p class=\"has-muted-color has-text-color\" style=\"font-size:0.875rem\"><em>Call your doctor immediately if you experience any concerning or prolonged symptoms.<\/em><\/p>\n\n\t<\/div>\n<\/section>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"pharmacist-tips\">Pharmacist Tips<\/h2>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\">Avoid Grapefruit<\/h3>\n\n\n\n<p>Avoid eating grapefruit or drinking grapefruit juice while taking colchicine. Grapefruit interferes with how the body processes the medication, potentially leading to dangerously high levels of the drug in your system.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Measuring Liquid Doses<\/h3>\n\n\n\n<p>If prescribed the oral liquid (Gloperba), use the specific measuring device provided by your pharmacist. Household spoons are not accurate enough for this medication.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Store at Room Temperature<\/h3>\n\n\n\n<p>Store colchicine at room temperature, away from light and moisture.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Overdose<\/h3>\n\n\n\n<p>Even slight colchicine overdoses can be fatal. If you take too much colchicine, call 911 or Poison Control (1-800-222-1222).<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Missed Dose<\/h3>\n\n\n\n<p>If you miss a dose of colchicine, take it as soon as you remember. Do not double up on doses.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"drug-interactions\">Drug Interactions<\/h2>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p>Certain medications and substances can interact with colchicine, potentially altering how it works or increasing the risk of side effects. For example:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>CYP3A4 inhibitors &amp; P-gp inhibitors<\/strong>: Certain antibiotics (clarithromycin, erythromycin) and antifungals (ketoconazole, itraconazole) can significantly increase colchicine levels.<\/li>\n\n\n\n<li><strong>Cholesterol medications<\/strong>: Taking colchicine with statins (atorvastatin, simvastatin) or fibrates (gemfibrozil) increases the risk of muscle problems.<\/li>\n\n\n\n<li><strong>Heart and blood pressure medications<\/strong>: Interactions may occur when colchicine is combined with calcium channel blockers (diltiazem, verapamil) and digoxin.<\/li>\n\n\n\n<li><strong>HIV medications<\/strong>: Protease inhibitors like ritonavir or atazanavir can interact with colchicine.<\/li>\n<\/ul>\n\n\n\n<p>Always give your doctor and pharmacist a complete list of all your medications, vitamins, and supplements to check for potential interactions.<\/p>\n\n\n\n<section class=\"telyrx-faq-section\" data-toc-title=\"FAQs\">\n\t<h2 class=\"telyrx-faq-heading\">FAQs<\/h2>\n\t\t<div class=\"telyrx-faq-items\">\n\t\t\n\n<details class=\"telyrx-faq-item\">\n\t<summary class=\"telyrx-faq-question\">\n\t\t<span class=\"telyrx-faq-question-text\">Why is the standard dosage &#8220;two pills now, and one pill an hour later&#8221;?<\/span>\n\t\t<svg class=\"telyrx-faq-chevron\" width=\"20\" height=\"20\" viewBox=\"0 0 20 20\" fill=\"none\" aria-hidden=\"true\">\n\t\t\t<path d=\"M5 7.5L10 12.5L15 7.5\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n\t\t<\/svg>\n\t<\/summary>\n\t<div class=\"telyrx-faq-answer\">\n\t\t\n\n<p>This dosing regimen is designed to interrupt a gout attack while reducing the risk of overdosage. The recommended colchicine dosage for treating a gout flare-up is 1.2 mg (two tablets) at the first sign of an attack, followed by 0.6 mg (one tablet) one hour later.<\/p>\n\n\t<\/div>\n<\/details>\n\n\n\n<details class=\"telyrx-faq-item\">\n\t<summary class=\"telyrx-faq-question\">\n\t\t<span class=\"telyrx-faq-question-text\">Can I take colchicine with grapefruit or grapefruit juice?<\/span>\n\t\t<svg class=\"telyrx-faq-chevron\" width=\"20\" height=\"20\" viewBox=\"0 0 20 20\" fill=\"none\" aria-hidden=\"true\">\n\t\t\t<path d=\"M5 7.5L10 12.5L15 7.5\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n\t\t<\/svg>\n\t<\/summary>\n\t<div class=\"telyrx-faq-answer\">\n\t\t\n\n<p>No. It is recommended to avoid grapefruit and grapefruit juice while taking colchicine. Grapefruit slows the breakdown of colchicine in your body, which increases the risk of serious side effects.<\/p>\n\n\t<\/div>\n<\/details>\n\n\n\n<details class=\"telyrx-faq-item\">\n\t<summary class=\"telyrx-faq-question\">\n\t\t<span class=\"telyrx-faq-question-text\">Is colchicine a painkiller or an anti-inflammatory?<\/span>\n\t\t<svg class=\"telyrx-faq-chevron\" width=\"20\" height=\"20\" viewBox=\"0 0 20 20\" fill=\"none\" aria-hidden=\"true\">\n\t\t\t<path d=\"M5 7.5L10 12.5L15 7.5\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n\t\t<\/svg>\n\t<\/summary>\n\t<div class=\"telyrx-faq-answer\">\n\t\t\n\n<p>Colchicine is an anti-inflammatory medication, not a general painkiller. It specifically works to block the cells that cause joint inflammation in gout. It does not relieve other types of pain and should not be used as a general analgesic.<\/p>\n\n\t<\/div>\n<\/details>\n\n\n\n<details class=\"telyrx-faq-item\">\n\t<summary class=\"telyrx-faq-question\">\n\t\t<span class=\"telyrx-faq-question-text\">Why is colchicine used for heart inflammation?<\/span>\n\t\t<svg class=\"telyrx-faq-chevron\" width=\"20\" height=\"20\" viewBox=\"0 0 20 20\" fill=\"none\" aria-hidden=\"true\">\n\t\t\t<path d=\"M5 7.5L10 12.5L15 7.5\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n\t\t<\/svg>\n\t<\/summary>\n\t<div class=\"telyrx-faq-answer\">\n\t\t\n\n<p>Although primarily an anti-gout agent, colchicine modulates the body&#8217;s inflammatory pathways. Neutrophils, which cause joint inflammation in gout, are also involved in the inflammation associated with coronary artery disease and pericarditis. Colchicine may be prescribed for this purpose.<\/p>\n\n\t<\/div>\n<\/details>\n\n\n\n<details class=\"telyrx-faq-item\">\n\t<summary class=\"telyrx-faq-question\">\n\t\t<span class=\"telyrx-faq-question-text\">Can I take colchicine every day for gout prevention?<\/span>\n\t\t<svg class=\"telyrx-faq-chevron\" width=\"20\" height=\"20\" viewBox=\"0 0 20 20\" fill=\"none\" aria-hidden=\"true\">\n\t\t\t<path d=\"M5 7.5L10 12.5L15 7.5\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n\t\t<\/svg>\n\t<\/summary>\n\t<div class=\"telyrx-faq-answer\">\n\t\t\n\n<p>Yes, for the prevention of gout flares, colchicine can be taken daily. The recommended dose for gout prevention is 0.6 mg by mouth once or twice daily. Dosing for treating an active flare is different and should not be done daily.<\/p>\n\n\t<\/div>\n<\/details>\n\n\n\n<details class=\"telyrx-faq-item\">\n\t<summary class=\"telyrx-faq-question\">\n\t\t<span class=\"telyrx-faq-question-text\">Can I take ibuprofen or naproxen at the same time as colchicine?<\/span>\n\t\t<svg class=\"telyrx-faq-chevron\" width=\"20\" height=\"20\" viewBox=\"0 0 20 20\" fill=\"none\" aria-hidden=\"true\">\n\t\t\t<path d=\"M5 7.5L10 12.5L15 7.5\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n\t\t<\/svg>\n\t<\/summary>\n\t<div class=\"telyrx-faq-answer\">\n\t\t\n\n<p>NSAIDs like ibuprofen or naproxen are not known to negatively interact with colchicine. However, because taking multiple medications can increase risks, it\u2019s best to your healthcare provider to ensure this combination is safe for you.<\/p>\n\n\t<\/div>\n<\/details>\n\n\n\n<details class=\"telyrx-faq-item\">\n\t<summary class=\"telyrx-faq-question\">\n\t\t<span class=\"telyrx-faq-question-text\">How long does it take for colchicine to stop a gout flare?<\/span>\n\t\t<svg class=\"telyrx-faq-chevron\" width=\"20\" height=\"20\" viewBox=\"0 0 20 20\" fill=\"none\" aria-hidden=\"true\">\n\t\t\t<path d=\"M5 7.5L10 12.5L15 7.5\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n\t\t<\/svg>\n\t<\/summary>\n\t<div class=\"telyrx-faq-answer\">\n\t\t\n\n<p>Colchicine tablets are designed to work quickly to treat gout flares if taken immediately. It is recommended to take the first dose at the first sign of pain.<\/p>\n\n\t<\/div>\n<\/details>\n\n\n\n<details class=\"telyrx-faq-item\">\n\t<summary class=\"telyrx-faq-question\">\n\t\t<span class=\"telyrx-faq-question-text\">Is colchicine safe to take during pregnancy?<\/span>\n\t\t<svg class=\"telyrx-faq-chevron\" width=\"20\" height=\"20\" viewBox=\"0 0 20 20\" fill=\"none\" aria-hidden=\"true\">\n\t\t\t<path d=\"M5 7.5L10 12.5L15 7.5\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n\t\t<\/svg>\n\t<\/summary>\n\t<div class=\"telyrx-faq-answer\">\n\t\t\n\n<p>It is currently not known if or how colchicine affects pregnancy or if it can harm an unborn baby. If you are pregnant or planning to become pregnant, talk with your healthcare provider about whether colchicine is safe for you.<\/p>\n\n\t<\/div>\n<\/details>\n\n\n\n<details class=\"telyrx-faq-item\">\n\t<summary class=\"telyrx-faq-question\">\n\t\t<span class=\"telyrx-faq-question-text\">Can I drink alcohol while taking colchicine?<\/span>\n\t\t<svg class=\"telyrx-faq-chevron\" width=\"20\" height=\"20\" viewBox=\"0 0 20 20\" fill=\"none\" aria-hidden=\"true\">\n\t\t\t<path d=\"M5 7.5L10 12.5L15 7.5\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n\t\t<\/svg>\n\t<\/summary>\n\t<div class=\"telyrx-faq-answer\">\n\t\t\n\n<p>It is unknown if alcohol directly interacts with colchicine, but alcohol is known to increase the risk of gout attacks. Talk to your healthcare provider about whether you should avoid alcohol while taking colchicine.<\/p>\n\n\t<\/div>\n<\/details>\n\n\n\n<details class=\"telyrx-faq-item\">\n\t<summary class=\"telyrx-faq-question\">\n\t\t<span class=\"telyrx-faq-question-text\">Does colchicine affect male or female fertility?<\/span>\n\t\t<svg class=\"telyrx-faq-chevron\" width=\"20\" height=\"20\" viewBox=\"0 0 20 20\" fill=\"none\" aria-hidden=\"true\">\n\t\t\t<path d=\"M5 7.5L10 12.5L15 7.5\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n\t\t<\/svg>\n\t<\/summary>\n\t<div class=\"telyrx-faq-answer\">\n\t\t\n\n<p>Rarely, colchicine can cause infertility in men, which may make it difficult to get a female partner pregnant. This effect may be reversible once the medication is stopped.<\/p>\n\n\t<\/div>\n<\/details>\n\n\t<\/div>\n<\/section>\n<script type=\"application\/ld+json\">{\"@context\":\"https:\/\/schema.org\",\"@type\":\"FAQPage\",\"mainEntity\":[{\"@type\":\"Question\",\"name\":\"Why is the standard dosage \\\"two pills now, and one pill an hour later\\\"?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"This dosing regimen is designed to interrupt a gout attack while reducing the risk of overdosage. The recommended colchicine dosage for treating a gout flare-up is 1.2 mg (two tablets) at the first sign of an attack, followed by 0.6 mg (one tablet) one hour later.\"}},{\"@type\":\"Question\",\"name\":\"Can I take colchicine with grapefruit or grapefruit juice?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"No. It is recommended to avoid grapefruit and grapefruit juice while taking colchicine. 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If you are pregnant or planning to become pregnant, talk with your healthcare provider about whether colchicine is safe for you.\"}},{\"@type\":\"Question\",\"name\":\"Can I drink alcohol while taking colchicine?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"It is unknown if alcohol directly interacts with colchicine, but alcohol is known to increase the risk of gout attacks. Talk to your healthcare provider about whether you should avoid alcohol while taking colchicine.\"}},{\"@type\":\"Question\",\"name\":\"Does colchicine affect male or female fertility?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Rarely, colchicine can cause infertility in men, which may make it difficult to get a female partner pregnant. This effect may be reversible once the medication is stopped.\"}}]}<\/script>\n\n<div class=\"telyrx-comparable-medications wp-block-telyrx-comparable-medications\">\n\t<h2 class=\"telyrx-comparable-medications__title\">Comparable Medications<\/h2>\n\t\t\t<div class=\"telyrx-comparable-medications__intro\">\n\n<p><strong>Colchicine, Colcrys, Mitigare, Indomethacin (Indocin), Prednisone, Naproxen, or Allopurinol (Zyloprim)?<\/strong><\/p>\n\n\n\n<p>There are several medications that your doctor can prescribe in place of colchicine. Here are a few possible alternatives below.<\/p>\n\n<\/div>\n\t\t\t\t<div class=\"telyrx-comparable-medications__item\">\n\t\t\t<div class=\"telyrx-comparable-medications__item-top\">\n\t\t\t\t<div class=\"telyrx-comparable-medications__item-info\">\n\t\t\t\t\t<h3 class=\"telyrx-comparable-medications__name\">\n\t\t\t\t\t\t\t\t\t\t\t\t\tColcrys\t\t\t\t\t\t\t\t\t\t\t<\/h3>\n\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<p class=\"telyrx-comparable-medications__description\">\n\t\t\t\t\tBrand-name colchicine tablets used to both treat and prevent gout flares and treat FMF.\t\t\t\t<\/p>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<hr class=\"telyrx-comparable-medications__divider\">\n\t\t\t\t\t<div class=\"telyrx-comparable-medications__item\">\n\t\t\t<div class=\"telyrx-comparable-medications__item-top\">\n\t\t\t\t<div class=\"telyrx-comparable-medications__item-info\">\n\t\t\t\t\t<h3 class=\"telyrx-comparable-medications__name\">\n\t\t\t\t\t\t\t\t\t\t\t\t\tMitigare\t\t\t\t\t\t\t\t\t\t\t<\/h3>\n\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<p class=\"telyrx-comparable-medications__description\">\n\t\t\t\t\tBrand-name colchicine capsules used only to prevent gout flares.\t\t\t\t<\/p>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<hr class=\"telyrx-comparable-medications__divider\">\n\t\t\t\t\t<div class=\"telyrx-comparable-medications__item\">\n\t\t\t<div class=\"telyrx-comparable-medications__item-top\">\n\t\t\t\t<div class=\"telyrx-comparable-medications__item-info\">\n\t\t\t\t\t<h3 class=\"telyrx-comparable-medications__name\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"telyrx-comparable-medications__name-link\" href=\"https:\/\/telyrx.com\/medications\/indomethacin-er\">\n\t\t\t\t\t\t\t\tIndomethacin ER Capsules\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/h3>\n\n\t\t\t\t\t\t\t\t\t\t\t<p class=\"telyrx-comparable-medications__price\">\n\t\t\t\t\t\t\tFrom $37.99\t\t\t\t\t\t<\/p>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<a class=\"telyrx-comparable-medications__cta\" href=\"https:\/\/telyrx.com\/medications\/indomethacin-er\">\n\t\t\t\t\t\tView Product\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<p class=\"telyrx-comparable-medications__description\">\n\t\t\t\t\tA non-steroidal anti-inflammatory drug (NSAID) used to treat pain, arthritis, gout, ankylosing spondylitis, bursitis, and a congenital heart defect called patent ductus arteriosus.\t\t\t\t<\/p>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<hr class=\"telyrx-comparable-medications__divider\">\n\t\t\t\t\t<div class=\"telyrx-comparable-medications__item\">\n\t\t\t<div class=\"telyrx-comparable-medications__item-top\">\n\t\t\t\t<div class=\"telyrx-comparable-medications__item-info\">\n\t\t\t\t\t<h3 class=\"telyrx-comparable-medications__name\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"telyrx-comparable-medications__name-link\" href=\"https:\/\/telyrx.com\/medications\/prednisone-tablets\">\n\t\t\t\t\t\t\t\tPrednisone Tablets\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/h3>\n\n\t\t\t\t\t\t\t\t\t\t\t<p class=\"telyrx-comparable-medications__price\">\n\t\t\t\t\t\t\tFrom $35.99\t\t\t\t\t\t<\/p>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<a class=\"telyrx-comparable-medications__cta\" href=\"https:\/\/telyrx.com\/medications\/prednisone-tablets\">\n\t\t\t\t\t\tView Product\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<p class=\"telyrx-comparable-medications__description\">\n\t\t\t\t\tA corticosteroid used to treat pain and inflammation caused by various conditions, including arthritis, severe allergies, asthma, multiple sclerosis, lupus, and skin disorders.\t\t\t\t<\/p>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<hr class=\"telyrx-comparable-medications__divider\">\n\t\t\t\t\t<div class=\"telyrx-comparable-medications__item\">\n\t\t\t<div class=\"telyrx-comparable-medications__item-top\">\n\t\t\t\t<div class=\"telyrx-comparable-medications__item-info\">\n\t\t\t\t\t<h3 class=\"telyrx-comparable-medications__name\">\n\t\t\t\t\t\t\t\t\t\t\t\t\tNaproxen\t\t\t\t\t\t\t\t\t\t\t<\/h3>\n\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<p class=\"telyrx-comparable-medications__description\">\n\t\t\t\t\tAn over-the-counter and prescription NSAID used to treat gout attacks, ankylosing spondylitis, bursitis, osteoarthritis, tendonitis, rheumatoid arthritis, and painful menstrual cramps (dysmenorrhea).\t\t\t\t<\/p>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<hr class=\"telyrx-comparable-medications__divider\">\n\t\t\t\t\t<div class=\"telyrx-comparable-medications__item\">\n\t\t\t<div class=\"telyrx-comparable-medications__item-top\">\n\t\t\t\t<div class=\"telyrx-comparable-medications__item-info\">\n\t\t\t\t\t<h3 class=\"telyrx-comparable-medications__name\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"telyrx-comparable-medications__name-link\" href=\"https:\/\/telyrx.com\/medications\/allopurinol\">\n\t\t\t\t\t\t\t\tAllopurinol\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<\/h3>\n\n\t\t\t\t\t\t\t\t\t\t\t<p class=\"telyrx-comparable-medications__price\">\n\t\t\t\t\t\t\tFrom $24.99\t\t\t\t\t\t<\/p>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<a class=\"telyrx-comparable-medications__cta\" href=\"https:\/\/telyrx.com\/medications\/allopurinol\">\n\t\t\t\t\t\tView Product\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<p class=\"telyrx-comparable-medications__description\">\n\t\t\t\t\tA xanthine oxidase inhibitor used to treat high uric acid levels caused by gout, cancer medications, and kidney stones.\t\t\t\t<\/p>\n\t\t\t\t\t<\/div>\n\n\t\t\t<\/div>\n\n\n<div class=\"telyrx-product-list telyrx-product-list--single wp-block-telyrx-product-list\">\n\t\t\t\t\t<a class=\"telyrx-product-list__card telyrx-product-list__card--single\" href=\"https:\/\/telyrx.com\/medications\/colchicine\">\n\t\t\t\t\t\t\t<img\n\t\t\t\t\tclass=\"telyrx-product-list__image\"\n\t\t\t\t\tsrc=\"https:\/\/telyrx.com\/media\/catalog\/product\/c\/o\/colchicine_.6mg-155_1.png\"\n\t\t\t\t\talt=\"Colchicine\"\n\t\t\t\t\twidth=\"213\"\n\t\t\t\t\theight=\"213\"\n\t\t\t\t\tloading=\"lazy\"\n\t\t\t\t>\n\t\t\t\t\t\t<div class=\"telyrx-product-list__content\">\n\t\t\t\t<p class=\"telyrx-product-list__name\">Colchicine<\/p>\n\t\t\t\t<span class=\"telyrx-product-list__cta telyrx-product-list__cta--yellow\">\n\t\t\t\t\tView Product\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t<\/a>\n\t<\/div>\n\n\n<div class=\"telyrx-product-list-section alignfull wp-block-telyrx-product-list\">\n\t<h2 class=\"telyrx-product-list-section__heading\">We Have Colchicine in Stock. Get Yours Today!<\/h2>\n\t<div class=\"telyrx-product-list telyrx-product-list--footer-multi\">\n\t\t<div class=\"telyrx-product-list__grid\">\n\t\t\t\t\t\t\t<a class=\"telyrx-product-list__card\" href=\"https:\/\/telyrx.com\/medications\/colchicine\">\n\t\t\t\t\t\t\t\t\t\t\t<img\n\t\t\t\t\t\t\tclass=\"telyrx-product-list__image\"\n\t\t\t\t\t\t\tsrc=\"https:\/\/telyrx.com\/media\/catalog\/product\/c\/o\/colchicine_.6mg-155_1.png\"\n\t\t\t\t\t\t\talt=\"Colchicine\"\n\t\t\t\t\t\t\twidth=\"213\"\n\t\t\t\t\t\t\theight=\"213\"\n\t\t\t\t\t\t\tloading=\"lazy\"\n\t\t\t\t\t\t>\n\t\t\t\t\t\t\t\t\t\t<div class=\"telyrx-product-list__content\">\n\t\t\t\t\t\t<p class=\"telyrx-product-list__name\">Colchicine<\/p>\n\t\t\t\t\t\t<span class=\"telyrx-product-list__cta telyrx-product-list__cta--yellow\">\n\t\t\t\t\t\t\tOrder Now\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/a>\n\t\t\t\t\t<\/div>\n\t<\/div>\n\t\t\t<div class=\"telyrx-product-list-section__extra\">\n\t\t\t<p class=\"has-muted-color has-text-color has-urbanist-font-family\" style=\"font-size:0.875rem;font-style:italic;font-weight:400;line-height:1.571\"><strong>Important:<\/strong> Information on this page is for educational purposes only. Prescribing decisions are made by independent, licensed providers. TelyRx operates technology-enabled pharmacies and a telehealth platform that connects patients with board-certified licensed providers. Prescriptions, when provider-approved and issued, are filled and shipped by TelyRx-affiliated pharmacies. We do not employ physicians or make prescribing decisions. Learn more about our editorial standards <a href=\"\/blog\/editorial-standards\/\">here<\/a>.<\/p>\t\t<\/div>\n\t<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Colchicine is a prescription medication used to treat and prevent acute gout attacks. Gout is a specific form of inflammatory arthritis caused by the accumulation of uric acid crystals within the joints. This buildup can lead to sudden and severe pain, swelling, and inflammation in joints, oftentimes in the big toe, ankle, or knee.\u00a0Colchicine is also used to treat Familial Mediterranean fever (FMF), a rare genetic condition characterized with recurrent fever and inflammation.<\/p>\n<p><a href=\"https:\/\/telyrx.com\/medications\/colchicine\">Colchicine<\/a> is available in multiple forms, including oral tablets, capsules, and a liquid solution. Common side effects include diarrhea, nausea, vomiting, and stomach pain.<\/p>\n","protected":false},"author":2,"featured_media":6367,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"single-medication","format":"standard","meta":{"content-type":"","telyrx_subtitle":"Uses, Side Effects, Dosage, and FAQs (2026 Guide)","telyrx_last_updated":"2026-03-20T10:30","telyrx_reviewer_name":"Ashley Robinson, PharmD, TelyRx Pharmacy Manager","telyrx_reviewer_credentials":"","telyrx_reviewer_job_title":"","telyrx_reviewer_affiliation":"","telyrx_reviewer_url":"","telyrx_show_reviewer_job_title":"","telyrx_show_reviewer_affiliation":"","telyrx_show_toc":"1","footnotes":"","_telyrx_clean_url":"\/medications\/colchicine\/what-is\/"},"categories":[86],"tags":[],"class_list":["post-6390","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medications"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.2 (Yoast SEO v27.2) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>What Is Colchicine? Uses, Dosage, and FAQs (2026 Guide)<\/title>\n<meta name=\"description\" content=\"Learn what colchicine is, how it works, common side effects, and how to get it prescribed and delivered online through TelyRx.com.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/telyrx.com\/blog\/medications\/what-is-colchicine\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"What Is Colchicine?\" \/>\n<meta property=\"og:description\" content=\"Learn what colchicine is, how it works, common side effects, and how to get it prescribed and delivered online through TelyRx.com.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/telyrx.com\/blog\/medications\/what-is-colchicine\/\" \/>\n<meta property=\"og:site_name\" content=\"TelyRx Blog\" \/>\n<meta property=\"article:published_time\" content=\"2026-03-04T21:54:35+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-03-25T21:48:04+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/telyrx.com\/blog\/wp-content\/uploads\/2026\/03\/Meloxicam.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"900\" \/>\n\t<meta property=\"og:image:height\" content=\"900\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Mariah Powers\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Mariah Powers\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"8 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/telyrx.com\/blog\/medications\/what-is-colchicine\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/telyrx.com\/blog\/medications\/what-is-colchicine\/\"},\"author\":{\"name\":\"Mariah Powers\",\"@id\":\"https:\/\/telyrx.com\/blog\/#\/schema\/person\/f1042a29c24ab7dd3c5f0fff9a06746b\"},\"headline\":\"What Is Colchicine?\",\"datePublished\":\"2026-03-04T21:54:35+00:00\",\"dateModified\":\"2026-03-20T10:30:00+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/telyrx.com\/blog\/medications\/what-is-colchicine\/\"},\"wordCount\":1209,\"publisher\":{\"@id\":\"https:\/\/telyrx.com\/blog\/#organization\"},\"image\":{\"@id\":\"https:\/\/telyrx.com\/blog\/medications\/what-is-colchicine\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/telyrx.com\/blog\/wp-content\/uploads\/2026\/03\/Meloxicam.jpeg\",\"articleSection\":[\"Medications\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/telyrx.com\/blog\/medications\/what-is-colchicine\/\",\"url\":\"https:\/\/telyrx.com\/blog\/medications\/what-is-colchicine\/\",\"name\":\"What Is Colchicine? 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